joely

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joely

@joely

Orbis Tertius Katılım Temmuz 2007
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joely
joely@joely·
The EUA was a lie. We now accept that the Ioannidis study was valid. The actual COVID IFR was radically lower than the estimates in the WHO and Nature papers. And Early Treatment would have lowered it an order of magnitude further, invalidating the basis for the mRNA VAX EUA.
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joely
joely@joely·
@Jasmine_Keith You can always block them. And if for some reason that doesn't work, just hurl insults at them until they block you. As Ross Perot would say: "Problem solved." 😂
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Jasmine Keith
Jasmine Keith@Jasmine_Keith·
It’s bizarre how many large X accounts I’ve muted that just magically get unmuted and forced into my feed.
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The Bone Writer
The Bone Writer@TheRoadOfBones·
@Pirat_Nation Hmmm... Now I'm conflicted. Let's let them destroy the OpenAI data center and then... Send them a thank you note. 😁
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Pirat_Nation 🔴
Pirat_Nation 🔴@Pirat_Nation·
Iran threatens ‘complete and utter annihilation’ of OpenAI's $30B Stargate AI data center in Abu Dhabi
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Andy Blidy
Andy Blidy@ablidy·
Mesenchymal stem cells and repair In short, MSCs sit on the tolerance-and-repair side of the αDC1–CD4-DC–IL-12p70 teeter-totter but become licensed partners for immunity/attack + regeneration when the DC fulcrum is reset. Caravello positions DCs as the instructors directing attack and MSCs as the builders sustaining the battlefield; Blidy positions MSCs as Treg/tolDC amplifiers on the tolerance arm while stressing the need for balanced fulcrum instruction to avoid exhaustion or evasion. The αDC1 platform (as discussed across their posts) reboots the upstream instructor, restores IL-12p70 competence, rebalances the loop, and lets MSCs execute the correct program—whether suppressing pathogenic responses or supporting durable clearance and tissue repair. This is why their combined view sees stem-cell + immune-tolerance strategies (MSC-Treg synergies under proper DC instruction) as central to 21st-century medicine: one upstream reset, precise downstream immunity, attack, tolerance, and regeneration. Mesenchymal stem/stromal cells (MSCs) relate to immunity/attack versus tolerance in the αDC1–CD4-DC regulatory loop (the “immune teeter-totter”) and IL-12p70 as context-dependent downstream effectors: they are primarily tolerance-and-repair partners on the tolerogenic arm but become properly licensed allies for balanced immunity/attack + regeneration when the upstream αDC1 instructor is rebooted. This directly reflects the mechanistic framework detailed across Andrew Caravello (@andrewcaravello) and Andy Blidy (@ablidy) posts on X.Core Mechanism Recap: αDC1–CD4-DC Loop and IL-12p70 αDC1 cells are type-1-polarized DCs (ex-vivo matured via Kalinski protocol: GM-CSF/IL-4 pre-culture + TNF-α/IL-1β/IFN-γ/IFN-α/poly-ICLC) engineered for high bioactive IL-12p70 output. They capture in-vivo danger signals (unloaded or lysate-pulsed) and, after CD4+ licensing (CD40L feedback), deliver IL-12p70 at the synapse to drive Th1/CTL/NK responses. The teeter-totter (CD4-DC fulcrum): High IL-12p70 tips toward immunity/attack (adaptive CD4/CD8/B help); built-in restraints (IDO, PD-L1, IL-10, dose-dependent IFN-γ, NKG2A) plus innate-side inputs (NK/macrophages) prevent overload. Blidy’s “quantum immune teeter-totter” frames DCs/CD4 as the central pivot balancing innate (left: NK/PMN/macrophage) vs. adaptive (right: effectors) with tolerance as the default stabilizer.@ablidy IL-12p70 is the licensing fulcrum output: Above threshold it enables durable Th1/Tc1 memory; low levels default to tolerogenic/STAT3-dominant states. αDC1 ex-vivo culture reboots corrupted (age/disease) chromatin programs, restoring IL-12p70 competence and balanced instruction.@andrewcaravello MSCs in the Loop: Relationship to Immunity/Attack vs. Tolerance MSCs (bone-marrow-, umbilical-, adipose-, or iPSC-derived) are not instructors (that role is DCs/αDC1) but effector executors of tolerance + regeneration. Blidy and Caravello describe them as synergistic with Tregs and tolDCs on the tolerance side, yet capable of supporting attack when the teeter-totter is reset. Tolerance arm (default or low-IL-12p70 state): MSCs actively promote and stabilize tolerance. Via cell-contact (Jagged-1/Notch) and soluble factors (TGF-β, PGE2, IDO, IL-10), they:Induce/expand CD4+CD25+FoxP3+ Tregs (including TSDR demethylation for durable suppression). Reprogram conventional DCs into tolerogenic DCs (tolDCs) that further amplify Treg induction while suppressing Teff/Th17/NK responses. Suppress effector proliferation/cytotoxicity (downregulate NKG2D on NK, starve Teff via IL-2 consumption).@ablidy....This makes MSCs powerful for autoimmunity (SLE, MS, RA), GvHD, and transplant tolerance—Blidy calls MSC + Treg co-therapy a key future direction and notes MSCs sometimes hinder conventional CAR-T by expanding Tregs.@ablidy Immunity/attack arm (high-IL-12p70 αDC1 state): When the loop is properly tipped by αDC1-derived IL-12p70 → CD4 licensing → IFN-γ/TNF-α/IL-12 surge, MSCs do not simply suppress. Instead:They receive “licensing” signals from the same cascade, shifting to support regeneration without broad immunosuppression. MSCs secrete IL-10/PGE2 that extend DC survival and prevent premature exhaustion, sustaining the attack. In return, DC-derived IFN-γ/TNF-α/IL-12 modulates MSCs to home to damaged sites, normalize vasculature/stroma, and create an immunologically permissive microenvironment for T-cell infiltration and clearance. They explicitly frames this as synergy: DCs are “immune architects/instructors” that direct attack and memory; MSCs (and other stem cells) are “regenerative architects/builders” that repair the “room” so the immune orchestra can perform without collateral damage. Together they form a real-time feedback loop—DCs conduct, MSCs tune the acoustics. Regenerative coupling across both arms: Blidy repeatedly states that “regenerative medicine, stem cell and immune tolerance and immunotherapy will be stars of this century.” The IL-12p70 → IFN-γ axis from rebooted αDC1 activates tissue stem cells (including mesenchymal lineages) via STAT1, installs heritable epigenetic marks, and couples clearance (attack) with repair. MSCs thus mediate tolerance + regeneration or immunity + regeneration depending on fulcrum position.@ablidy Why the αDC1 Reboot Matters for MSC Function Corrupted states (aging, cancer, autoimmunity, chronic inflammation): The teeter-totter sticks—low IL-12p70 → excessive MSC-driven tolerance (tumor evasion or failed repair) or insufficient tolerance (autoimmunity). DCs send wrong instructions; MSCs receive faulty signals. αDC1 reset: Peripheral unloaded or appropriately matured αDC1 restores the instructor systemically. The resulting IL-12p70/IFN-γ cascade reaches tissues, properly licenses MSCs via the CD4-DC fulcrum for context-appropriate behavior: attack + repair in cancer/surveillance or tolerance + repair in autoimmunity/transplant. Caravello notes even pluripotent stem-cell precursors matured into αDC1 fall under NWBO’s IP-protected process, underscoring unified control over the instructor. No tissue-specific reformulation needed: MSCs read the same danger/tolerance patterns (calreticulin, HMGB1, etc.) that αDC1 captures. One upstream DC reset correctly instructs MSCs across contexts. Built-in Safety, Breadth, and Companion ToolsSafety: Transient mature αDC1 + five feedback loops (including MSC/Treg restraint) + Blidy’s emphasis on directionality (CD4→DC licensing) limit excess immunity or autoimmunity. Clinical αDC1 record shows no autoimmune encephalitis. Breadth: MSCs + αDC1 platform address cancer (surveillance/attack + repair), neurodegeneration, autoimmunity, and transplantation because the danger/tolerance pattern is upstream of the diagnosis label. Diagnostics (Blidy’s emphasis): Flow cytometry (CD4+CD25+CD127lo/FoxP3 multi-marker panels), TaqMan qPCR (FoxP3-TSDR demethylation), and intravital “8K movies” (live-tissue imaging of MSC-Treg-DC dynamics) monitor where the patient sits on the teeter-totter and confirm proper MSC licensing post-therapy.
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Andy Blidy
Andy Blidy@ablidy·
@RepTimKennedy Tim , I am in the process of getting my research paper on rebooting the immune system with alpha DC1 cells for any disease state …..cancer, autoimmune , cardiovascular disease etc. immune teeter totter …..one Dyu alumni to another
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Steve Kirsch
Steve Kirsch@stkirsch·
Please repost. Nobody knows this, not even RFK Jr. First autistic child diagnosed in 1932. Guess when aluminum was FIRST added to vaccines? Yup, in 1932, *before* the first case. What a coincidence!
Forrest Maready@forrestmaready

1) One of the most jaw-dropping discoveries I made while researching “The Autism Vaccine” took place in Austria. I was initially intrigued by the autism story when I realized that the first time aluminum had been used in a U.S. pediatric vaccine was 1932.

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Grady Booch
Grady Booch@Grady_Booch·
@shaunmmaguire Shaun, I reject the premise of your question. Many of us are rooting for integrity, the rule of law, compassion, and empathy, all things that this current administration is actively working against.
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Shaun Maguire
Shaun Maguire@shaunmmaguire·
How did we get to the point Where so many Americans are rooting against America?
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Truthseer💜
Truthseer💜@goldraysoul·
Was a beautiful day today❤️
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Wide Awake Media
Wide Awake Media@wideawake_media·
In June 2001, William Cooper—ex-naval intelligence officer and author of 'Behold a Pale Horse'—accurately predicted 9/11 eleven weeks before it actually happened. "Whatever is going to happen that they're going to blame on Osama bin Laden, don't you even believe it." "There's been a great awakening in this country that is gaining momentum. And so I can tell you with a certainty, they must do something terrible in order to stop this backlash." Four months after this radio broadcast, Cooper was fatally shot outside his home by undercover police.
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TRENDING ➞ 911
TRENDING ➞ 911@911NewsBreaks·
ALERT: 🚨 GOP Senator John Curtis reveals he WILL NOT back funding for continued military operations unless Congress formally declares war.
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Devuan GNU/Linux
Devuan GNU/Linux@DevuanOrg·
Groundbreaking OSINT investigation shows how three decisions by individuals with undisclosed financial interests permanently altered the identity infrastructure of every major GNU/Linux distribution running systemd
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Melgar Hymney
Melgar Hymney@LemmieMelgar·
“ok” and “okay” are two different things
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Mr. Macintosh
Mr. Macintosh@ClassicII_MrMac·
What a crazy #Apple50 birthday present! 🎁 iOS & iPadOS 18.7.7 (22H340) Apple stopped allowing iPhones and iPads capable of upgrading to iOS 26 to receive newer iOS 18 updates in December 2025, when iOS 18.7.3 was released. Who else is still holding the iOS 18 line like me?😅
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joely
joely@joely·
Apropos, what does "click" mean to you? Just mousePress? Or mousePress + mouseRelease?
John Carmack@ID_AA_Carmack

Act on press This is a UI design hill I will die on, and it dismays me how often and hard I have had to fight for it. Almost all interaction methods have a “press” and “release” event associated with them. Whenever possible, you should “do the thing” when you get the press event instead of waiting for the release event, because it makes the interaction feel substantially more responsive, and it reduces user errors by not allowing the focus to slide out of the hot box between press and release. Even a “ballistic tap”, where your finger is intentionally bouncing off the button or touch surface, involves several tens of milliseconds delay between the press and release, and most button presses have well over a hundred ms dwell time. There is a delight in interfaces that feel like they respond instantly to your wishes, and the benefit to every single user is often more important than additional niche features. Game developers, with simple UI toolkits, tend to get this right more often, but “sophisticated” app designers will often fight hard against it because it is mostly incompatible with options like interactive touch scrolling views, long press menus, and drag and drop. Being able to drag scroll a web page or view with interactive controls in it is here to stay, and nets out way better than having to use a separate scroll bar, but there are still tons of fixed position controls that should act on press, and it is good UI design to favor them when possible. In the early days of mobile VR, the system keyboard was a dedicated little OpenGL app that responded instantly. With full internationalization it became prudent to turn it into a conventional Android app, but the default act-on-release button behavior made it feel noticeably crappier. The design team resisted a push to change it, and insisted on commissioning a user study, which is a corporate politics ploy to bury something. I was irritated at how they tried to use leading questions and tasks, but It still came back one of the clearest slam-dunks I have seen for user testing – objectively less typos, expressed preference, and interview comments about the act-on-press version feeling “crisper” and “more responsive”. So, I won that one, but the remaining times I brought it up for other interfaces, I did not, and you still see act-on-release throughout the Meta VR system interfaces.

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joely
joely@joely·
@bradthx Retro brilliance! O.T. Did you know that the 8087 was remasked from the iAPX 432's 43202 (DMU)?
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Brad
Brad@bradthx·
I built a hardware multiplication accelerator for the 8086. It’s an ISA card built around a TRW MPY12HJ parallel multiplier from the 1980s that offloads MUL instructions from the CPU. It actually makes integer multiplication about 2.5× faster on early x86 systems. #retrocomputing #electronics #vintagecomputing 🧵
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joely
joely@joely·
@21WIRE His grift-compulsion embraces the event horizon.
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Patrick Henningsen
CONFIRMED: Dan Bongino is a deep state gatekeeper, and a bad actor.
Thomas Massie@RepThomasMassie

Dan, in your first call, which I think is the first and last occasion you and I ever spoke: (1) you seemed upset that I had received and had released FBI whistleblower information about the pipe bomb investigation. (2) I informed you that your staff had threatened to criminally investigate my staff as retribution against me (for pipe bomb or Epstein activity?) (3) you threatened to personally finance a defamation suit against reporters on behalf of a suspect. Perhaps it was also a veiled threat to sue me. You said “those depositions aren’t going to fun for the people involved” or something like that. In any case, Deputy FBI Director shouldn’t be financing civil lawsuits against reporters covering cases the FBI is working on. (4) you said you were going to call every agent in and get to the bottom of the whistleblower issue. (5) you offered me a briefing but I was going to be tied up until at least 6pm on the Epstein files transparency act, so I asked how late i could get the briefing and you said you were going to leave the office at 5pm. (6) I asked you a few questions on the call and your answers indicated to me that you were perhaps less informed than me on some of the issues, or you were going to be less than forthcoming. A few hours after the call, I received and released new FBI whistleblower information regarding the all-hands meeting (which matched what you told me in #4 above), related to concern that the meeting was called to “out” the whistelblowers. Your second (attempted) call was the evening I achieved 218 signatures on the Epstein discharge petition and I had been busy thwarting Mike Johnson’s last ditch effort to derail the Epstein Files Transparency Act. Not sure why your call log shows 1:36am. You called me in the evening, maybe 8ish? note - my staff also had the unfortunate pleasure of receiving numerous late night calls on Signal from FBI staff telling them there was absolutely nothing in the Epstein case and that I should back off.

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joely
joely@joely·
@21WIRE I find him viscerally unpleasant even when I agree with him on something.
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Robert W Malone, MD
Robert W Malone, MD@RWMaloneMD·
True story... "They show only that the bullet was too fragmented to confidently link it to ANY gun. This is not uncommon, and DOES NOT mean the bullet didn’t come from Robinson’s gun."
Colin Wright@SwipeWright

All the large accounts that present themselves as truth-seeking journalists or commentators, then quote posts like this and act utterly baffled—“What the hell!?” “WTF!?” “What’s going on here???”—are frauds. It took me less than a minute to see what the court documents actually said and understand what they meant. They do not show that the bullet was not fired from the gun. They show only that the bullet was too fragmented to confidently link it to ANY gun. This is not uncommon, and DOES NOT mean the bullet didn’t come from Robinson’s gun. Of course the defense attorneys are going to spin this as evidence that Robinson is innocent. That is what defense attorneys do. They scrape together every possible fragment of doubt and present it as if it were fully exculpatory. It’s not. Defense lawyers are paid to downplay or ignore evidence pointing to guilt, exploit people’s cognitive biases, and make fallacious arguments sound persuasive. This information about the bullet doesn’t erode the case for Robinson’s guilt in any way. It is totally neutral on that front. And it in no way invalidate the mountain of positive and mutually corroborating lines of evidence we do have for Robinson’s guilt. You should expect more from the commentators you follow, and hold them accountable by refusing to give them your attention in the future. If they could not be bothered to spend even one minute checking the facts before spreading confusion to you and millions of others on X, they do not deserve your attention. They are nothing more than grifting engagement farmers.

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