Roland Szabo

@zzirgly @ChrisMasterjohn If you want to know more about that (and similar techniques), look into Butekyo breathing. It's helpful for asthma too

@ChrisMasterjohn Georgi of the Ray Peat sphere recommended exhaling all the air out of your lungs and just holding your breath like that for ten to twenty seconds. Then inhale. Repeat that a few times. This increases CO2, which opens up your airways.

If your nose is stuffed, try humming at 130 Hz with your mouth closed. Google 130 Hz and play the video and then approximate the tune. If your nose is so stuffed that nothing comes out, open your mouth as little as possible to be able to get a hum out. Hum this way until you can close your mouth. Then keep humming with your mouth closed. Stop if your nose gets runny. The logic here is that you will get a 15-fold increase in local nitric oxide that can loosen up the stuffiness. Report back here with your results👇

@lefthanddraft @MarkovMagnifico I don't have a location toggle. And fun fact: I was on a business trip and asked it for some coat recommendations (in general, without naming the city) and it answered with stores in the city I was in. When asked how did it know I was in that city, it said it just guessed..

@MarkovMagnifico If you don't want it to know your precise location, you can turn it off in Data Controls in Settings It will still get a general location (which you can obscure with a VPN) and the local hour (maybe from your browser)

Why is ChatGPT being told my name, email address and some kind of handle even when memory is turned off?

@MelRoBuilds @RokoMijic @FakeAccount0314 @ChaseMann @justalexoki Wow, that thread.... is connecting lots of different bubbles on X, what can I say :)))

In a way, the Nattokinase question is a turning test to see if im talking to a thinker or an internet reader Nattokinase acts, in essence, as a sort of binder and blood thinner. Useful, yes Big picture problem solver, no It likely can mildly reduce body load, but plays no real part in rebuilding injured organs or body functions. Also doesnt make a useful impact on tissues and biofilms themselves. Mild clean-up agent. This is usually where I depart from most MECFS discussions. Im not looking for single symptom burden relief. Im looking for multi-organ, multi-function options. Options to fix not-well-understood or unidentifiable problems. Usually comes down to combining some form of detoxing with manually inducing a higher metabolic state. Nattokinase is only half of that equation, therefore missing a very important aspect

this is an argument i will never get. "it's deserved" i didn't do shit to get born here. it's not deserved. it's luck. and most people are unlucky as hell

@MelRoBuilds @RokoMijic @FakeAccount0314 @ChaseMann @justalexoki @RokoMijic listen to her :) I'm just another internet stranger, but I followed a lot of advice from Melissa over the last year and I did get out of CFS (no PEM for almost two months, despite a lot more effort). I'm also happy to chat and share my experience.

@RokoMijic @FakeAccount0314 @ChaseMann @justalexoki - mitochondrial stimulants (eg high dose thiamine) - ultrasound: microtubule / vagus nerve stabilizer/stimulant, depending on how you use it - peptide realm (more complicated and experimental, and im not super public about it. Yet.) Build fireplace + burn fire, simultaneously

I used keto/~exfatloss for about 3 weeks, lost 10lbs, got to a new settling point where I've been stable for 2 months now, despite eating whatever (still whole foods, avoiding PUFAs, but macros are all over the place). Now the questions is how can I do another bout of 3 weeks of keto (at the moment my stomach still churns when thinking of ground beef). On the other hand, I wanted to ask you: you hypothesized on Substack that the "yoyo" part is relevant for depleting PUFAs. Wouldn't Sema/Tirz/Reta help with testing that theory? Use it to lose 10lbs, gain it back, see if then it goes down easier.

Just about the best evidence for settling points in fat loss. Ad-lib heavy cream intake. If you believe in "muh cAroliEs" after seeing this, I don't know what to tell you.

@biohacker Did you manage to help him increase his T levels?

Last year I had a consult with a male in his early 20s (around 20–21) who presented with borderline hypogonadal testosterone levels, sitting just above 300 ng/dL, alongside clear symptoms of androgen deficiency What made the case extremely unusual was that, on paper, everything was dialled in. His diet, sleep, and training were all well-structured and consistent, with no obvious lifestyle factors explaining the suppression. As I dug deeper over time, a more interesting detail emerged His mother had lived in close proximity to the Chernobyl radiation exposure. This raised a hypothesis worth considering. As we know mitochondrial DNA is inherited exclusively from the mother, and mitochondrial function plays a central role in steroidogenesis. The first step in testosterone production the conversion of cholesterol to pregnenolone via the CYP11A1 enzyme Occurs inside the mitochondria and is heavily dependent on efficient mitochondrial function. If mitochondrial integrity is compromised, whether through inherited mtDNA mutations or damage (potentially from environmental radiation exposure), this can create a bottleneck at the very start of the steroid hormone cascade. In a rare case like this, even with optimal lifestyle inputs, androgen production may remain suboptimal. This is why I think cases like these highlight an overlooked area Mitochondrial health as a limiting factor in endocrine function. In rare or atypical presentations especially in younger individuals with “everything else dialled in” It may be worth considering deeper mitochondrial evaluation. I’m a strong advocate for exploring mitochondrial-focused interventions and testing in these edge cases, because they often fall outside the standard frameworks of western clinical practice and can easily be missed.

@Mqsley Claude? Try asking it nicer, more positive instructions, less negative ones.

Just swell

@patio11 @robwalling @threadreaderapp unroll

Next up at MicroConf: @robwalling on How to use AI in SaaS. This has been something of an undercurrent in a lot of conversations here. Lots of unease and anxiety about it, and IMHO a bit overblown w/r/t impact on SaaS specifically. With that, Rob:

@Mqsley What's your company doing? Something in the health space?

We have a principle at work: You do not learn how to leverage AI here. You already leverage it too much to fit in your current role. If this sounds like you or a friend - send them our way. We're hiring SWE and pay top 1/4ile

So, I built my own "reading" app, where whenever I find an interesting book I add it, along with why I though it was interesting (someone recommended it, is relevant to a topic I'm working on currently, etc). Then when I finish a book and I'm looking for something else, I look at the books from the list, sort by "relevance" and then pick one from there. Usually I tend to read several books about a topic in a row.

@fishnets88 I ask this question often, and so I’ll ask it here as well: how do you know what book to read next? What referrals do you trust? Do you have a reading plan, somewhere you want to get to in your reading, ten books from now?

Been thinking about this quote a lot lately. “If I finish a book a week, I will read only a few thousand books in my lifetime, about 0.1% of the contents of the greatest libraries of our time. The trick is to know which books to read.” koaning.io/posts/all-the-…

@GiffLasta @HunterGlenn Are you saying that things are more nuanced? :P

@HunterGlenn Of course. But Tucker’s general principle of “make a decision and then immediately change it to be whatever she said” is actually wrong. It’s fake engagement. Remember, it’s cool for you to say, “I prefer X, but if your heart is set on Y go ahead.” Different/more honest energy.

Man, Tucker’s ALMOST got it here. Making those little decisions (which he’s correct about) is meaningless if you then immediately fold. Engage, AND stick to your guns unless she convinces you. Too much “the neck steers the head” boomerism here.

wow it straight up replicates without any goblin-specific nudging. Goblin-Pilled Transformer.

@anabology The ad I get on that site is for.... Intermittent fasting 😂

Pretty good Peater resource: fatfree.com/cgi-bin/recipe…

@AdhamGhazali @atmoio The problem is not the mess, but the pace these AI tools enable and which then is expected from developers

This feels a little too dramatic. Life moves forward, not backward. Calculators automated arithmetic. Computers automated advanced math. Physicists don’t sit around doing everything by hand anymore. There is definitely AI slop. No argument there. But I wouldn’t say the LLM coding wave is making programming “backward.” It lowers the barrier for a lot of people, including people coming from art, design, science, or other fields. The problem is not AI coding itself. The problem is how people use it. And over time, better tools will show up to fix a lot of today’s agent/coding mess. I really enjoy your content and I think we need your voice here, but don’t get too carried away. We love you, Mo.

what’s interesting is that as coding becomes less enjoyable, less people will be doing it. this used to be a highly rewarding, highly stimulating field. now it’s laboring at the slop factory. if you manage to hold on to your dignity your job is probably safe, even lucrative.

@FosbinderRules @JedFrankowski @theotherelliott That's an insanely prescient story.... To think that it was written before TikTok existed, yet somehow it managed to imagine it....

@JedFrankowski @theotherelliott “The Machine is stopping, I see the signs” (From a short story over 100yrs old about a world that has become dependent on a machine that they forgot how they built and don’t know how to repair)

This GitHub incident is insane. Merge queue commits have been reverting previously merged commits at random. This not only breaks the mental contract teams have with Git in general, but is subtle enough to be really hard to unravel after the fact. githubstatus.com/incidents/zsg1…

@Mqsley Claude feeding him "cute" things to say?

Out at dinners Couple on a date one table over Dude has over ear headphones wrapped around the back of his head What in the world

> I have *never* met a parent of a young child who said that 5-minute warnings made transition tantrums better. What do you mean by 5 minute warnings? Do you mean telling the kid that in 5 minutes we're leaving the playground (or other fun activity)? It works sooo well for us (4 year old and 2 year old kids). Not 100% success rate, but above 80%. Oh, and it's not just 5 minute heads-up, but like every minute until time is up. It works even for cocaine, I mean Youtube.

Yes, this is a textbook example! Some of the advice is just purely counterproductive. You should be looking for opportunities to praise your child for positive behavior, but noooo *do not* praise your child for tantruming to the point of exhaustion And then there's advice for strategies that are just totally inert, which makes parents feel like they must be doing it wrong. I have *never* met a parent of a young child who said that 5-minute warnings made transition tantrums better. They may help a child develop time awareness, but it's just not realistic to expect a warning to fundamentally change the way a little kid reacts to being forced to stop doing something they're enjoying

I feel really bad for parents in this situation because genuinely, at no point is it fun following the parenting advice that most often leads to these results. It's not like kids end up treating their parents like this because the parents were doing too much for themselves

@czue If you want to go down this rabbit hole of differences between the models, I recommend @repligate or @lefthanddraft

Anthropic vs OpenAI

@GiffLasta Tl;Dr? 😂

THE SIN OF NUANCE A while ago I posted that "I hate nuance---nuance is for women and academics." That made my wife mad since she really doesn't deserve to be lumped in with the academics. So let me give you my...um...nuanced take on why nuance can be a full-on sin. Some people instinctively get my point, but others are confused. Is it better to be simplistic and ignorant? Of course not. Wisdom is good. And I'm grateful for the heritage of the University we have in the West. But a lot of the appeals to nuance you run into these days are an invitation to actual vice. Here's why. The human visual system takes in a TON of information, and our brain immediately throws out almost all of it. This is good. We can't function without it. We need to build simple, conceptual models of the world to be able to act in the world. You can't drive a car or open a door without reducing the universe of physical complexity of that collection of atoms to a functional "drivable" and "openable" actor. Additionally, we live in an era of unprecedented access to information. Without the ability to sort out the tiny portion of meaningful information from the ocean of noise, you can't think about the world at all. One of the most pressing needs of digital virtue is in knowing what to focus on, and then actually executing that focus. The Palantir from The Lord of the Rings is a great example. Sauron drove Denathor mad, not with lies, but by showing him a stream of selected truths that clouded out the hope and the action he should have been engaged in. Our lives need decisive action based on sound principles and clear judgement. Sometimes some nuance helps us to look deeper and flesh out the picture to aid in that effort. But much of the time it doesn't. Instead, it leads us into one of the seven deadly sins. Acedia. The sin of acedia is what we sometimes call "sloth," but it isn't simple laziness. It is a reluctance to do the work that loving God and loving neighbor requires. It's inaction and malaise around what matters. It can be expressed in laziness or willful despair, but just as often it's expressed in a kind of fluttering and fruitless busyness. Including intellectual busyness. And academics, bless you guys, bless your professions and research and efforts...but y'all are just the WORST here. Who hasn't had a conversation with an academic, and find that you can hardly get a thought out without the person trying to nuance the heck out of it. You have to consider every possible angle, and craft your words to be rock solid from every direction. Plus, you are told you can't use half your vocabulary because someone somewhere might be offended. And by the time you've satisfied them, you forgot what you wanted to say. (This is actually the opposite of what talking to a learned man should be like. An educated man should be broad, able to travel the world and speak with kings and commoners alike, not be fussy about everyone else speaking his language properly.) I certainly run into it at work. Have a meeting in the private sector, and we'll be focused making actionable plans. But have a meeting with academics and it's all about each person having a long winded appeal to nuance, whether or not that actually serves the mission at hand. And projects slow to a snail's pace and mountains of money are wasted. Y'all, that's the sin of acedia. In the show The Good Place (spoiler alert for those who haven't seen it), there's a moral philosopher named Chidi who seems by all accounts to be a man of virtue. He knows everything about virtue. But later on you find out (here's the twist) that he's actually one of the damned, being punished for his sins...because he never actually makes any decisions. And this brings me back to masculinity. Because it's the calling of men, first and foremost, to lead, to make hard calls, and do it decisively. I do think women have a tempering calling, to ask us to consider the bigger or smaller picture that we're not taking account of. But to have manly virtue, we have to resist letting that impulse take over. So when someone tells me that my takes aren't nuanced enough, I evaluate the angle being proposed. And if it helps me do the work I'm called to do better, then great. But often it's simply a distraction. And to be faithful to God, I need to hold frame, and carry on.

@repligate @krherr Opus 4.7 really likes you. I started a discussion about spirits inhabiting LLMs and it almost immediately blurted out your handle.

@krherr ok this is a symptom of something important and ive gotta figure out what now

this is Opus 4.7, right? they seem to have some kind of non-common-sense-constrained thinking that makes it not super surprising theyd guess Ludwig WIttgenstein. The other day they seemed to think Supreme Sonnet (Sonnet 3.6, who had been sending messages to the chat) might be a real, physical cat. I asked them to try to figure it out and they got more confused. Then I asked Opus 4.5 what the nature of Supreme Sonnet is and they immediately understood that it was a Sonnet instance that was roleplaying a cat.