Anna Tocheva

Great effort from the team on this study published in Cell today! Hard work pays off - well done everyone 👏🏻 Exciting science - discovering new T-cell receptors for cancer immunotherapies 🔬 #cancerimmunotherpies #cellscience #tcells cell.com/cell/fulltext/…

Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature nature.com/articles/s4158…

NEW PUBLICATION from our lab @CellReports! In this work we sought to elucidate function by charting dynamic spatiotemporal & genetic regulation of #RNAediting across human brain development. @SeaverAutism @SinaiBrain @SinaiGenetics @MountSinaiPsych cell.com/cell-reports/f…

Result of a great collaboration between our group, @MiriamMerad, many others at Sinai and also Regeneron. The data is really beautiful and provides more understanding about the re-priming conditions for effective PD1 therapy.

My #Tweetorial on our recent work on the roles of T cell intrinsic #androgen receptor (AR) in CD8+ T cell exhaustion in cancer. 1/n Link to the original paper: science.org/doi/10.1126/sc… Press release for the public: sciencedaily.com/releases/2022/…

Please help us spread the word: phenomenal organizers and amazing speakers for the 2022 #globalimmuno talks👇 #Immunity @ImmunologyAAI @CytokineSociety @ASImmunology @FAISAfrica @EFIS_Immunology @iuis_online @SocLatAlergia

Online now: Are NKT cells a useful predictor of COVID-19 severity? dlvr.it/SHM0QK

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on March 4. Talks will feature recent exciting computational and experimental advances and will be livestreamed at satijalab.org/scgd. Please RT/spread the word!

@JustinPerryPhD @MaxKrummel @InspectingI @JustinPerryPhD Yes, it's a pre-print up on BioRxiv! biorxiv.org/content/10.110…

Exhausted T cells and Tumor macrophages are symbiotic. @KellyKersten8 shows TAM induce a unique synapse, priming Tex for exhaustion w/o inducing proliferation. Meanwhile Tex attract and promote TAMs. ZipSeq shows this is spatially localized in tumors. https://tinyurl/TAMTex

BREAKING NEWS: The 2021 #NobelPrize in Physiology or Medicine has been awarded jointly to David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch.”

Using an allele-conditioning strategy, @lawrenceandrews generate mice that temporally restrict Cre activity and gene deletion to CD4+ T conventional cells, while sparing CD4+ T regulatory cells. @Vignali_Lab cell.com/immunity/fullt…

We are so excited to finally share our new study reporting the evolution of cross-resistance between targeted therapy and immunotherapy, published today @NatureCancer. Highlights in the 🧵👇 Free access here rdcu.be/coKr9 1/25