okazaki

@NIHDirector_Jay @drrichjlaw Ivermectin. Curcumin. Capsaicin. Love it.

NIH is proudly prioritizing drug repurposing as a way to accelerate research while using resources efficiently. Watch for some outstanding examples of how we’ve applied gold standard science to find new ways existing therapies can benefit more patients now:

@RealSunny97 @NIHDirector_Jay Ivermectin

@NIHDirector_Jay Somebody please figure out something for KRAS G12D. And don’t tell me ivermectin and fenbendazole bc we tried that and it didn’t work.

@nikitabier Wow you invented twitter

We’re rolling out summaries for Articles now. Just tap the Summarize button if you want to know if it’s worth your time to read it (or if your attention span is 12 seconds).

The F-35 was supposed to be unkillable. That was the whole point. Lockheed Martin spent thirty years and four hundred billion dollars, the most expensive weapons programme in human history, building an aircraft that the enemy simply could not see. Not on radar. Not on infrared. Not on anything. The F-35 was not just a fighter jet. It was a theological statement. America’s way of saying: we have moved beyond the reach of your missiles, your sensors, and your prayers. Iran apparently didn’t get the memo. Somewhere over Iranian airspace on March 19, 2026, an IRST system, infrared search and track, the kind of sensor your grandmother could probably explain, looked up, found the F-35, and locked on. Not because Iranian engineers are geniuses. Because the F-35, it turns out, is extremely hot. All that engine. All that thrust. All that carefully sculpted stealth geometry, and the bloody thing glows like a kettle. The heat signature data Iran now holds is not just embarrassing. It is a gift that keeps giving. To Moscow. To Beijing. To every procurement ministry on the planet that has been quietly wondering whether to spend the money on systems designed to kill this aircraft. The answer, as of this week, is yes. And here is the bit that should really worry the Pentagon. You can patch software. You can redesign coatings. You cannot reprogramme a pilot’s brain. Every F-35 driver who takes off from here on knows, actually knows, that someone down there might be able to see them. That changes everything about how they fly. Caution replaces aggression. Hesitation replaces instinct. Four hundred billion dollars. And in the end, it was done in by a heat sensor. Tremendous. Gandalv / @Microinteracti1

@FischerKing64 Such a bad take. They are cementing ecosystem lock in. Stick to your typical maga SH!t

Apple selling cheap laptops means it’s giving up on being an aspirational brand. Means it’s run out of ideas - which has been obvious for a while with the goggles and the thicker phones and iPads. It’s like if Mercedes entered the compact truck market.

La localisation du porte-avions français Charles de Gaulle rendue possible grâce à l'imprudence d'un marin utilisant l'application de running Strava, rapporte Le Monde. En faisant son footing sur le pont, il révélait la présence du navire.

This is common in other diseases (or when unethical to give PBO). Time for active comparator is here.

Translation: Given that the US has now effectively run out of stand-off munitions, they finally ordered an F-35 sortie into Iranian airspace. The "stealth" aircraft was detected, targeted, struck, and was lucky to make it back to its base in one piece.

@AppleHelix @RxRegA Looks like your boy you’ve been groveling over might be doing his next stint patching up shivings in prison

Claude was able to find Vinay Prasad's CV from 2023 (for tenure application?). onlinelibrary.wiley.com/pb-assets/CV%2… VP actually received 2 separate grants from the Arnold Foundation. One from 2017-20, the other 20-23. And probably is still supported by the foundation. Total from 2017-23 was ~$4m. Most recently, the foundation was funding VP $800K per year.

Cash Dubai crude (balance of the month) just broke above $170 per barrel. To my knowledge, no crude has ever commanded more than $170/bbl before.

Last year, Donald Trump Jr. invested in a rare earths startup at a $200 million valuation. Then three months later, the US government announced a huge loan backstop for the company and now it's worth around $2 billion. bloomberg.com/news/features/…

Bessent: "We unsanctioned Russian oil ... in the coming days, we may unsanction the Iranian oil that's on the water"

@SukritGanesh @pitdesi There were two attacks.

The 747 gift from Qatar to Trump could be one of the best investments of all time. (& completely fd up)

Whether you like him or not, whether you thought he was a good or a bad Fed Chair, you can’t not admire the incredible fighting spirit of JPOW. He is standing up to that fat fuck with rectitude, fortitude and a steadfastness that forces respect.

“Although President Donald Trump says he has ‘destroyed 100% of Iran’s Military Capability’, the 0% that remains is playing havoc with the global economy.” -The Economist

QatarEnergy Statement on Missile Attacks on its LNG Facilities In addition to the previous attack on Ras Laffan Industrial City on Wednesday 18 March 2026 that resulted in extensive damage to the Pearl GTL (Gas-to-Liquids) facility, QatarEnergy confirms that in the early hours of Thursday 19 March 2026, several of its Liquefied Natural Gas (LNG) facilities were the subject of missile attacks, causing sizeable fires and extensive further damage. Emergency response teams were deployed immediately to contain the resulting damage with no reported casualties. QatarEnergy will continue to communicate the latest available information. #Qatar

there really is a "fix everything right now" button for buying a printer and its been the same for 20 years

this is the first major mention i've seen of arnold venture's influence on this fda. arnold is said to be have been a major backer of prasad's research (i don't have proof of this, have just been told many times), and as wsj notes, szarama worked at arnold before prasad brought her in. most aren't aware arnold ventures was the major backer of ICER, the group that defines the value of medicines for the UK (which is set at a cap of roughly 30k pounds per human life year). it is also the reason the UK has dropped below basically all other developed countries when it comes to access to rare disease medicines. in short, arnold doesn't believe rare disease medicines are worth it, and it's natural to conclude prasad and others were bringing that philosophy to fda. now it's fine to have that view as a society (as the UK chooses to), but the trump administration represented the opposite, which is to accelerate access to rare disease medicines. wsj.com/opinion/one-ex…