UnPCThreads

@SignalLiberty @bryan_johnson Because viruses never mutate...

@bryan_johnson If it turned to a global threat, they’d be awfully suspicious because you can’t contract hantavirus from one human to another!!

If Hantavirus mutated into a global threat, it would unleash AI + biotech unlike anything we've ever seen. > genome sequenced and public in 4 hours > AlphaFold maps every protein target > AI screens 10,000 drugs in 24 hrs > 50 vaccine candidates designed simultaneously > AI designed antibodies in days > risk of death computed instantly > decentralized trials launch globally > enroll from home > 20 countries manufacturing at once > first doses in three weeks > real-time dose characterization > your genome + biomarkers determine your protocol > variant map updates every hour No one would wait for governments.

@SilentlyPissed @AdamKinzinger @mazemoore I'm willing to bet that Congress spent the money when Obama was president. Trump makes up BS like 'donations will pay for this', and then illegally take money from other appropriations.

@AdamKinzinger @mazemoore Then so did Obama if he spent $34M on it. There was also a $300M project proposal for full reconstruction under Obama. 🤦‍♂️ See my avatar for a double face palm

2012. CNN does a segment on the complete failure of Obama's 2 year, $34 million reflecting pool renovation. This was less than a month after the reflecting pool reopened. Notice how CNN didn't blame the Obama in any way. They would treat Trump the same way right?😜

@YourAnonOne Stop making shit up.

CIA whistleblower testifies under oath that Anthony Fauci was directly involved in covering up the origins of COVID-19.

@BluBlzer @unusual_whales Vermont and Rhode Island balance out WY and Alaska.

@unusual_whales Well, when a state like Wyoming has only 100,000 people. Less than the threshold for one congressional district, but has two us senators, the US Senate will never represent the interest of the American people and will continue to tip in favor of Republicans.

There is a 54% the Republicans will win the Senate, per Polymarket:

@irat1onal @MTSlive @maxmarchione Many aging pathways are preserved across species. It would be worth taking even if it's only proven to work in mice. What's the downside?

Assuming someone came up the ultimate "longevity peptide potion" today to get someone to 130-140, even if you started testing it out on a cohort of octogenarians in 2026, we are still talking about waiting until the 2080-2090 timeframe to see if it even worked - there are unfortunately some things you can't just compress...

We asked @maxmarchione how long he thinks lifespans will go to. "I think in the next 10 years we might be able to move the needle on lifespan to around maybe 130 reliably." "What we might see is it's very hard to break the biological cap of 140." "Of 60 billion people to live on Earth, we don't have a single documented case of someone living to 140, which is actually pretty crazy." "So we might see there's actually a cap and it's very hard to get beyond it, or we might see the opposite, which is, we're gonna create super intelligence, and super intelligence is gonna find ways to extend human lifespan to very large numbers." "Like, we're talking into the 100s, maybe even towards the 1,000s."

@grace_vera01 @RepYassAnsari Biden didn't make Epstein a cornerstone of his campaign. Trump did.

Your party controlled the House, Senate, and White House for four straight years and never once forced the full Epstein files into the daylight. Now that Howard Lutnick is in the Trump administration, suddenly a closed-door transcribed interview is the “most egregious cover-up in American history”? The selective pearl-clutching is almost impressive. Maybe focus on the actual files your side buried instead of grandstanding over one deposition.

Today’s deposition with Howard Lutnick should have been recorded and released for the American people to see. Why wasn’t it?

@grace_vera01 @RepYassAnsari For 2 years; GOP won the house in 2032.

@DrNeilStone What's the likelihood of it becoming easily person to person transmittable? 40%? F*ck, that's worse than smallpox.

Hantavirus has a fatality of up to 40% There is no treatment Normal people : WE NEED A VACCINE Anti vaxxers: NO VACCINES I'LL TAKE MY CHANCES

@MattZirwas What are your thoughts on peptide skin creams like oneskin?

I kind of forget about it because I'm thinking people, at least most people, would rather be alive and wrinkly than dead and smooth. But that's a false dichotomy - it does play into the risk benefit calculation - and I get what you're saying. SPF30 mineral to your face every day prevents most of the important photo aging without really affecting the cardiovascular benefits

Dermatology is wrong about the sun. And it's killing people. I'm a dermatologist. 226 publications. I should know. Avoiding the sun increases the risk of dying as much as being a smoker. We can fix it. For decades, dermatology's message has been simple: avoid the sun. Wear sunscreen. Seek shade. UV causes skin cancer. End of discussion. That message is incomplete and outdated. People are dying because of it. Lots of people. The evidence has gotten strong enough that the field needs to update it.🧵

@OfirPress @Tim_Dettmers What harness are you using?

1) Our team at Meta has a tough new coding benchmark challenging models to code entire programs including ffmpeg and the PHP compiler from scratch. 2) Top accuracy is 0% 3) We will be making the benchmark harder.

@MattZirwas Skin cancer isn't the only downside of sun exposure. General damage/premature aging seem like even a larger concern. Though 30 minutes a day doesn't seem all that bad.

@pc_threads Man that's a good question. Been waiting for someone to ask. It's a risk risk-benefit calculation. Skin cancer risk depends on skin type and how you get the sun. Benefits likely plateau, we don’t know where. My bet: 30 minutes a day to a large body area gets you most of it.

@MattZirwas So is there a U shaped curve where too little and too much sun is bad? Or rather, how much is too much?

Latitude matters for UV intensity, but the dose-response works within any population. Korea (37.5°N — same as central US) showed 36% fewer cardiovascular events with intentional UV in the vitiligo cohort. The US dialysis study (342K patients across all latitudes) showed UV directly lowered BP independent of temperature. The mechanism — skin nitric oxide release — doesn't switch off near the equator. Sun-avoidant people in Miami still benefit from more sun than they're getting.

@ivangdavila @OpenAIDevs 😂 fair enough. That's still the only thing I use. Get off my lawn with your fancy apps

@pc_threads @OpenAIDevs Only the CLI

It’s 5/5. What are you building with GPT-5.5?

@deedydas What harness was used?

The creators of SWE-Bench just dropped a really simple new benchmark every LLM gets 0% on. ProgramBench asks: can models recreate real executable programs (ffmpeg, SQLite, ripgrep) from scratch with no internet? We are far from saturated on model quality.

@davidasinclair @Cell_Metabolism You mean 1/5th as much? 5 times less is like Trump's 600% cheaper.

We now exercise five times less than we did 100 years ago. Our lifestyles are accelerating aging New review @Cell_Metabolism how to counter it cell.com/cell-metabolis…

@ivangdavila @OpenAIDevs Isn't codex already open source?

@OpenAIDevs Open-source Codex alternative

@beffjezos 😂😂😂

One man vs one nation. My bet is on Elon to win.

@PeterDiamandis @elonmusk So never

Wow! Given @elonmusk new comp package he will likely be worth $3.5-4T when SpaceX hits $7.5T, with a bonus worth an additional $500B+ sitting there waiting for 1M people to move to Mars.

@hughhewitt @POTUS You're talking about Trump and the 25th amendment right?

“We cannot let lunatics have a nuclear weapon.” @POTUS @realDonaldTrump/116502605614258580" target="_blank" rel="nofollow noopener">truthsocial.com/@realDonaldTru…