Tim Shaw 🇺🇸..🇹🇼..🇺🇸

CGPA paper is finally out!

When polishing scientific figures for publication, I try to limit fonts + font sizes to reduce visual noise. But doing this by hand is tedious. So I vibe coded a web app to standardize text in SVGs: jef.works/SVG-Text-Stand… Try it out! Spot the differences. Hope it's helpful

#ScienceSaturday ❓ How can we turn T-cells into cancer-fighting “soldiers” without changing their DNA? ➡️ A new study in Nature Biotechnology introduces an all-RNA platform that can turn T-cell genes on or off using epigenetic CRISPR tools called CRISPRoff and CRISPRon. Instead of cutting or rewriting DNA, this method “reprograms” genes by adding or removing chemical marks — allowing researchers to boost or silence key immune functions safely. ➡️ The team showed this can enhance CAR T-cell therapies, helping immune cells better recognize and attack tumors while reducing potential side effects linked to traditional gene editing. 🌟 Congratulations to senior authors Alex Marson, Luke Gilbert, Brian Shy, and Justin Eyquem of UCSF, Arc Institute, and Gladstone Institutes for this exciting advance — a big step toward the next generation of precise, safer immunotherapies. 🔗 Read more in Nature Biotechnology: doi.org/10.1038/s41587… @LukeGilbertSF @UCSF @UCSFCancer @UCSFMedicine @arcinstitute @GladstoneInst @j_eyquem

A recent special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. Learn more: scim.ag/45xh33a

SmartImpute is now online with Cell Reports Methods cell.com/cell-reports-m…

RSG SE-USA presents America’s 3rd #ComputationalBiology Symposium taking place December 11–13, 2025 at the University of Florida in St. Petersburg.  This is a great chance for students to connect and plan for the future of the field!

If you’d like to present at the symposium, submissions are being accepted until Friday, August 15.  Contact and submission details are in the flyers!

Researchers have been sneaking secret messages into their papers in an effort to trick AI tools into giving them a positive peer-review report Read the full story: go.nature.com/4eVTIwC

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe, rapidly progressing genetic disease... all in an astounding 7 months. Best of all, the infant patient shows apparent benefit. Congratulations to @kiranmusunuru, Rebecca Ahrens-Nicklas, and other team members for this heroic and inspiring effort, which has implications for the hundreds of millions of patients that suffer from thousands of genetic diseases. drive.google.com/file/d/1Jfku5j…

Congratulations to Michael J. Schell, Ph.D., FASA. Well deserved! 🎉🎉🎉 #Moffitt #ASA #Biostatistics #CancerResearch

Using ROICellTrack on urothelial carcinoma, we identified distinct cancer-immune cell mixtures linked to transcriptomic & morphological signatures. Check out our recent paper with @song_xiaofei and @UrogerliMD. academic.oup.com/bioinformatics… #SpatialTranscriptomics

Thanks to the @KayYowFund we will be able to begin some exciting research challenging current treatment paradigms in ovarian cancer that will hopefully improve outcomes. Thank you so much for your generous support!

#MCBIOS2025 day 2 !! in beautiful Salt lake city @UUtah , theme - harnessing #artificialintelligence to transform #humanhealth. Dr. Tim Shaw @gatechatl and I will be co-chairing a session on #AI for #ImmunoOncology, featuring Dr. Linghua Wang @IamLinghua on her brand new published work #CAF, Dr. Xuefeng Wang @xuefwang #data harmonization for cancer #models, and Dr. AC Tan (not on twitter) @huntsmancancer president of MCBIOS speaking on #ditigaltwins. We will have 30 mins panel discussion at the end as well. Join us @ 11:00 Mountain time!! Exciting 🚀 slide credited to: Dr Tim Shaw

Drug tolerant persisters and immunotherapy persister cells exhibit cross-resistance and share common survival mechanisms biorxiv.org/content/10.110…

New #JITC article: Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients bit.ly/41hOvsq @gatechatl @MoffittNews

Off-the-shelf CAR-T is here! Our phase 1 trial in @JCO_ASCO shows allogeneic CD19 CAR-T cemacabtagene ansegedleucel (cema-cel) delivers durable remissions in R/R DLBCL: 🔹42% CR rate with median CR duration 23.1 months 🔹No GVHD, ICANS, or severe CRS ascopubs.org/doi/10.1200/JC…

One billion cells. 🚨 One incredible dataset. Together with @10xGenomics + @UltimaGenomics, we’re working to deliver landmark data to train AI models, advancing research in gene function, cellular behavior + understanding of health & disease czi.co/4hBZ5kM

#ScienceSaturday ➡️ Immunotherapies targeting neoantigens can be effective in mediating long-term durable responses in advanced cancer patients. However, identifying these neoantigens from metastatic tumors can be logistically challenging. 🧬 In this study, investigators looked at whether archived, preserved primary tumor samples could be used for neoantigen discovery. ➡️ The study found that primary FFPE tumor samples could be used to discover most of the neoantigens present in metastatic tumors and even unique neoantigens not present in metastatic tumors. 🌟 This approach would reduce the need for additional, sometimes complicated resections and expedite the time to treatment! These promising findings could pave the way for more accessible and personalized therapies. 🔗Here's the link to the full study: jitc.bmj.com/content/13/1/e… @NCICCR_SurgOnc @theNCI @jitcancer

@RiyueSunnyBao @OHSUKnight @IOTNmoonshot @RoswellPark Hey it’s Chi! Dr Zhang is one of the most brilliant scientist I know in bioinformatics.

Excited to welcome Dr. Chi Zhang (@OHSUKnight) to today’s #COWG lectureship, our monthly #Computational #Oncology Working Group co-hosted by @IOTNmoonshot @RoswellPark & #CIMAC-#CDIC! 🚀 Dr. Zhang took us on #an incredible deep dive into predicting #spatial & #temporal #metabolic #flux from #singlecell gene expression data. This cutting-edge #computational approach pushes the boundaries of #proteomics, #transcriptomics & opens new doors in #immunotherapy & #immunoOncology! 🔬✨

Great opportunity for undergrads!