Jp Solar Vasconcelos

Why should tumor whole genome sequencing (WGS) be done for cancer? In real practice of medicine study of 888 patients with solid cancers, WGS directly led to clinical consequences in over 40% @NatureMedicine nature.com/articles/s4159…

The biggest cheat code on the planet is exercise and it's not even close. You get a better mood, improved brain function, hormone regulation, and better sleep all while looking great naked. If exercise were in a pill form, it would be the greatest drug on the planet.

🧬 More treatment is not always better in metastatic colorectal cancer. The phase 3 ORCHESTRA trial tested whether adding aggressive tumor debulking to systemic therapy improves outcomes in multiorgan mCRC. The answer: No survival benefit. 🧪 Trial design Patients with multiorgan metastatic colorectal cancer whose disease was controlled after induction chemotherapy were randomized to: 🔹 Chemotherapy alone 🔹 Tumor debulking + chemotherapy 📊 Key results Overall survival • 27.5 vs 30.0 months • HR 0.88 (NS) Progression-free survival • 10.4 vs 10.5 months • HR 0.83 (NS) ⚠️ Toxicity Serious adverse events were higher with debulking 53% vs 39% 🎯 Clinical takeaway In multiorgan mCRC, adding aggressive tumor debulking to palliative chemotherapy does not improve survival and increases complications. An important negative trial for MDT decision making. 🔖 Save for GI oncology discussions. 📖 Full paper in comment ⬇️ @OncoAlert @myesmo @esmo_open @asco #OncoTwitter #MedTwitter #ColorectalCancer #GIonc

📊 Research Summary: Among patients with multiorgan metastatic #ColorectalCancer, tumor debulking combined with systemic chemotherapy failed to provide a survival benefit over chemotherapy alone and resulted in higher rates of serious adverse events. ja.ma/4sok2oI

Why do cancer patients actually die? Often not from tumor mass alone. 5 major biological pathways drive mortality: • Organ failure • Infection • Cachexia • Thrombosis • Treatment toxicity Understanding these helps improve care and survival. #MVOnco #Oncology #MedOnc

Sem dúvida, os melhores minutos que vai ouvir nesse fim de semana. Professor Clovis de Barros. Fonte: universonarrado e g4educaçao

A single dose of antibiotics can have lasting effects on your gut microbiome, with changes that last well beyond 4 years. Three types of antibiotics stood out for their long term disruptive impact (3 at left, Figure) @NatureMedicine nature.com/articles/s4159…

Platelets fall just before the next oxaliplatin-based chemotherapy. What now? In a ph3 trial of GI cancers receiving oxaliplatin based ChT, Romiplostim allowed 84% of pts to continue ChT vs 36% with placebo; now in @NEJM nejm.org/doi/full/10.10…

In an international, randomized trial involving patients with acute venous thromboembolism, the risk of clinically relevant bleeding was significantly lower with apixaban than with rivaroxaban during the 3-month treatment period. Full COBRRA trial results: nejm.org/doi/full/10.10…

Time for another NET talk - this time on sequencing of systemic therapy. Another excellent @MayoMedEd offering. If you are looking for a good course in pretty much anything in Med Ed, check them out. They have a huge selection of quality courses, not just in oncology. So how to we select initial therapy for advanced NETs when resection or other regional therapy is not a good option...? Below are some thoughts, as always open to criticism and and comments (snarky comments also welcomed if you feel so inclined...). Come join us for future Mayo Clinic conferences!

Movement is medicine. Large systematic review of over 1,000 trials and 120,000 participants finds that exercise has a significant effect on symptoms of depression, anxiety, and psychological distress. We need to do a better job of integrating mental and physical health.

Obesity is linked to at least 12 cancers. Here’s part of the biology in @JAMA_current Dysfunctional adipose tissue becomes a pro-tumor endocrine organ, driving insulin signaling, estrogen excess, chronic inflammation, and immune suppression. In other words: obesity can help create the ecosystem cancer needs to grow. jamanetwork.com/journals/jama/… @OncoAlert

"A daily multivitamin slows biological aging." That's the headline from a new Nature Medicine paper. From a randomized trial! But when you actually read the data, the vitamin is doing just about nothing. Thread.

🧵 Rectal cancer is not one disease. Tumor location should shape treatment. A new JCO review argues that low- and mid-rectal cancers need different neoadjuvant strategies, with major implications for organ preservation, RT use, and QoL. 📍 Low-rectal cancers Goal: maximize cCR and preserve organ/sphincter whenever safely possible Relevant trials: RAPIDO, STELLAR, PRODIGE 23, OPRA, CAO/ARO/AIO-12 💡 Takeaway: TNT is often the preferred platform when the priority is watch-and-wait / organ preservation. 📍 Mid-rectal cancers Goal: avoid overtreatment, especially unnecessary pelvic RT in selected patients Relevant trials: PROSPECT, CONVERT, FOWARC, GRECCAR4 💡 Takeaway: In MRI-favorable, selected mid-rectal tumors, chemo-first or chemo-alone strategies may reduce long-term bowel, urinary, and sexual toxicity without compromising outcomes. 🎯 Organ preservation evidence base OPRA supports consolidation-based TNT for better TME-free survival. GRECCAR2, ACOSOG Z6041, OPERA reinforce that selected good responders may avoid radical surgery. Bottom line: Low rectum = intensify for cCR Mid rectum = de-escalate when safe That is the real shift toward precision rectal cancer care. 🔖 📖 Full paper in comment ⬇️ #OncoTwitter #MedTwitter #RectalCancer #ColorectalCancer @OncoAlert @ASCO @myESMO

40 years ago, a young physician submitted a paper reporting on the alteration of a gene called HER2/neu to Science. He didn’t know that it was the beginning of one of the most remarkable scientific stories of the human kind, which would eventually impact the lives of COUNTLESS patients with cancer — first via mABs, then through ADCs, bsAbs and beyond. Unforgettable Keynote presentation by Dennis Slamon at #MBCC26.

#Retreatment with #PRRT in advanced NENs by #DavidChan at @ENETS_ORG #ENETS2026 Long median time to rPRRT (92% >18m) And: 35% with radiosensiting chemotherapy • ORR 31% • mPFS 17.4m 👉Good results when patients are well selected

I have seen this error so many times A confidence interval crossing the null does not mean “no effect”. It means uncertainty around the estimate. Yet in this survey, fewer than 1 in 5 clinicians correctly identified an effect when the point estimate suggested benefit or harm but the CI crossed the null Time to move beyond dichotomous thinking sciencedirect.com/science/articl…

Nobody tells you this: Intelligence is overrated. Intelligent people are more likely to overthink, overplan, and overanalyze. They create complexity rather than doing the boring thing that works. The people you admire have a violent bias for action. Courage beats intelligence.

Higher intake of ultraprocessed foods at age 3 years was associated with more adverse behavioral and emotional symptoms by age 5 years, while replacing ultraprocessed with minimally processed foods was associated with better outcomes. ja.ma/4sqLF0k

Neoadjuvant gemcitabine–oxaliplatin, lenvatinib, and anti–PD-1 antibody led to longer event-free survival than surgery alone in resectable high-risk intrahepatic cholangiocarcinoma, with mainly low-grade adverse events. Full phase 2–3 ZSAB-neoGOLP trial results: nejm.org/doi/full/10.10…