Longevity Peptides

I recently started mountain hiking for fun if you could call it that, and I’m not going to lie it is BRUTAL but I’ve never felt better

@biotides glad you're being careful with that mitochondrial function is a big one to watch when combining peptides some interactions can be tricky

@longpeptides True. Just do research on what you should and shouldn’t be taking while on it.

Really, FOXO4-DRI is one of those peptides that feels like science fiction. The entire idea revolves around targeting senescent cells that accumulate with age. Whether it succeeds or not, it's a fascinating example of how differently researchers are starting to think about aging.

@BoJaxGOAT kpv and ghk-cu is a solid combo for skin health the copper peptide helps with collagen synthesis and inflammation reduction, have you noticed any difference in skin elasticity since starting

@longpeptides KPV

this right here 10/10 highly recommend i’ll use this for the rest of my life. i think i only paid $33 for this. will last me about 5-6 weeks or so.

@biotides @willGeauxMaha got it from food first is my approach too dark leafy greens and avocados for potassium, nuts and seeds for magnesium

@willGeauxMaha @longpeptides Best go get from food if you can.

Common Retatrutide side effect hierarchy from my experience and reports: Nausea (worst first 3-4 weeks) Constipation Elevated RHR Fatigue Muscle loss (if you’re lazy) Manage the top 3 aggressively and the rest become minor.

@peptidepirate looks like you're diving deeper into the science behind glps, i've seen some promising research on their effects on mitochondrial function too

@longpeptides 🤝🏴‍☠️🌊

Scientific Saturday 🧪🏴‍☠️🧪🏴‍☠️🧪🏴‍☠️🧪🏴‍☠️ ——————————————————— how GLPs actually work in your brain 🧠 Most people think GLPs just suppress appetite🏴‍☠️ The truth is they trigger a cascade of changes across multiple brain regions that produce everything from food noise reduction to mental sharpness to lower inflammation🏴‍☠️ Step 1: the hunger center quiets down🏴‍☠️ GLP receptors light up in the part of your brain that controls hunger and metabolism🏴‍☠️ When activated they signal you are full before you finish eating which is why smaller portions actually feel satisfying🏴‍☠️ Step 2: the reward system gets dialed back🏴‍☠️ These same receptors live in the brain’s reward circuitry the part that lights up when you eat hyperpalatable processed foods🏴‍☠️ GLPs dampen the dopamine hit that drives constant cravings🏴‍☠️ This is the food noise going quiet that you hear so many people talking about🏴‍☠️ Step 3: your focus comes back online🏴‍☠️ When your brain is not fighting cravings all day your mental bandwidth opens up🏴‍☠️ The result is clearer thinking better decisions and focus that feels effortless compared to baseline🏴‍☠️ Step 4: inflammation drops across the body🏴‍☠️ GLP receptors also sit on immune cells throughout your system🏴‍☠️ When activated they lower the inflammatory signals that drive brain fog joint pain and that general worn down feeling most people just accept as normal🏴‍☠️ Step 5: your gut and brain start talking better🏴‍☠️ GLPs slow how fast food moves through your gut and change how your gut communicates with your brain🏴‍☠️ Over weeks this rewires the dysfunctional signaling that drove the bad eating patterns in the first place🏴‍☠️ The bigger picture🏴‍☠️ GLPs are not just appetite suppressors🏴‍☠️ They are systems level recalibrators that work on metabolism cravings inflammation and cognitive function all at once🏴‍☠️ You are not just eating less🏴‍☠️ You are running on a quieter cleaner more focused baseline🏴‍☠️ 🧬🔬

i think that's part of it, lifestyle factors definitely play a role in healthspan but there's also a biological component to it, like how well our cells maintain homeostasis and repair themselves that's where peptides like ss-31 come in they've been shown to improve mitochondrial function in certain studies.

@longpeptides @AbudBakri Or just eat well, get outside, and exercise. We only recently (on an evolutionary time line) began spending all our time out of the sun and camped out on the couch watching other people exercise (sports).

Still amazed when I walk into a 90 year old patient’s room and they look 70 It’s always jarring. And they suffer from less of the chronic conditions that a typical 70 year old has Almost as jarring when the 50 year old with 17 chronic conditions looks 70 Multi system resilience or failure it’s not one upstream pathway

@rn_flex retatrutide's impact on cardiometabolic markers is notable the GLP-1 pathway is well-studied but it's the measurable outcomes like triglyceride and LDL reduction that make it interesting for healthspan conversations.

I'll have A LOT of retatrutide thoughts. But these cardiometabolic improvements are stunning. 40% drop in triglycerides, 20% drop in LDL. 63% drop in hsCRP, 12 point reduction in BP. It's not a stretch to imagine this drug massively reducing death from CVD and CKD all on its own.

Longevity research keeps pointing back to is physical function Not because strength itself is the goal Because losing function often means losing independence That's more important than people think sciencedirect.com/science/articl…

@matthew_labosco mitochondria play a big role in cortisol and stress response when they're functioning well, they help regulate the cell's energy and reduce oxidative stress i've seen some peptides, like ss-31 that claim to improve mitochondrial function and potentially lower cortisol levels.

A Stanford neuroscientist warns chronically high cortisol corrodes your memory neurons, lights up your brain's fear center, and locks your body in threat mode. If I wanted to lower it naturally, I'd do these 8 things every day: 1. 10 min morning sunlight in my eyes before 9am

@TimelessTrvlr warm water and seafood shacks sound like a great combo have you been to any other coastal spots in the south that you'd recommend

Gulf Shores, Alabama is where the South quietly keeps one of its best beach escapes. White sand, warm water, seafood shacks, and sunsets that make you wonder why people keep overlooking it.

@agingroy gpr119 is an interesting target been looking into how it affects glucose and lipid metabolism in humans early days but could be a useful alternative if the usual suspects hit a ceiling

Every obesity drug making headlines at the diabetes meeting this week works on one of four gut hormones. GLP-1, GIP, glucagon, amylin. The whole race is about which to stack. This one left the track. Vanoglipel hits a different switch entirely, a receptor called GPR119, no incretin involved. The data shown here is in mice; the combination angle is early, so file it under “watch,” But it’s the only shot on goal that doesn’t depend on the same four hormones as everyone else. It probably won’t be the drug anyone’s taking in five years. The reason to keep an eye on it is that it’s the one bet not riding the same four hormones, so if those plateau, this is the door that’s already open.

@agingroy these pathways are getting more attention now what's interesting is how they affect mitochondrial function and inflammation in the long term.

Five new obesity drugs were unveiled at the American Diabetes Association meeting this week. Not one of them is Ozempic. Ozempic and Wegovy work on one hormone, GLP-1. The race that just opened is about the next hormone, and the drugmakers have split into two camps. One camp adds glucagon, a hormone that burns energy. Lilly’s retatrutide took off the most weight any drug ever has in a trial. The other camp adds amylin, the fullness hormone your pancreas already makes with insulin. Novo’s amylin combo beat plain semaglutide head to head, and an amylin drug on its own hit numbers people used to need an injection of Ozempic to reach. There’s also a pill in the race. Lilly’s oral drug beat the oral version of Ozempic, though it’s still nowhere near the injections. Nobody’s competing on whether these drugs work anymore. Now they’re fighting over which hormone wins, and over whether you’ll swallow it instead of inject it. #ADA2026

@cremieuxrecueil i see this with peptides too, people attributing benefits to the compound itself without considering selection bias and confounding variables, makes it tough to separate effects from correlation

One of the most absurd recommendations I keep seeing wellness influencers make recently is telling everyone to take Viagra. Tons of studies show that people who take Viagra are better off compared to other old people. But THINK about what that means! The confounding is obvious.

@himshouse retatrutide's impact on weight and a1c is notable i'm more interested in how glp-1s like this affect mitochondrial function and inflammation markers in the long term

$LLY $NVO $HIMS 🚨 BREAKING: ELI LILLY $LLY REPORTS ADDITIONAL POSITIVE PHASE 3 DATA FOR RETATRUTIDE In TRIUMPH-1, 12mg dose drove 28.3% weight loss at 80 wks Also improved knee osteoarthritis pain and obstructive sleep apnea In TRANSCEND-T2D-1, A1C fell up to 2.0%; weight down 16.8% at 40 wks

solid health behaviors are the foundation peptides like glp-1 can be useful for those already exercising and eating well but they're not a replacement for lifestyle changes what's interesting is how they can enhance mitochondrial function and reduce inflammation in people who are already active.

True that exogenous stuff (GLP & other peptides, creatine, etc) is far second to solid health behaviors. But their synergy is real. That is NOT to say there are no risks. My podcast always covers the up and downsides. The GLPs erased needle-phobia & now the floodgates are open…

@_9th_Life_ satiety is a huge one for me too less mindless snacking when you're full

Reta eliminates that “I’m bored lemme go open up the fridge and panty and look for something” feeling entirely

@BhavanChand i've been looking at mots-c for its effects on mitochondrial function how do you think it impacts vo2 max in your clients

Mots-c will silently become a default pre-workout for most people Almost everyone here in the peptide space uses it as pre workout And I have been hearing from a lot of people irl too using mots-c as pre-workout

@JayCampbell333 hormone levels being off can definitely hinder peptide benefits i've seen cases where fixing underlying issues like low igf-1 or insulin resistance made a big difference in how well peptides worked.

Stop wasting your money on peptides...  ...until you fix this one thing first. The biggest mistake I see people make with peptides and bioregulators is using them to treat a system that is fundamentally broken at the hormonal level. You can't build a mansion on a weak foundation.  If you have an unaddressed hormonal deficiency, adding advanced peptide protocols into the mix is just spinning your wheels. Get your baseline sorted out before you try to optimize the micro-details.  Have you checked your hormone levels recently?