Ana Angulo-Urarte

Our review "When, where and which PIK3CA mutations are pathogenic in congenital disorders" in @NatureCVR is out! Hope u enjoy and learn as much as @MarionaGraupera and I have done writting it. 🔗rdcu.be/cTg1j #PROS #PI3K

🤔How do you design a promoter for stable titration of expression? 💡Try programmable promoter editing with DIAL! 📰Now published at @NatureBiotech 🧵 [1/n] 🔗 below

Join us for our next Western 🌙 Session: 📅 22 Jan ⏰ 17:30 GMT With: Chen Yuan Kam 🐭 Investigating vascular dynamics via 4D imaging of living mouse skin Camilla Autorino 🐟 A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics

No me canso de ver este vídeo.

Structural variants in the 3D genome as drivers of disease. #StructuralVariants #3Dgenome #Genomics @NatureRevGenet nature.com/articles/s4157…

🌟 New hope for #PHTS patients! 🔬 @MarionaGraupera and Sandra Castillo finds at @CD_AACR that common anticancer drugs targeting PI3K downstream effectors reduce vascular malformations & pain in a novel PHTS mouse model Read the full story! 🔗 carrerasresearch.org/en/news/common…

A special day at the @BecarisFLC Awards Ceremony. Proud to be part of this amazing community. Excited for what’s ahead! #LaCaixaJuniorLeaderFellow

Tremenda esta carta

We are looking for a postdoc for an ERC funded project at @AlbertPol10 Lab at @idibaps in Barcelona. Do you want to use 3D #epithelioids to study the role of lipid droplets against bacterial infections? Com and join us! clinicbarcelona.org/uploads/media/…

Happy to share Zeenat's paper in Angiogenesis on differences between arterial and venous cell sizes and the specific role of endoglin signaling in veins! Great job! link.springer.com/10.1007/s10456…

🔬👏 Enhorabuena a la investigadora #caixaresearch @MarionaGraupera (@CarrerasIJC). Con una @ERC_Research Synergy Grant estudiará el comportamiento de las células endoteliales para profundizar en las enfermedades relacionadas con los vasos sanguíneos. 👇 lavanguardia.com/ciencia/202412…

'A panoramic view of cell population dynamics in mammalian aging' science.org/doi/10.1126/sc…

Looking forward to it !! :)

We know that Christmas can be an expensive time of year. At GoPI3Ks we are offering small monetary grants to help make your festive season easier. If you live with PROS or a family affected by PROS, please fill out our application form: docs.google.com/forms/d/e/1FAI… Deadline is: 7 Dec

A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells. @teichlab @NosedaMichela #CellAtlas #Organotypic #Angiogenesis nature.com/articles/s4159…

We are thrilled to share that our first paper from my new lab, Spateo (github.com/aristoteleo/sp…) for spatiotemporal modeling of molecular holograms, is now online in Cell: cell.com/cell/fulltext/…. Spateo is a comprehensive analytical framework for 3D whole-embryo spatiotemporal modeling. Its advanced features include: • 3D alignment and reconstruction at the whole-mouse-embryo scale (see the animation). • 3D spatial domain digitization and cell-cell communication analysis to understand spatial gene expression gradients and both inter- and intracellular communication. • 3D morphometric and volumetric analyses along with 3D morphogenesis vector field modeling to quantify dynamics such as surface area, volume, and cell density across organs, and to dissect the interplay between morphogenesis factors and cell migration. • A “Google Earth”-like browser, Spateo-viewer (viewer.spateo.aristoteleo.com and github.com/aristoteleo/sp…), for interactive and intuitive exploration of 3D spatial data. • Additional features, such as RNA signal-based single-cell segmentation. We are also honored that Nature “News and Views” has highlighted this work as well: nature.com/articles/d4158…. This is really an amazing outcome after two years' heroic revision process that rewrite the entire paper using a new data (doi.org/10.1101/2024.0…) for whole mouse embryos.

Cell–cell junctions in focus – imaging junctional architectures and dynamics at high resolution journals.biologists.com/jcs/article/13… What did advanced microscopists do to our point of view? #superresolution #volumeEM #optogenetics #biosensors with @vera_janssen1

Calling junior/early career scientists! 🧪 My lab is hiring a Research Assistant! If you're motivated to learn about metabolism and peroxisomes and ready to dive into exciting projects, contact us: jobrxiv.org/job/universida… #AcademicJob #PhDlife @CIBM_UGR @CanalUGR

@KarinaYaniv @MarionaGraupera @valentatormenta 🙌🙌🙌🙌🙌

This is us 3 hours, and 15 minutes before the interview in Brussels 😃. We are so grateful and honored to receive this huge recognition! But the friendship, the team work, the support, the experiences we accumulated together, are the real prize! @MarionaGraupera @valentatormenta

@Bertava4 @NatImmunol @vaquerolab Congrats 🎉

Here it is! Our paper on how protein deacetylase SIRT7 promotes B cell development is out today in @NatImmunol. Such a honor to contribute to this work with @vaquerolab and amazing PhD student Andrés Gámez. Many thanks to all collaborators!! nature.com/articles/s4159…

@BernaSozen_ @Nature Love It!

Our latest out today @Nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…