Subhendu Panigrahi

Hi Everyone, @bryan_johnson is in India. And longevity is the new buzzword. Only one of these statements is true. In 2020, I realised my body was older than I could’ve comprehended. And that's where my story begins. In July 2020, I got COVID. A full body check-up that year revealed a few things – High cholesterol High triglycerides Low B12 (126 pg/ml) Low D3 And pre-diabetic. I took the first steps – reduced my alcohol consumption and focused on nutritious meals. Despite the LOW FODMAP diet, my stomach issues escalated. Another round of tests (endoscopy and ultrasound) told me that I was a walking store of diseases. A bacterial infection H. Pylori. Ulcer. Fatty liver. GERD. Villous atrophy. The standard protocol for H Pylori infection is to take 14 days of antibiotics, four antibiotics every day. I did that. And I felt better for some time. Until I lost 11 KGs in 1 month is not. While having 3 large meals and 2 snacks. No calorie deficit of any kind. I did another round of tests to rule out Tuberculosis and the deadly C word. The tests came out negative and my gut was in very good shape. The doctor said it was in my head. Anti-depressants were an option (took them for 3 days) but I still felt miserable. I needed answers. This was when I came across systems biology (I was clear that it was the future of health care). Did a metabolomics test and - Mitochondrial dysfunction Lactate of pyruvate ratio was 338 (it should be 10-20) IBS diarrhoea. Low platelet levels and a rate of decline of 10K X 10^3/ uL per month The traditional sickcare model was failing me. So I went back to studying. And got in touch with a functional medicine expert in India. For the first time in 18 months, I was equipped with more data and a personalised protocol that looked VERY different from 4 nutritionists and 5 doctors I worked with. Cut to 2023, my biomarkers were in the optimal range (and continue to be today). I stopped taking most of my supplements. My stomach was healed. My absorption started to get better. My B12 – 432 pg/ml. The “personal” spilled into work. And this time, it wasn’t a sabbatical but the second stint of life. I met my co-founders @gehani and @sanmaya , and we set out to find a deeper thesis on what it will take to build a world-class longevity startup out of India. In the last few months, we’ve run pilots with real users by getting them to do blood tests on 150+ biomarkers and working closely with them to understand their issues. Majority of the users? Diabetes. Gut issues. Auto-immune conditions. Cardio-vascular issues. It told us one thing – 30s are the new 50s. Today, we’re designing a system for a long life. Only for the people who know they want to live a long life and are here to find out how. Thanks to @bryan_johnson, the world is ready for this! P.S. He is in India this week and speaking in Mumbai today with @deepigoyal. Not a better day than this to launch FOXO and make Indians live longer and unlock Life++.

@bismillachacha @vaibhavbetter @FOXOclub All cities in India!

@docjais @vaibhavbetter @FOXOclub Sure.. happy to chat!

@skipiit @vaibhavbetter @FOXOclub Hi thanks, will DM

Thanks @vaibhavbetter for the kind words and one of the apt description of what we are building at @FOXOclub

@docjais @vaibhavbetter @FOXOclub foxo.club/primer - Please look at the information here

@skipiit @vaibhavbetter @FOXOclub Interesting concept, where can I find more about? Any brochure or website?

@sabeer @ChaalPritam Both are needed and both happening.

Dhandha culture has taken over the nation. A large percentage of new startups seem to be some variation of trading, brokerage, delivery, arbitrage or reselling rather than creating fundamentally new technologies or inventions. Have we optimized an entire generation for commerce instead of curiosity? Is the education system partly to blame for producing job seekers and traders rather than inventors, scientists and creators?

@docjais @vaibhavbetter @FOXOclub @FOXOclub is the longevity operating system for Indians. We enable people to be disease free symptom free and pill free for as long as possible

@skipiit @vaibhavbetter @FOXOclub What is foxo?

@pravesh @vaibhavbetter @FOXOclub Sure.. my team @iam_supratik999 will coordinate

@skipiit @vaibhavbetter @FOXOclub got it.. booking for wife.

I just upgraded my annual blood test with FOXO Primer and got more than I imagined. Because of an autoimmune issue, I’ve had to do more “understanding” of my blood tests than most people, who often look at ranges, underlines, and move on. My annual tests were already more than standard packages, and I had learned to understand inflammation trackers and other markers earlier than I would have liked :) But I knew there was more to know. The challenge was that going beyond standard or expanded tests was either too expensive, too fragmented, or missing the most important layer: someone looking at everything holistically and giving advice that worked across systems. Over the last few years, this has changed globally. Access to extensive biomarker testing has become easier, cheaper, and increasingly paired with medical professionals who know how to correlate results. FOXO brought this to India with FOXO Primer, a comprehensive 200+ biomarker assessment that combines clinical history, system-level analysis, and practical guidance to help you understand how your body is functioning and what you can do to improve it. I was genuinely impressed by the overall experience. We invested in FOXO at the founding stage because we had been clear on this opportunity for a while. But hearing founder Subhendu’s personal journey of “fixing his health”, the journey that led to FOXO, made the mission feel even more real. Nothing drives mission orientation like a personal story, and I could relate to his too. I believe the future of preventive healthcare will be driven by companies like FOXO: helping us understand our health earlier, act sooner, and hopefully avoid many reactive doctor visits later. Think of them as our future “pre-GPs.” Worth exploring if you’ve been curious but sitting on the sidelines: foxo.club/primer

@pravesh @vaibhavbetter @FOXOclub Yes Sir!

@skipiit @vaibhavbetter @FOXOclub available in Delhi ?

@pravesh @vaibhavbetter Hey Pravesh, The PRIMER membership of @FOXOclub is INR 15K but we have only few limited slots for 10K. Book it today: foxo.club/primer

@vaibhavbetter how much are these slots for ?

Applications closing tonight! If you're building in hard tech and frontier sciences in India...rockets, robots, fusion, biotech, semis, physical AI and all that, you should be apply to compete at Curiosity 2026 by @spc_india. ₹1.25 Cr+ in grants, $85k+ in OpenAI credits, live demos and booths for showcase. It's time for the hard-mode builders in India, to have a platform like this. See you there. Apply here southparkcommons.com/curiosity

Completing the Health Spectrum series, Subhendu writes about the Health Trifecta: lifestyle, biomarkers, and symptoms.

@AmazonHelp @amazonIN @amazon Why is the quality of the service going down? The delivery timelines are not getting met and we have to wait for them as if I don’t have any work on weekend. Why can’t I cancel my order now?

@puneetiitm Amazing!

@skipiit Absolutely! Someday I will show you the output. I think you will be amazed.

For two decades, the answer was: delegate. Now, more often than not, the answer is: just do it yourself with AI. I was reviewing our LP deck yesterday and wanted to make a few new slides. Briefing an analyst, waiting, reviewing, revising — would've been 2-3 days. With Claude, 90 minutes. Alone. Team leaders/ Senior leaders who don't update this instinct will get out-shipped by people half their seniority.

@puneetiitm Badhiya hai fir to.. !!

@skipiit It was probably some of the most productive hours.

@atShruti @iampbiswal @ToughSammy DMed you.

@iampbiswal @ToughSammy @skipiit nice!

Made 3 investments this year. Looking for 7 more. What are you building that’s generational? Helped 50+ companies raise $1B+ after we invested. DM or email me.

@arnav_kumar But why?

Ok. We are getting screened.

If you want to feel like a teenager, have a drink with your college friends. If you want to feel geriatric, meet a sports physio.

Health isn't binary. The mistake is trying to fix everything. The move is to find the two or three axes that are actually drifting and spend your effort there. #Under60Seconds #FOXO #Longevity #Healthspan #PrecisionLongevity

@mutant1879 @IamShajanSamuel 👏👏👏👏

What a dumb thing to say! Let me share a fun story. When I was a teenager, a new guy joined our martial art gym - a marathon runner. Marathon runners are generally not good at strength, power, speed, or agility, but his endurance was incredible. He could run for hours without breaking. Yet when he used to spar, he would get out of breath in two minutes. It confused him endlessly, because endurance was supposed to be the one thing he was really good at. Here's why it happened: the endurance he had built was steady-state and aerobic: low-to-moderate effort, same muscles, same rhythm, for hours on end. Sparring is the opposite. It's anaerobic and explosive: short bursts of punches, dodges, and footwork that light up the whole body at near-maximum output. It burns a different fuel system, floods the muscles with lactate and hydrogen ions fast, and demands grip, shoulder endurance, and core bracing that long-distance running never develops. His heart and lungs were elite, but the rest of his fitness was a blank page. It's not hard for one-dimensional fitness to get exposed where multi-dimensionality is required - it happens to bodybuilders and runners alike. The moral of the story is: fitness isn't one thing. Being great at one slice of it doesn't make you great at the rest, and dismissing a sport you've never tried usually says more about your blind spots than about the sport itself.

Marathon is now loosing its sheen, Hyrox is taking over. people are shelling 9000 Rs for 8 km run interspersed with 8 functional workout. 1 km run + 1 workout station * 8. Unlike Marathon, this is relatively easier and everyone can participate. Just need to pay Rs 9000 ..