Kevin A VanDriel

@sowmay_jain @laukiantonson You did have an idea it was possible because you built it with the idea it was possible

i got my whole genome sequenced two years ago and forgot about it. last week i told my ai agent (@laukiantonson) to dig up my DNA files • it dug up a two-year-old email • found the download link • pulled down 67 gigabytes of raw DNA. • rented a 32-core, 64GB machine for a few hours — total cost: $5 • aligned 21 million long reads to the human reference genome — 99.83% mapped • called 5.8 million genetic variants using a two-pass neural network • phased every variant — separated maternal vs paternal inheritance • annotated all 5.8M variants against ClinVar, PharmGKB, and gnomAD • corrected for population-specific bias in the medical literature • health risk map across 39 conditions flagged in every body system • drug compatibility guide for 141 medications color-coded by genome response • nutrient metabolism - 71 variants affecting absorption of vitamins, minerals, iron • traits, ancestry going back 40,000 years, neanderthal DNA breakdown $5 in compute. 8 hours. no bioinformatician. no doctor. just one instruction. we've genuinely reached a point where an ai agent can take your raw genome and hand you back a full personal health profile in a single shot. i had no idea this was even possible.

@thesightsmith @tomfgoodwin

the overwhelming abundance. and shortly thereafter the indolence, ingratitude, depravity, resentment, immaturity, infertility. the universal lack of reverence and respect. the profound ugliness of public spaces. the obvious poor health of the people. the depression and nihilism. they would be very confused, because they would also see we have so much they could never have imagined.

If you brought someone into 2025 from 1825. What would be the most amazing things they'd notice, that we don't tend to think about .

@CollinRugg That name is pretty fuckin’ ninja.

NEW: The CIA used a secret tool called "Ghost Murmur" that uses AI to find heartbeats to rescue the U.S. airman who was stranded in Iran, according to the New York Post. The secret technology was allegedly used for the first time in the field, according to the Post. "The secret technology uses long-range quantum magnetometry to find the electromagnetic fingerprint of a human heartbeat and pairs the data with artificial intelligence software to isolate the signature from background noise," the Post reported. "It’s like hearing a voice in a stadium, except the stadium is a thousand square miles of desert," the source said. "In the right conditions, if your heart is beating, we will find you." "The name is deliberate. ‘Murmur’ is a clinical term for a heart rhythm. ‘Ghost’ refers to finding someone who, for all practical purposes, has disappeared..." "Advances in a field known as quantum magnetometry, specifically sensors built around microscopic defects in synthetic diamonds, have apparently made it possible to detect these signals at dramatically greater distances." CIA Director John Ratcliffe appeared to hint at this technology on Monday, saying the CIA possessed "unique capabilities" but said he couldn't "tell you everything that you want to know." President Trump also revealed during the press conference that the CIA spotted the officer from about "40 miles away." Insane.

@shawmakesmagic I'd say culture will have a lot of influence here.

I just realized One of the reasons the west dominated in technology is that our character set is typewriter friendly So we could fit all glyphs into a small space, where eastern languages wouldn’t work, they needed whole new script just for computers But now we’re in the age of AI, and eastern scripts can represent full words in a single token, way more efficient and cheaper The pendulum swings back Just saying

@hiarun02 Ah yes the cynical pessimist

> Every idea feels taken. > Every API already exists. > Every SaaS has 12 competitors. So what do we build now?

@itsdardan @boxmining I hope it's made into a movie. The adaptations of Andy Weir's novels are proof it can be done well, and this book should receive that treatment.

@noxestyle @boxmining I genuinely glad I could do that for a man of honor like yourself good sir Kevin

anyone running this? Just started the installation.

@Ken_CPB @bryan_johnson @maximumpain333 Not sure if Ronnie does so well these days.

@bryan_johnson @maximumpain333 Tell that to 4 time Olympia champion Jay Cutler who slept in 2 4-hour shifts for 20 years. He would get up after 4 hours, eat a meal, then go back to sleep after an hour. 8-time Olympia winner Ronnie Coleman did the same.

The most dangerous lie in human history isn’t about food. It isn’t about medicine. It is about sleep. For 200,000 years, humans did not sleep 8 hours. That number was invented in 1938 by a mattress company called Simmons Beautyrest. Before that campaign, the average human slept in two shifts. Historians call it “Biphasic Sleep.” You would sleep for 4 hours, wake up for 2, then sleep for another 4. During that 2-hour window, people would pray, have s*x, write, think, and connect with their families. Some of the greatest works in human history were created in that sacred middle window. Shakespeare wrote most of his plays between 1AM and 3AM during his second wake period. Mozart composed entire symphonies in what he called “The God Hours.” Then the Industrial Revolution needed workers on a fixed schedule. You cannot run a factory on biphasic sleep. So they hired a psychologist named Dr. Nathaniel Kleitman to “prove” that 8 consecutive hours was the biological standard. He faked the studies. He was funded entirely by the mattress industry. And the medical establishment adopted his research without question because it aligned with the factory model. They turned the most creative 2 hours of human consciousness into a “sleep disorder.” They called it “Insomnia.” They medicated it. They gaslight an entire generation that 8 hours of continuous sleep was healthy. They pathologized the exact window of consciousness that produced some of the greatest art, music, and literature in human history. You are not an insomniac. You are experiencing the most natural form of human consciousness. And a mattress company convinced you it was a disease. Stop medicating your genius. Wake up at 2AM. Write the thing. The “God Hours” are calling. ✨🙌🏾💫 © Andre Gonzalves

@gr8tful88 @WallStreetApes @Thevictoria76 Has to be rage bait

Imagine the impact of a 50% wealth tax on the top 0.1%. 💸 By redirecting those resources, we could: • Fully fund universal healthcare and education 🏥📚 • Rebuild crumbling infrastructure and green energy grids 🏗️🌱 • Eliminate the deficit while lowering the tax burden on the working class 📉 It’s not just about math; it’s about investing in a more stable, equitable future for everyone. 🌍✨ #WealthTax #EconomicJustice #Equality

Jamie Dimon, CEO of JPMorgan Chase, says that US Government raising taxes doesn’t do anything to help the average American He says raising taxes does nothing because Congress just launders the money to their friends, special interest groups and “17,000 lobbying groups” “I don't know anyone, and you guys in the room, you might be Democrats, Republicans who thinks that sending another trillion dollars to Washington D.C will actually improve anything. So when you say raise taxes, if you said raise taxes and directly give it to the people who need it, do it. That does not happen. It goes to all these interest groups, and they give it to their friends and all that.” “Which is why the people are considered a swamp. It's kind of a swamp, the 17,000 lobbying groups. But bank companies are guilty too. They're just fighting for their one self-interest as opposed to what's good for my country”

@guybedo @om_patel5 Was wondering that myself

@om_patel5 that's fun but totally useless. 10k tokens used for the code, 100 tokens for the final message saying the code is written. With your hack, we're down to 10025 instead of 10100 ...

I taught Claude to talk like a caveman to use 75% less tokens. normal claude: ~180 tokens for a web search task caveman claude: ~45 tokens for the same task "I executed the web search tool" = 8 tokens caveman version: "Tool work" = 2 tokens every single grunt swap saves 6-10 tokens. across a FULL task that's 50-100 tokens saved why does it work? caveman claude doesn't explain itself. it does its task first. gives the result. then stops. no "I'd be happy to help you with that." no "Let me search the web for you" no more unnecessary filler words "result. done. me stop." 50-75% burn reduction with usage limits getting tighter every week this might be the most practical hack out there right now

@Approach52220 @iAnonPatriot Not a very intelligent take, yo

@iAnonPatriot they will probably cost close to,over a or several million just to own,so uhm...... NOPE!

Be honest, Are yall buying one of these if it does chores around the house..??

@jumperz Not a very intelligent take, yo.

let me get this straight: >you sell a model >someone builds real infrastructure on it >it works so well you can’t handle the load >so you email your entire user base blaming the builder >then offer him the door you didn’t just lose a power user, you just told every dev watching that if they build too hard on claude they’re getting kicked out… aws would never hit up their biggest customer like “hey bro you’re using too much aws lol” but anthropic just did and threw in a coupon..

@Bencera Yeah but you won't look/sound important. And you won't meet other people who look/sound important.

Unpopular founder take: I fly economy. Business class is paying 10x to fall asleep slightly faster. The ROI is terrible and it’s my job to be good at ROI.

@rochalucasdev @javilopen Dumb is not the right word. I don’t know how to code in Visual Basic 6 anymore. Not because I’m dumb. Because I don’t need to.

@javilopen I barely do any analog coding anymore and I feel myself getting dumber by the day. Paradoxically, it's very difficult to go back to the old ways

Serious question: Is there any programmer left in the room still coding the traditional way, character by character, without using AI? If so, why? Explain your reasoning.

@FakePsyho @th3betterself what is "twitter"?

Choosing video format was a poor decision on my side. Each post has a human/robot emoji next to it (below is the fragment of the same post but with autocollapsing enabled) I won't be making this public as I'm sure twitter/X would not be happy about this. Obviously this can be done for any browser.

I got tired of engagement-farming AI reply bots, and a few hours later I had a firefox extension that correctly tags (and hides/collapses if enabled) about 90% of them. Turns out you can detect most of these accounts just by analyzing their posting patterns. Take their last 200 tweets and find the maximum number of reply tweets within any 5-minute window. If it's 4 or higher, it's an automated reply account. I manually tagged 100 suspicious accounts and 50 terminally online accounts. This single if matched 86/100 of sus accounts and none of the terminally online ones. I've been running this for a few days now and I'm still surprised by the accuracy. I'm pretty sure you can detect almost all of this AI slop without even looking at the content of tweets. I manually checked "false positives" I got and all of them were either: (a) accounts spamming gifs/single words/emoji replies, which is more or less the same behavior just without AI (b) accounts that used AI replies in the past. tl;dr: fixing majority of the current slop apocalypse requires a 0.1x engineer and a minimal effort

@SlumRNA_Dog re: re: re: ha ha!

I really don’t get the point of two factor authentication on my utility bill website like what the fuck are they gonna do? Hack in and pay my bill for me?

@3hzhz3 @rohit4verse @bcherny

@rohit4verse @bcherny Guys this is literal BS. I made claudecodetools.dev scraping and rating every single AI resource out there and then making personalized toolkit for your specific needs and projects. It’s free, I use it myself and it’s public, i gain nothing from it, but do not listen to BS.

I thought I was a Claude Code power user. Then the creator of Claude Code(@bcherny) dropped this thread and I realized I've been using maybe 30% of the tool. >Scheduled automation loops. >Hooks into the agent lifecycle. >Git worktree parallelism. >Fan-out across hundreds of agents at once. >Coding by voice. This thread is mandatory reading if you're building with it.

@MarcusHouse @ThePrimalDino I stand with Marcus House.

I've been running Artemis updates basically every video lately David. Last video - 1800 words 2nd last - 400 words 3rd last - 200 words (quick mention of repairs) 4th last - 1100 words 5th last - 700 words 6th last - 650 words I don't make dedicated videos about any individual thing because there is so much great stuff to cover each week. That is my style and I'm sticking to it. Perhaps cast that shame elsewhere huh?

Real talk time guys. I’m going to preface this by saying I too am guilty of this, just as Tim and the rest of the spaceflight influencers are, as I have only published on Artemis II video that I had planned thus far. And so I include myself in this group, but the reason nobody is aware of this mission is because we haven’t been making ANY content about this mission. AT ALL. Tim and others such as WAI and Marcus house have no videos about Artemis II on their channels. Scott has one KSP video about it (as do I) and I’ve seen a few others with one or two videos but that’s IT. Spaceflight influencers have enormously FAILED the everyday person. We haven’t properly produced the content that would otherwise have gotten millions of people talking about this event. It’s honestly shameful. We’ve been asking for decades “when will we return to the Moon” and then when it finally happened, we remained silent about it. It’s a sad state of affairs, and the next time we go to the Moon, it MUST be different.

@itsdardan @boxmining That was a good read. I’m enlightened and, frankly, humbled.

@noxestyle @boxmining I’m glad you think so. I have a book for you to read about it if you want Here you go 📖 Lemme know how the story is for you once you’re done reading it

@itsdardan @boxmining Cool story bro

@boxmining I just got building my own platform that I’ve had live for 3 hours now. No longer using anything that anyone else built, working on getting a GitHub repo ready to release after making sure it’s as smooth and polished as it can be

@CrossoverYao @davidmarcus Written by AI

It's wild that every time you run a Codex code review from Claude Code, it finds critical issues. Not 95% of the times, 100%.