C. Merlyn Anthony

@_dm_Darshan @NatureComms @Waghmarelab @ACTREC_TMC @CRI_ACTREC @biopatrika Congratulations Darshan and team🎉

Delighted to share publication in @NatureComms from my Ph.D. work !✨ Forever grateful to Dr. Sanjeev Waghmare @Waghmarelab for guidance and all the contributors. Thanks to @ACTREC_TMC for support. Article in press version ! share.google/r7mnCLXcCZmTb0… @CRI_ACTREC @biopatrika

Functionally distinct mitochondrial subtypes !! Congrats to whole team of Costas and Yatrik !! cell.com/molecular-cell… Molecular Cell cell.com/molecular-cell…

Mitochondria acidify lysosomes through membrane contacts @uofcincy @SunLabUCin sciencedirect.com/science/articl…

The mitochondria in a cell are weirder than you think. Not just “the powerhouse of the cell,” but more like a shape-shifting, constantly remodeling, mildly unhinged energy blob. #CellBiology

The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts dlvr.it/TP0NnC

Hyperactive 20S proteasome enhances proteostasis and ERAD in C. elegans via degradation of intrinsically disordered proteins | Science Advances science.org/doi/10.1126/sc…

Absolutely gorgeous! This is the kind of biological beauty responsible for setting the energy resistance (éR) level in your mitochondria, enabling the transformation of food into the energy that powers your energetic self. ERP: authors.elsevier.com/a/1luVK5WXUlaY…

Work from @CRI_ACTREC featured on cover of @FASEBorg journal! Image based on article: ATP-Driven Allosteric Regulation of 14-3-3: Positive Modulation of ATP Hydrolysis and Negative Regulation of Peptide Binding by Priyanka Bagdiya et al. from Prasanna lab doi.org/10.1096/fj.202…

Congratulations to Priyanka from Prasanna lab for this beautiful cover in FASEB journal that features their article below: faseb.onlinelibrary.wiley.com/doi/10.1096/fj… Congratulations Priyanka and Prasanna lab! @biopatrika

How do cells clean up misfolded proteins when they divide? This study finds that the cleanup crew includes the ER chaperone BiP and the proteasome, and kicks in right as cells finish dividing. Surprisingly, one major cell cycle regulator isn’t involved. elifesciences.org/articles/96675…

Geng, Verhey et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors hubs.la/Q03C7Dbz0

MOSAIC large field of view 3D single molecule localization microscopy of mitochondrial outer membranes and nuclear membranes in fixed U2OS cells.

Silencing mitochondrial gene expression in living cells | Science science.org/doi/10.1126/sc…. Wonderful that our paper is out now in Science. A big thanks to LD Cruz-Zaragoza and the team, @warscheidlab & @JakobsLab .

Human mitochondria connect with each other at a distance through thin membrane protrusions called "nanotunnels" As if they are "reaching out for help". Mitochondria in people with mitochondrial diseases show more nanotunnels in healthy mitochondria do. Below is one of the most beautiful image of nanotunnels we ever captured. Depending on your preference, this is either a single mitochondrion with four nodes, or four mitochondria interconnected network through three nanotunnels. More on mitochondrial nanotunnels here: cell.com/trends/cell-bi…

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at @CellReports! 🎉 🧫 New galactose #CRISPR screen 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂 Mito defects in #Menieres cell.com/cell-reports/f…

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes go.nature.com/4kSlPy6