Tyson

476 posts

Tyson

Tyson

@buildandhold

Phoenix, AZ Katılım Mayıs 2009
1.3K Takip Edilen355 Takipçiler
Nat Eliason
Nat Eliason@nateliason·
Very disappointed by this from @WHOOP I bought a bundle of four lab tests last year… and apparently my purchase expires? There’s zero reason to take away tests I already paid for.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
What peptide should I test next?
Bryan Johnson@bryan_johnson

People mistakenly believe peptides are only good. Peptides can be bad, too. They can cause adverse effects. Some dangerous. I did a peptide experiment and measured its effects in my body. The results are complicated. I tried a peptide called CJC-1295. It pushed my growth hormone up by ~8x. That’s good. That’s what it was supposed to do. But, it also came with adverse effects: > increased my morning fasted blood sugar up 20% > increased stress hormone by 12% > tanked my REM sleep by 23% > made my pancreas work 53% harder and was still losing to rising blood glucose > increased my insulin resistance by 50% These were the most obvious side effects, and I only ran a very narrow panel for this experiment. So I’m sure there’s more. I stopped after two doses, without even reaching the intended target dose. For those of you new to peptides, your body sends instructions to itself using tiny chemical messengers called peptides. There are thousands of them. For example, GLP-1s are drugs that take an existing class of short-lived peptides and modify them to extend their activity duration, which turns them into drugs, following rigorous clinical testing. CJC-1295 is one of those peptide-drugs. It tells your brain to release more growth hormone. Growth hormone is your body's signal to build muscle, repair tissue, and recover. However, and like most grey market peptides, CJC-1295 did not succeed its clinical trial, and hence never became an “official” drug. There is a version called CJC-1295 with DAC. DAC is an attachment glued onto the peptide that makes it last for days in your body instead of hours. One shot, longer effect, just like GLP-1s. Why people use it: more growth hormone could mean better recovery, leaner body, faster healing. The experiment I completed. Two injections a week of CJC-1295 with DAC: > 1.2 mg > 1.8 mg 48 hours after the first injection I was nearly comatose. It felt like severe jet lag, the type you’d feel after traveling nine time zones. My sleep was wrecked and I felt continuously awful. My REM sleep dropped by 23%. REM is when your brain processes memories and repairs itself. Less time for my brain to repair itself. During the experiment, I never felt rested and always fatigued. Why we chose CJC-1295 with DAC. Some will say we picked the wrong peptide. They will say I should have used a different version, CJC-1295 without DAC, mixed with another peptide called Ipamorelin. We went with CJC-1295 with DAC instead as it has the most controlled studies. CJC-1295 with DAC has 2 controlled trials in healthy adults. Ipamorelin alone has 1 controlled trial in healthy adults, plus 1 study that failed when they tried it on bowel surgery patients. The mix of the two has zero controlled trials. On Ipamorelin, it copies a chemical called ghrelin, the one that makes you hungry. On its own it gives you a quick burst of growth hormone that fades fast. It does not keep your longer acting growth signal (called IGF-1) up. Clinics mix Ipamorelin with CJC-1295 no-DAC because the two together are supposed to work better. But we don’t know if that’s accurate because we don’t have trial data. This is a problem with peptides. Almost none of them have been tested properly. We are flying blind. Most of what people use is based on what someone said online, what a clinic claims, or what a friend reports from their subjective feelings. Peptides have the potential to be great when well-studied.

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Bernz
Bernz@BigBernard1990·
@_9th_Life_ Yup now if I could only find a solid reta source I’d be cooking but already two failed attempts from two different site. Prob just stick to what I can get from compound pharmacy for now
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9th Life
9th Life@_9th_Life_·
I have a close of my friend that had his total testosterone shoot up from 767 to 1332 ng/dl on Enclomiphene mono therapy Has anyone else seen results like this? Probably the craziest hyper responder case study I have ever seen personally
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Tyson
Tyson@buildandhold·
@levelsio Required by your local municipality…
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@levelsio
@levelsio@levelsio·
Yep we're essentially all gassing ourselves with CO2 especially with the new energy saving insulation that makes houses air tight boxes, very bad for our brains!
Johannes Schmidt@spaceMonster

@levelsio Western civilisation is sleeping on this problem since it only was created 20-40 years ago. Before that windows where not that airtight. Also cheap CO2 sensors ate only available for 10 years before that they where prohibitly expensive.

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Tyson
Tyson@buildandhold·
@hey_mindi Yes PE has turned the veterinary practice into an absolute racket.
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Mindi
Mindi@hey_mindi·
There is something catastrophically wrong with Americas vet business. I sat for 3 hours yesterday with our 11 year old dog. Test after test. I kept signing financial agreement papers, desperate to find an answer to what’s wrong. Every step of the way, a thorough explanation of the need to do xyz. Always with the sentence at the end “that runs $____” Sign this. By the end of the 3 hours, my choices were pay $5000 to admit her for the rest of the afternoon or put her down. I couldn’t think straight. I walked in with her hours prior thinking she just had some little bug that would be simple to resolve. I can’t stop thinking about how many people would have to choose option 2, because $5000 out of left field isn’t possible to pay. I also can’t believe that I was forced to sit and watch a 14 min vaccine commercial reel on repeat for 3 hours while I contemplated our devastating circumstances. This can’t be the norm. If you have a prayer, I humbly ask if you’d lift our family up this Easter Sunday.
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Ryan Dreyer 🪓
Ryan Dreyer 🪓@theryandreyer·
Finally had enough of Big Light $25 bucks on Amazon and a return to soul
Ryan Dreyer 🪓 tweet mediaRyan Dreyer 🪓 tweet media
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Welf
Welf@_welf·
today I'm launching @supermirror_app the #1 performant Mac-to-Android mirroring app 60 fps, <10ms, lossless, optimized for E-Ink devices which means: you can now use your mac, on paper for calm computing, deeper focus and better sleep first prototype built with Opus 4.6 in a few hours, relentlessly optimized since - beautiful menu bar app - clamshell mode, touch input - keyboard shortcuts, full CLI (hi claude) - any android 8 device or newer - 5 min setup it's been such a joy to build this simple product to autistic levels of quality and performance free 7 day trial, then $29 forever really hope you enjoy it link below
Welf tweet mediaWelf tweet media
Welf@_welf

Opus 4.6 is insane. Today we vibecoded what might be the best vibecoding setup in the world: a mirroring solution to use the @daylightco DC-1 as external display for my Mac. Anything you do on a Mac — now on a paperlike screen, no blue light, no PWM flicker → more relaxed nervous system & clear focus

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Dustin
Dustin@r0ck3t23·
Jensen Huang just described how he plans to outlive his own body. Huang: “Very soon, I’m going to put a humanoid on a spaceship. And it’s going to be my humanoid.” His robot. His frame. Launched into deep space while he is still breathing. Huang: “Take all my inbox, take everything that I’ve done, everything I’ve said. It’s been collecting and becoming my AI. When the time comes, we’ll just send that at the speed of light, catch up with my robot.” Your body fails. Your data does not. Every email. Every decision. Every conversation. Recorded. Compressed. Compiled into a model that thinks the way you think. And when the biology gives out, that model launches at light speed to meet a titanium frame already cruising through the void. You do not die. You transfer. Sounds like fiction. Then he put a number on it. Huang: “Understanding the biological machine is not 10 years. It’s five years probably.” Five years to decode the human body the way we decoded software. Not treat disease. Decode it. Understand the entire machine well enough to patch it like a bug. Cancer is a bug. Alzheimer’s is a bug. Aging itself is a bug. And the compute to find the fix doubles every year. Huang: “It’s a reasonable thing to expect the end of disease.” He did not say hope for. He said expect. The man whose chips power nearly every AI system on Earth just told you the end of disease is not a dream. It is a scheduling problem. Huang: “It’s a reasonable thing to expect that pollution will be drastically reduced. It’s a reasonable thing to expect that traveling at the speed of light is actually in our future.” He listed these the way someone else lists quarterly targets. Items on a roadmap. Waiting on execution. But here is the part most people will skip past. And it might be the most important thing he said. Huang: “I’ve always had a great confidence in the kindness, the generosity, the compassion, the human capacity.” This is the man building the most powerful computing infrastructure ever constructed. The man whose hardware will power the intelligence that reshapes every industry, every government, every border on Earth. And his operating principle is not paranoia. It is trust. Huang: “Sometimes more so than I should. And I get taken advantage of. But it doesn’t ever cause me not to.” He has been burned. He kept trusting anyway. Not naivety. Evidence. Huang: “Vastly I am proven right. Constantly proven right. And often exceeds my expectations.” The doomers build everything on one assumption. Power corrupts. Humans weaponize every tool they touch. Huang has spent thirty years handing the most powerful technology in history to thousands of companies, researchers, and governments. His conclusion is the opposite. People want to do good. Give them the tools and they prove it. That is not soft. That is thirty years of data from the dead center of the compute revolution. Fridman: “What an exciting time to be alive.” Huang: “How can you not be romantic about that?” Romantic. Not optimistic. Not bullish. Romantic. Optimism is a prediction. Romance is what happens when you look at what is coming and it hits you somewhere deeper than logic. The end of disease. Consciousness uploaded. A robot carrying your mind past the rings of Saturn. Underneath all of it, a belief that the species wielding these tools is fundamentally good. That is what separates Huang from every other voice in this space. The fearful see AI and ask what could go wrong. Huang sees AI and asks how much suffering can we end. He is not dreaming out loud. He is reading the trendline and telling you exactly where it lands. Five years for biology. A lifetime for consciousness. And past that, a humanoid with your mind aboard, sailing through space at the speed of light. Built by a man who still believes in people. The cynics will laugh. They always do. Right up until the moment it ships.
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Tyson
Tyson@buildandhold·
@0neBlazer I have and I was unimpressed at the actual quantities it found in its takeoff.
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South Florida GC
South Florida GC@0neBlazer·
Has anyone in construction biz try using Claude AI for estimating?? I uploaded plans for a 3100sf addition and asked it for a comprehensive estimate and I am truly impressed. It created custom excel spread sheets and customized word file ready to present to the client. Woah.
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Tyson
Tyson@buildandhold·
@jonbrooks Where did you place your capital that now earns significantly more?
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Jon Brooks
Jon Brooks@jonbrooks·
I sold all my real estate investments in 2022–2023. Best decision I’ve made in years. The capital now earns significantly more — with less stress, less overhead, and zero midnight repair calls. Here’s what nobody tells you: Most investors quote gross numbers. Rent collected. Units owned. Portfolio size. They don’t show: • Net after expenses • Net after capex • Net after vacancy • Net after leverage risk • Net after time Gross is marketing. Net is reality.
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Tyson
Tyson@buildandhold·
@Jason Did you bottom tick this tweet?
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Adam Smith
Adam Smith@adamstatonsmith·
I’m having so much fun building. 🛠️
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Adam Smith
Adam Smith@adamstatonsmith·
Locked and loaded.
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Tyson
Tyson@buildandhold·
@AJA_Cortes Creapure is basically your only none Chinese option.
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AJAC
AJAC@AJA_Cortes·
I've been investigating creatine manufacturing It's only made in two places in the world, Germany, and China One company makes it in Germany has a total monopoly Multiple companies make it in China, and the past decade they've caught up to Germany in regards to purity It's not made in America at all because none of the pre-cursor chemicals are manufactured in the USA anymore To manufacture it in America again from beginning to end of a supply chain would require conservatively about $200 million in start up Capital
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Aesthetica
Aesthetica@Anc_Aesthetics·
Maybe a hot take but I'm convinced that the idea that nicotine is "highly addictive" was propaganda to stop kids from getting the benefits of nicotine. I can go weeks with Zyns, then weeks without and I don't notice a single thing. There is zero dependence, no withdrawal, no change whatsoever. I could quit tomorrow and not even notice I stopped. I get this is all anecdotal personal experience but I don't see how something that is described as "highly addictive" could just not be at all depending on the person. At most there's an oral fixation/boredom/habit forming angle but that's not addiction.
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U.S. Rep. Brittany Pettersen
U.S. Rep. Brittany Pettersen@RepPettersen·
Trump’s attacks on legal immigration are hurting Colorado’s economy. 60% of ski resorts rely on workers with J-1 visas, and many are now scrambling as they are unable to fill the positions needed. When we shut immigrants out, we hurt our local businesses, our tourism industry, and our economy. bit.ly/3LqK1eU
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nicolas, 30 ans
nicolas, 30 ans@nic_carter·
do we still like the eight sleep. what's the verdict
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Tyson
Tyson@buildandhold·
@rand_longevity 20g collagen peptides, mct oil powder & colostrum
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Rand
Rand@rand_longevity·
what do you put in your coffee?
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