Tarun Mascarenhas

It always cracks me up when techies who hear about biotech confuse “are doing” with “have convinced someone to give them cash to try to”

Without x-rays, high-powered microscopes, and fancy research equipment... How would you figure out the size of a single molecule? Lord Rayleigh did it way back in 1890, using little more than oil, water, and a pen. His inspiration? Benjamin Franklin. My favorite experiment.🧵

no i dont

@AMAZlNGNATURE Neither do the laws of biology.. (apparently they are not classified in the same genus as goats but are considered a part of the antelope family)

So apparently the laws of physics do not apply to goats

Our first writing fellowship has ended. Starting today, we will release essays written by the fellows at a cadence of one or two each week. First up: A short, personal essay by @StorkDevon, called "When to Give Up." ideasmatter.co/2024/03/14/whe…

@gleech @sudan_shoe Curious about what you mean by emotional health. Also filtered evidence.

@sudan_shoe Get surrounded by truth-seeking people Emotional health (solving insecurity) Writing practice from 16 (1000w/day). Reviews Actual numeracy (6 courses of statistics) Selection effects & filtered evidence 2 courses of philosophical logic Moving past philosophy Not reading the news

Chat, what, specifically, are the things that have upgraded your ability to think? Can we pls make a list ordered by power, with short descriptors rather than millions of words in essays requiring a baseline of superhuman reading comprehension and tenacity to process

Ten interesting things we learned about phages while editing this article for @AsimovPress: 1. You can buy phage therapies over-the-counter at some pharmacies in Georgia. (The country. Not the state.) 2. An oft-cited estimate is that by 2050, at least ten million people could die each year from antibiotic-resistant infections. The same review (from 2016) also predicted that the vast majority of these deaths – up to 90 percent – will occur in Africa and Asia, where antibiotic use is soaring and access to alternatives is poor. Phages could be used to target antibiotic-resistant microbes and kill them. But... 3. No phage-based therapeutic has reached the latter stages of the clinical trial pipeline. 4. There are estimated to be around 100 million different species of phage, and each one is incredibly choosy about which bacteria it will infect. Phages are the "most abundant biological agent on earth." 5. The pioneer of phage therapy, a self-taught, French scientist named Felix d’Herelle, tried to defect to the Soviet Union because they were investing a lot of money on phage therapy research. But his plan was thwarted when Stalin had his Georgian scientific partner executed. He prudently decided to stay in France. 6. New ML tools can predict whether a particular phage will kill a particular microbe with ‘false discovery’ rates of less than 10 percent. 7. It is possible to make entirely synthetic phages using cell-free systems; no bacteria required. The phage DNA is first chemically synthesized, and then a cell's "guts" are used to produce and assemble the protein parts of the bacteriophages. It is akin to a ‘printer, or espresso maker’ for viruses, and the first therapy with a phage synthesized using this method will be tested on a patient within the next few months. 8. A company called @LocusBio can add genes to their phages that not only help to modify their host range, but also confer additional bacteria-killing power. In one trial for a phage mixture targeting E. coli in urinary tract infections, the company achieved a 6-log reduction in bacterial numbers in patients (meaning the number of bacterial cells present has been reduced a million-fold), leading to “100 percent clinical cure” of 31 patients. 9. Bespoke phage products, custom-made for a patients' bacterial infection, would likely cost in the region of $20,000 per treatment. A dose of antibiotics, for context, cost a dollar or two. 10. Combination therapy, using phages and antibiotics together, causes drug-resistant bacteria to focus so much on repelling the phages that they become resensitized to the antibiotics. Interesting! Links to all this, and more, are in the article below. Cheers!

Ted Chiang in the New Yorker: "The tendency to think of A.I. as a magical problem solver is indicative of a desire to avoid the hard work that building a better world requires. That hard work will involve things like addressing wealth inequality and taming capitalism. For technologists, the hardest work of all—the task that they most want to avoid—will be questioning the assumption that more technology is always better, and the belief that they can continue with business as usual and everything will simply work itself out. No one enjoys thinking about their complicity in the injustices of the world, but it is imperative that the people who are building world-shaking technologies engage in this kind of critical self-examination. It’s their willingness to look unflinchingly at their own role in the system that will determine whether A.I. leads to a better world or a worse one." (newyorker.com/contributors/t… ) via Pat Kane, patkane.substack.com/p/omnipedia-37…?

In a talk I attended recently, the speaker said: "Recall, or learn very quickly, that..."

When our most advanced tech was fire, people thought life was like fire, and they were right. Our energy comes from an oxidation reaction. 1/

you're not a "generalist" you're 23

@reangdeba Haha me too :P

Check out our new paper: “Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars” published @NAR_Open. The work of @MindelVladimir and @SagieBr. academic.oup.com/nar/advance-ar…

🔬A look back on the CENTURI Scientific Conference in Cargèse!🧬 Diving deep into the world of "Information Networks in Biological Systems," the talks were nothing short of mind-blowing! 🌟 ➡️More information: centuri-livingsystems.org/2023/11/13/cen… #CargeseConference #BiologicalSystems

📣 You can now apply to the Max Planck School Matter to Life and join us in 2024! 🔥 Whether you apply to the MSc to PhD Direct Track Program or our ten-week paid research internships - we are looking forward to your application! (Deadline: 1 Dec, 2023) mattertolife.maxplanckschools.org/application

We are inviting applications to establish up to two Research Groups for Max Planck Research Group Leaders (W2) in Mathematics for Living Systems @mpicbg @csbdresden. Looking forward to your application and for you to join our team! mpi-cbg.de/fileadmin/UPLO…

Two great talks from Tarun Mascarenhas and Anne-Lena Moor from Zechner lab on information transfer during ⁦@centuri_ls⁩ conference in Cargese. Very interesting. 😊

I have this rant of mine about how every progressive was The Kid Who Reads, acknowledged by admiring librarians and teachers as not being like those other kids, and it's a big part of why progs think education is the answer for everything. Because they were all The Kid Who Reads.

People ask me all the time if I am "pro-Israel" because I am a Jew who has lived in Israel, and my answer is that being "pro-Israel" or being "pro-Palestine" or being a "Zionist" does not properly capture the nuance of thought most people do or should have about this issue. It certainly doesn't capture mine. I have a lot to say. I’ve spent the last 72 hours writing, texting, and talking to Israelis, Jews, Muslims, and Palestinians. Much of my reaction is going to piss off people on "both sides," but I am exhausted and hurting and I do not think there is any way to discuss this situation without being radically honest about my views. So I'm going to try to say what I believe to be true the best I can. Let me start with this: It could have been me. That's a hard thought to shake when watching the videos out of Israel — the concert goers fleeing across an empty expanse, the hostages being paraded through the streets, the people shot in the head at bus stops or in their cars. I went to those parties in the desert, I rubbed shoulders with Israelis and Arabs and Jews and Muslims, I could have easily accepted an invitation to some concert near Sderot and gone without a care, only to be indiscriminately slaughtered. Or, perhaps worse, taken hostage and tortured. I don’t believe Hamas is killing Israelis to liberate themselves, nor do I believe they are doing it to make peace. They're doing this because they represent the devil on the shoulder of every oppressed Palestinian who has lost someone in this conflict. They're doing it because they want vengeance. They are evening the score, and acting on the worst of our human impulses, to respond to blood with blood — an inclination that is easy to give in to after what their people have endured. It should not be hard to understand their logic — it is only hard to accept that humans are capable of being driven to this. Not defending Hamas is a very low bar to clear. Please clear it. It’s not possible to recap the entire 5,000 year history of people fighting over this strip of land in one newsletter. There are plenty of easily accessible places you can learn about it if you want to (and, by the way, many of you should — far too many people speak on this issue with an obscene amount of ignorance, loads of arrogance, and a narrow historical lens focused on the last few decades). But I'll briefly highlight a few things that are important to me. In my opinion, the Jewish people have a legitimate historical claim to the land of Israel. Jews had already been expelled and returned and expelled again a half dozen times before the rise of the Muslim and Arab rule of the Ottoman Empire. Of course it’s messy because we Jews and Arabs and Muslims are all cousins and descendents of the same Canaanites. But Arabs won the land centuries ago the same way Israel and Jews won it in the 20th century: Through conflict and war. The British defeated the Ottoman Empire and then came the Balfour Declaration, which amounted to the British granting the area to the Jewish people, a promise they’d later try to renege on — all before the wars that have defined the region since 1948. That historical moment in the late 1940s was unique. After World War II, with many Arab and Muslim states already in existence, and after six million Jews were slaughtered, the global community felt it was important to grant the Jewish people a homeland. In a more logical or just world that homeland would have been in Europe as a kind of reparation for what the Nazis and others before them had done to the Jews, or perhaps in the Americas — like Alaska — or somewhere else. But the Jews wanted Israel, the British had taken to the Zionist movement, the British had conquered the Ottoman Empire which handed them control of the land, and America and Europe didn’t want the Jews. As a result, we got Israel. The Arab states had already rejected a partitioned Israel repeatedly before World War II and rejected it again after the Holocaust and the end of the war. They did not want to give up even a little bit of their land to a bunch of Jewish interlopers who were granted it all of a sudden by British interlopers who had arrived a hundred years prior. Who could blame them? It had been centuries since Jews lived there in large numbers, and now they wanted to return in waves as secularized Europeans. Many of us would probably react the same way. So, just as humans have done forever, they fought. The many existing Arab states turned against the burgeoning new Jewish state. One side won and one side lost. This is the brutal and broken and violent world we live in, but it is what created the global world order we have now. Are Israelis and British people "colonizers" because of this 20th century history? Sure. But that view flattens thousands of years of history and conflict, and the context of World War I and World War II. I don’t view Israelis and Brits as colonizers any more than the Assyrians or the Babylonians or the Romans or the Mongols or the Egyptians or the Ottomans who all battled over the same strip of land from as early as 800 years before Jesus’s time until now. The Jews who founded Israel just happened to have won the last big battle for it. You can’t speak about this issue in a vacuum. You can't pretend that it wasn't just 60 years ago when Israel was surrounded on all sides by Arab states who wanted to wipe them off the face of the planet. Despite the balance of power shifting this century, that threat is still a reality. And you can't talk about that without remembering the only reason the Jews were in Israel in the first place was that they'd spent the previous centuries fleeing a bunch of Europeans who also wanted to wipe them off the face of the planet. And then Hitler showed up. American partisans have a narrow view of this history, and an Americentric lens that is infuriating to witness. As Lee Fang perfectly put it, "Hamas would absolutely execute the ACAB lefties cheering on horrific violence against Israelis if they lived in Gaza & U.S. right-wingers blindly cheering on Israeli subjugation of Palestinians would rebel twice as violently if Americans were subjected to similar occupation." And yet, many Americans only view modern Israel as the "powerful" one in this dynamic. Which is true — they obviously are. It isn't a fair fight and it hasn't been for decades because Israel's government is rich and resourceful, has the backing of the United States and most of Europe, and has an incredibly powerful military. At the same time, Israeli leadership has made technological and military advancements that have further tipped those scales — all while the Israeli government has helped create a resource-thin open air prison of two million Arabs in Gaza. Conversely, Palestinians are devoid of any real unified leadership, and the Arab world is now divided on the issue of Palestine. Israel is unwilling to give the people in Gaza and the West Bank more than an inch of freedom to live. These are largely the refugees and descendents of the refugees of the 1948 and 1967 wars that Israel won. And you can't keep two million people in the condition that those in the Gaza strip live in and not expect events like this. I'm sorry to say that while the blood on the ground is fresh. The Israelis who were killed in this attack largely have nothing to do with those conditions other than being born at a time when Israel and Jews have the upper hand in this conflict. Some of the victims weren’t even Israeli — they were just tourists. This is why we describe them as “innocent” and why Hamas has only reaffirmed that they are a brutal terror organization with this attack — an organization that I hope is quickly toppled, for the sake of both the Palestinian people and the Israelis. But as someone with a deep love for Israel, with friends in danger and people I know still missing, it breaks my heart to say it but I'm saying it again because it remains perhaps the most salient point of context in a tangled mess full of centuries of context: You cannot keep two million people living in the conditions people in Gaza are living in and expect peace. You can't. And you shouldn’t. Their environment is antithetical to the human condition. Violent rebellion is guaranteed. Guaranteed. As sure as the sun rising. And the cycle of violence seems locked in to self-perpetuate, because both sides see a score to settle: 1) Israel has already responded with a vengeance, and they will continue to. Their desire for violence is not unlike Hamas’s — it’s just as much about blood for blood as any legitimate security measure. Israel will “have every right to respond with force." Toppling Hamas — a group, by the way, Israel erred in supporting — will now be the objective, and civilian death will be seen as necessary collateral damage. But Israel will also do a bunch of things they don't have a right to. They will flatten apartment buildings and kill civilians and children and many in the global community will probably cheer them on while they do it. They have already stopped the flow of water, electricity, and food to two million people, and killed dozens of civilians in their retaliatory bombings. We should never accept this, never lose sight that this horror is being inflicted on human beings. As the group B’Tselem said, “There is no justification for such crimes, whether they are committed as part of a struggle for freedom from oppression or cited as part of a war against terror.” I mourn for the innocents of Palestine just as I do for the innocents in Israel. As of late, many, many more have died on their side than Israel's. And many more Palestinians are likely to die in this spate of violence, too. Unfortunately, most people in the West only pay attention to this story when Hamas or a Palestinian in Gaza or the West Bank commits an act of violence. Palestinian citizens die regularly at the hands of the Israeli military and their plight goes largely unnoticed until they respond with violence of their own. Israel had already killed an estimated 250 Palestinians, including 47 children, this year alone. And that is just in the West Bank. 2) Every single time Israel kills someone in the name of self-defense they create a handful of new radicalized extremists who will feel justified in wanting to take an Israeli life in retribution sometime in the future. Half of Gaza’s two million people are under the age of 19 — they know little besides Hamas rule (since 2006), Israeli occupation, blockades, and rockets falling from the sky. The suffering of these innocent children born into this reality is incomprehensible to me. They will suffer more now because of Hamas’s actions and Israel’s response, all through no fault of their own. There is no way out of this pattern until one side exercises restraint or leaders on both sides find a new solution. Israelis will tell you that if Palestinians put their guns down then the war would end, but if Israel put their guns down they'd be wiped off the planet. I don't have a crystal ball and can’t tell you what is true. But what I am certain of is that every time Israel kills more innocents they engender more rage and hatred and recruit more Palestinians and Arabs to the cause against them. There is no disputing this. So, why did this happen now? I'm not sure how to answer that question except to say it was bound to happen eventually. It was a massive policy and intelligence failure and Netanyahu should pay the price politically — he is a failed leader. Iran probably helped organize the attack and the money freed up by the Biden administration's prisoner swap probably didn't help the situation, either. Israel's increasingly extremist government and settlers provoking Palestinians certainly didn't help. Nor has going to the Al-Aqsa mosque and desecrating it. Nor do blockades and bombings and indiscriminate subjugation of a whole people. Nor does refusing to talk to non-terrorist leaders in Palestine. Nor does illegally continuing to expand and steal what is left of Palestinian land, as many Jews and Israelis have been doing in the 21st century despite cries from the global community to stop. A violent response was predictable — in fact, plenty of people did predict it. Israel is forever stuffing these people into tinier and tinier boxes with fewer and fewer resources. But if you want to blame Israeli leaders for continuing to expand and settle land that does not belong to them (as I do), then you should also spare some blame for Palestinian leaders for repeatedly not accepting a partitioned Israel during the 20th century that could have led to peace (as I do). Please also remember this: Hamas is still an extremist group. The Palestinian people do not have a government or leaders who legitimately represent their interests, and it sure as hell isn't Hamas. Will some Palestinians cheer and clap at the dead, or spit on them as they are paraded through Gaza? Yes they will. And they have. Many will also mourn because they loathe Hamas and know this will only make things worse. This is no different than how some Americans cheer at the dead in every single war we've ever fought. It's no different than the Israelis who set up lawn chairs to watch their government bomb Palestine and cheer them on, too. This doesn't mean Palestinians or Israelis or Americans are evil — it means some of them are giving in to their violent impulses, and their zealous feelings of righteous vengeance. Solutions, you ask? I can’t say I have any. If you came here for that, I’m sorry. The two-state solution looks dead to me. A three-state solution makes some sense but feels out of the view of all the people who matter and could make it happen. I wish a one-state solution felt realistic — a world of Israelis and Arabs and Muslims and Jews living side by side with equal rights, fully integrated and defused of their hate, is a version of Israel that I would adore. But it seems less and less realistic with every new act of violence. Am I pro-Israel or pro-Palestine? I have no idea. I'm pro-not-killing-civilians. I'm pro-not-trapping-millions-of-people-in-open-air-prisons. I'm pro-not-shooting-grandmas-in-the-back-of-the-head. I'm pro-not-flattening-apartment-complexes. I'm pro-not-raping-women-and-taking-hostages. I'm pro-not-unjustly-imprisoning-people-without-due-process. I'm pro-freedom and pro-peace and pro- all the things we never see in this conflict anymore. Whatever this is, I want none of it.