James Halldon

@creatine_cycle moats are for princesses in castles. were going back to clogging our arteries with bacon and dying mid 30s

not only can AI now solve novel math proofs but now anyone can also just get skinny on demand. the moat for skinny nerds is drying up. time to get big arms and develop social skills

@sonofalli em dash users in shambles 😔🤙🏼

Obvious AI tells in your writing: - em dashes - not just x, but y - and honestly? - “leverage” “delve” “palpable”

@SlimSats the last season was weak by comparison but the finale had lots of redeeming qualities

@jameshalldon Is the new season good? Thought the last one fell off a bit.

@ishverduzco @NotionHQ 👀

Any NYC friends want to come to the @NotionHQ office next month? I’m hosting a mixer for Founders & Creators

@Litesout86 @huntclubhero it’s legit, BPC-157 has had similar anecdotes

@huntclubhero @jameshalldon You calling me a liar? Lmao 🤣

Finishing up my first peptide cycle of KLOW. All old and minor injuries/pain have gone away. July, I plan on trying MOTS-C to improve my endurance for CFT

@MINHxDYNASTY the market giveth and the market taketh

ARE THESE F*CKING WATCHES LIMITED OR NOT

@huntclubhero @paularambles best workflow we’ve ever had 🤝

@paularambles @jameshalldon and i been doing this for months

this is wild

@evaedxn @bryan_johnson Sauna and blood donations

@bryan_johnson how do we remove the microplastics that are already in us?

This new perspective study reports that our brains are carrying 3,000x more microplastic than our blood. Microplastic burden of the human brain rose ~50% between 2016 and 2024. The average brain now carries roughly: > 11x the load of the liver > 11x the kidney, and on a per-mass basis around > 3,000x the concentration found in circulating blood (on a per-mass basis) This study argues that eliminating ultra-processed foods (i.e. chicken mcnuggets, breaded shrimp) carries an additional benefit: reducing brain microplastic accumulation. This is based on an inferred chain of mechanisms rather than proven causality in humans, yet the convergence is striking. The paper outlines four pathways through which microplastics plausibly damage the brain: > oxidative stress and chronic inflammation > endocrine disruption > gut-microbiome injury > and vascular damage. These map onto various brain and mental diseases including: depression, anxiety, cognitive decline, stroke, dementia. The same conditions are independently linked to ultra-processed food consumption in large prospective cohorts Each 10% increase in ultra processed food intake > 25% higher dementia risk > 16% higher cognitive impairment risk > 8% higher stroke risk High versus low ultra processed food consumption tracks with 44% higher odds of depression and 48% higher odds of anxiety. While we do not yet have a human study showing UPF intake directly raises brain microplastic burden. Here is what we do have: A study found that the more processed forms of protein foods carry significantly more microplastic particles. > Chicken nuggets contained 31x more microplastics per gram than raw chicken breast (least processed item in the study) > Breaded shrimp, the most processed item in the study, carried ~130x the level in raw chicken breast (caveat: shrimp also carries higher baseline contamination from ocean and water pollution) > A 1,031-woman pregnancy cohort showed each 10% higher UPF intake tracked with 13.1% higher urinary phthalates, the plasticizers that leach from food packaging Microplastics cross from the blood to the brain. Animal research shows mechanistically how microplastic particles do cross the blood-brain barrier. In mice, polystyrene nanoparticles at 293 nm reached the brain within 2 hours of oral exposure. Particles at 1.14 μm and 9.55 μm did not cross at all. While most microscopy-based microplastic tests have a detection floor around 1 μm. The fraction that actually crosses into the brain sits below that threshold. If a test picks up larger particles in your blood, the smaller, BBB-crossing fraction is almost certainly there too, just below the detection window. The big ones are a proxy for the dangerous small ones. Cut all microplastic input where you can and avoid ultra processed foods, this another important one. In addition: use a water filtration system for your drinking water, reverse osmosis with remineralization is the gold standard. I recently reported complete elimination of microplastics from my semen (first in human demonstration) and a 87% reduction in my blood.

Unpopular but true: there is a sixth borough of New York. Circled for your convenience on the map, it runs from Ft. Lee to Bayonne and is colloquially known as the “West Bank”

thanks i hate it

@MeganNyvold they’re a massive pain in the ass, I just locked my card and called it a day

Is it legal for @solidcorestudio to not let me cancel or pause my membership directly on their website? I have been reaching out to their “ai chat”, email and text channel (also ai probably), with zero response and have been charged for 2 months now despite asking to cancel

@daniel_dhawan @rork @consumerclub_ @a16z would love to join

Attention: NYC consumer app founders @rork is sponsoring an event hosted by @consumerclub_ & @a16z It's a rooftop + open bar for a private happy hour in May. Current attendees are 1M+ ARR or VC-funded consumer founders Only a few spots left! Reply if you'd like to join 👇

@veggie_eric @titlejt this is my 9/11

genuinely hate that I can no longer use "—" in anything I write anymore

@MKBHD yes and we already do this

Ok genuine question: Would you actually trust an AI with your credit card to execute this in one click?

@LelloLemon i fear not the man who has sucked 100 dicks once, but I fear the man who has sucked one dick 100 times

Would you rather suck one 🍆 10 times? Or would you suck 10 🍆 1 time?

uber driver was bumping Adele so I jokingly asked if he was going through it now we’re going 110 on the way to the airport

@EnidPinxit Problem is costs will still balloon for the website, so they’ll put it behind an API, so then the bots will just pretend to be users again to avoid the costs, and then the platform will want to block the bots,,,,,,

I feel like platforms could start using markdowns or watermarks as the first point of entry to route agents or bots looking for information. Offer all the information up front on a platter, mark ads so they get bypassed. Could also trigger some kind of "this is a bot/agent" tag to the interaction.

@EnidPinxit it’ll be the only way moving forward, a gazillion tiers and many more gated features

@jameshalldon Probably more paid subs, ya. Even if the subscription is only $1 and tacked onto a purchase price, or part of incentives programs.

One idea i have about the dead internet theory is that all platforms will pivot to prioritizing paid subs for users via better features because advertisers will slowly begin running ineffective ads cause the real users on any given platform will be outnumbered by bots 10/1

Thank you SF, I’ll be back soon.

@sama goblin o1 goblin 5.6 Spark goblin 5.6 Codex goblin o3 goblin o7 Fast

what if we name the next model "goblin" almost worth it to make you all happy...