Thad Wester
2.9K posts
@peter_mantas @johnarnold holy. so dang unusual to see something actually happen. serious implications $clpt $qure
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Well, well, well.
Both nodes of the @johnarnold network at CBER are now simultaneously being replaced.
Prasad = gone; Szarama = gone.
RFK and Makary next.
This ain’t a game, dawg.
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@MartinShkreli @DrMakaryFDA @johnarnold "It is difficult to get a man to understand something, when his salary depends on his not understanding it" $qure $clpt
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its clear @DrMakaryFDA is in @johnarnold pocket
both have to go, Makary first
Dirk Haussecker@RNAiAnalyst
FDA commish @DrMakaryFDA has been using exact language of @johnarnold as can be seen in this thread during recent $srpt Elevidys turmoil. When viewed through lens of Arnold being the moneyed interest behind Makary, Prasad and new hires, everything makes sense. Makary and Prasad have been mere low-level henchmen.
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@wfhtrader1 @mike98572986 @DarrenEstes The cost argument is nuanced. Long term, full time care is very expensive.
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@tbwester @mike98572986 @DarrenEstes I’m making significant concessions to the FDA. While costs technically shouldn’t factor in, Prasad has suggested they should. And if cost-benefit is considered, the approval is further hard to justify.
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Please explain. Is Arnold against rare disease drugs?
mike@mike98572986
$qure $clpt this is pretty deep, time for Marky Mark, and Scientist Andy to be fired. Marky Mark and Prasad have been paid off to say f u to rare disease patients. This is absolutely sickening and horrendous. Should be a huge investigation. Should be front page news. Marky Mark has got to go. Basically, Prasad’s whole philosophy comes from Arnold Ventures due to being paid off 2 million dollars. Anyone that has said Prasad is a man of integrity and science should be ashamed of themselves. If anyone ever says anything about Prasad being a man of integrity, you don’t need to say a word, just refer to that post. He is bought and paid for, the lowest of the low on the scumbag scale. They don’t feel a rare disease life is worth saving, all rare disease organizations should be showing up to the fda door and demanding Makary to step down. He is cooked. @RepAuchincloss @SenRonJohnson @SenRickScott @SenGillibrand @WhiteHouse @FrankLuntz @SusieWiles @BeckyQuick @HDSA @HDBuzzFeed @Help4HDI @adamfeuerstein
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@wfhtrader1 @mike98572986 @DarrenEstes Isn’t the FDA tasked with NOT addressing cost in their approval process?
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@tbwester @mike98572986 @DarrenEstes That wasn't the question. I agree that FDA should stay impartial but the stance that they're taking, whether it's influenced or not, doesnt seem like a bad stance. If you disagree from a cost benefit standpoint, I urge you to show me the math that AMT-130's pros outweigh the cons
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@wfhtrader1 @mike98572986 @DarrenEstes Yes, very good to have a well funded, ideological third party intervening in the governments drug approval process, what could go wrong?!? $clpt $qure
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@mike98572986 @DarrenEstes Just playing the devil's advocate here. What is wrong with that philosophy, if not shrewd?
To give you an extreme example, would you be in favor of the central bank printing $10T to save one life?
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@mike98572986 @SRPT true. its just so weird that Marty acts like he is championing this who new framework, and behind closed doors it couldn't be further from the truth.
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$qure $clpt $rgnx @srpt
Retweet the heck out of this thread. Lays out the entire crime scene. This is like a public murder of rare disease patients
Be sure to @ the proper people. This needs immediate attention
Adam, this story has stat news all over it, Ron Johnson and other Congress members need to be aware fully of what has happened here.
@RepAuchincloss
@SenRonJohnson @SenRickScott @SenGillibrand @WhiteHouse @FrankLuntz @SusieWiles @BeckyQuick @HDSA @HDBuzzFeed @Help4HDI @adamfeuerstein @MartinShkreli @laurencurehd @JRenz0418 @DesertDweller93
CP2@LuckyPenguin10
Ok, this is all snapping into focus. And candidly, the picture that's emerging is far more interconnected than anyone assumed re: what's happening to $QURE AMT-130 and the broader rare disease ecosystem. This also seems to explain Vinay Prasad's abrupt (second) resignation. If all this adds up — there's a specific law within the Standards of Ethical Conduct that becomes very relevant: 5 CFR § 2635.502, "The Impartiality Rule." To be clear, this is not an accusation — simply following the paper trail. Everything here is drawn from public records, sources at the bottom. Ok, let's start...
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@mike98572986 @DarrenEstes and even weirder is that Marty runs the media show 24/7 saying the EXACT opposite.
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$qure $clpt $rgnx $sldb
If you read his papers and thoughts he basically says a rare disease life isn’t worth saving due to the cost. The entire premise of his thoughts is that it hurts the overall system and therefore should just let them die. That is the entire thesis of Arnold Ventures, Prasad has been paid 4 million dollars from them and this is now his world view, since he has been paid off by them. Makary has also been paid off and now you have some others that have been paid off in the FDA. Basically the whole thesis is that they believe the costs of the rare disease drugs are too high and takes resources away from the overall system and therefore their lives are not worth it. Basically in whole, saying, just let them die, they are a waste of our money and time.
@RepAuchincloss
@SenRonJohnson @SenRickScott @SenGillibrand @WhiteHouse @FrankLuntz @SusieWiles @BeckyQuick @HDSA @HDBuzzFeed @Help4HDI @adamfeuerstein @laurencurehd
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@docrodwong "trump administration represented the opposite"
good point. Marty continues yap on about flexibility and then does the opposite.
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this is the first major mention i've seen of arnold venture's influence on this fda. arnold is said to be have been a major backer of prasad's research (i don't have proof of this, have just been told many times), and as wsj notes, szarama worked at arnold before prasad brought her in. most aren't aware arnold ventures was the major backer of ICER, the group that defines the value of medicines for the UK (which is set at a cap of roughly 30k pounds per human life year). it is also the reason the UK has dropped below basically all other developed countries when it comes to access to rare disease medicines. in short, arnold doesn't believe rare disease medicines are worth it, and it's natural to conclude prasad and others were bringing that philosophy to fda. now it's fine to have that view as a society (as the UK chooses to), but the trump administration represented the opposite, which is to accelerate access to rare disease medicines.
wsj.com/opinion/one-ex…
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@mike98572986 @DrMakaryFDA Feels odd. Why do they keep speaking one way and doing another
GIF
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$qure $clpt If you truly gave 2 shits about real world evidence all you would need to do is talk to the patients and the neurologists that are treating them yet your boy Prasad wouldn’t even show up to the Type A meeting to hear them out. Victor Sung who has seen more patients in this trial than any other neurologist was there and you guys clearly didn’t hear him out when the main guy that has an issue with it didn’t even bother to show up.Give me a freaking break man, how can you honestly talk like this. Complete and utter lies. You don’t value real world evidence at all if these are your actions. Do better Marty. You can still fix this catastrophic mistake and be a hero.
@RepAuchincloss
@SenRonJohnson @SenRickScott @SenGillibrand @WhiteHouse @FrankLuntz @SusieWiles @BeckyQuick @HDSA @HDBuzzFeed @Help4HDI @adamfeuerstein
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@sweatystartup kind of an off part of the season. too late to ski and still cold
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Just rented a $3 million house in the Smokey Mountains for $400 a night.
6,000 sf. 7 bedrooms 8 baths.
The market must be getting absolutely crushed.
Is visitor traffic down that much? Too many Airbnbs?
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This is a good synopsis of why VP was pushed out. Too bad it is behind a paywall.
But high-level summary of reasons:
1) Created a toxic work environment at the FDA and personally threatening employees
2) Ignored all FDA guidances, rules, and norms. He thinks his personal opinion should be THE law - it is not and it is illegal!
3) Vaccine thing - doing RFK Jr.'s bidding
4) Doing opposite of what Makary said FDA is doing - making it easier for sponsors to develop drugs for rare diseases.
5) Being a regulator is very different than being an academic podcaster.
Matthew Herper@matthewherper
5 lessons from Vinay Prasad’s turbulent tenure at the FDA Prasad brought his convictions to the agency — and reaped chaos. My thoughts on an eventful week for one of the most outspoken people in medicine. statnews.com/2026/03/08/vin…
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@EdPiotrowski T-storm in Florence with a little bit of pea sized hail
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1:30 P.M. SUNDAY WEATHER UPDATE
With plenty of warm, somewhat humid air in place and a weak cold front approaching, scattered showers and a few thunderstorms will develop late this afternoon and evening. The best chance for a storm will be between 5 and 10 p.m. One or two storms could produce strong wind and quarter-size hail, but the tornado risk is zero. Keep in mind that most of you won’t see severe weather, and many won’t see rain at all. I’ll keep you posted.
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@Macro_First @LabbRadar I agree it seems like there’s a swarm of AI posters applauding VP and negative on $qure
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@LabbRadar She's writing a load of codswallop using AI. Clearly not a real opinion.
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x.com/labbradar/stat…
Jessica, kindly please read my thread where I’ve detailed factual and categorical mistakes in Anish’s article. He omits a lot of stuff out that hurts his position. Intentionally misleading $QURE
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Not only did the journalist decide to reveal identifying information, someone higher up then ok’d that story not being paywalled to make sure as wide an audience would know.
Neeraja Deshpande@neerajadeshp
@anish_koka @emilyakopp @AlexBerenson It was an absolute breach of ethics, absolutely shameful.
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Mortimer, we’re back $QURE $CLPT
Michael Bigger@biggercapital
After $QURE debacle I bought a new home in Las Vegas
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$qure when is someone from the media going to “anonymously” leak the name of the Sr FDA official?
Asking for a friend
Pearl Freier@PearlF
The FDA held a media call with reporters from Bloomberg, STAT, NY Times, WSJ, Politico & other media organizations all on the same call—but insisted on anonymity for the name of the senior FDA official. This is what HHS calls "radical transparency" with the public & patients:
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Doesn't this sound like none other than @VPrasadMDMPH who is attacking @uniQure_NV $QURE AMT130 trial? Thanks Adam for taking down the paywall so all can read and share this story. Everyone needs to make this go viral so VP and MM are out of jobs ASAP.
statnews.com/2026/03/06/fda…
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