Antoine

@not_oh57110 @boomerx420 @JoshuaMFrench @X @elonmusk @PRAGMATAgame @CapcomUSA_ A work DAY? Buddy who wants to work a whole day at a time? After the communist revolution we'll work 45min max

@boomerx420 @JoshuaMFrench @X @elonmusk @PRAGMATAgame @CapcomUSA_ 2 days??? That’s insane. The work week should really be a single work day.

Okay, so the idea that #PRAGMATA was developed to awaken paternal instincts and pull Japan back from the brink of declining birthrates seems absurd… until you combine that with @X and @elonmusk deleting communication barriers between Japan and America, then it makes total sense.

@BakeryBab @SwannMarcus89 Why are they being so hot and cold with this poor man

@kaskarn @SwannMarcus89 Imagine having to go and lie down to think about Associated Press for a li'l while 😭

Have you considered just not cheating and spending time with your kids instead?

@mathillustrated @karenvaites @mikeandallie As a liberal parent, it is essential that you understand the following: telling people they cannot criticize newfangled curriculum or balooning ‘ed-tech’ budgets, is electoral suicide and the surest way to radicalize people against you

@karenvaites @mikeandallie Good news in education could go a long way, but there’s more money to be made in catastrophizing.

1/8 or so. This article has been showing up in my feed quite a bit over the last few days. The one thing I spent a lot of time studying is the claim about 2.8 years of math gains from a 4 week summer camp. Below are just some of the details I found about that claim.

@A_Trashcan @stepfanie Good thing you live in a country where capital and financing is exceptionally available! Oh wait you probaly want to destroy the financial and capital markets too, woops

@stepfanie Yes, I'll just start my own high barrier to entry company in a competitive industry. Why didn't I think of magically having the capital inherited from my father to buy all the equipment necessary and to keep my family fed while bussiness picks up.

You guys know if you create this much value you can just work for yourself right? You know you don't have to work for someone else's company right? You know you can start your own business online in about 45 minutes right? Yor so smort.

@Vincent7Dimarco @mert it's not so simple. Your GP would love for you to quit smoking, exercise more and take a statin. But They don't think you will

The answer to this question is simple: the medical system does not make it an objective to prevent disease. They only treat diseases that already exist or very high risk individuals. Only once preventing disease is an actual stated objective will they use first principles to achieve it

talked to 3 cardiologists since this and im left with the obvious question: why isnt the entire population on statins? LDL cholesterol is cumulative damage and irreversible the lower it is the better (without threshold) it seems to be extremely positive EV for anyone?

@MartinShkreli Bro this binds the receptor bro look at the assay bro curve go down bro we solved it bro it’s done bro pack it up

wait until they hear about pharmacokinetics

@autistictit @saaranghaeyo @MrDanielBuck Notable that you don’t bring up the clearest responsible party (parents), and propose a magical ‘teach better’ solution

@saaranghaeyo @MrDanielBuck Agreed. The "more work" is beyond the classroom teacher's capacity. My point though, is it is not the child's fault. Maybe not the teacher's fault either. But definitely not the child's.

“One student made 25 other students have a worse experience” Mercy to the cruel is cruelty to the innocent

@claudia68359127 @FuturistMarcus @BowTiedMara I’m good chief

@kaskarn @FuturistMarcus @BowTiedMara Study GeoPolitics and you shall understand

🇵🇪 This is how right-wing candidate Rafael López Aliaga closed his presidential campaign in Lima: “I’m not a politician, I solve problems. I’m going to reduce the state from 18 ministries to 6. I don’t care about the human rights of murderers; the Tren de Aragua project will be declared a military objective.”

@FuturistMarcus @BowTiedMara Why would Peru give a fuck?

@BowTiedMara I'm sure unwavering support for Israel and zionists is included somewhere as well.

@Drapp64262544 @CryptoMikli Good luck controlling the constellation of hungry biotech moonshot startups. If you can pull that off you should be a mind control illuminati company instead not selling medications as a business model

@CryptoMikli Yeah of course, unless you get so powerful that you control what medical research receives funding and snuff out anyone getting close to fixing an issue that fucks with your profits.

Martin Shkreli says believing Big Pharma hides cures is a “below 60 IQ take” “If you actually know anything about making medicine, you don’t half-make a medicine. You either make it or you don’t. The idea that companies would hold back a real cure makes no sense, because the first one to solve it wins everything”

@SAVESEPTA_NOW @harper_pau55997 @ByrneHobart yeah buddy the company with 1/10th the market cap of Apple is pulling all the strings. For sure my good dude. Awesome theory. Big brain

@harper_pau55997 @ByrneHobart is the power of petro capital not one of the primary reasons the usa launched a war of aggression against iran? whats your explanation

It’s a cool quote that becomes instantly self-refuting when you realize that you could say it today and get a positive reaction, but you’d have to use a completely different list of companies because those guys weren’t in charge after all.

@ContraPoints Wew that's wild someone should come up with a sort of think-science to systematically evaluate our motivations and decision-making

To be clear, I would not do arson because I have too many anxieties like "what if I go to jail?" and "what if the fire spreads and a single mom dies of smoke inhalation?" So I vote, I lib out—I stay in my lane.

See this I can respect. No LARPing here, an honest to god arsonist.

@cremieuxrecueil Fixed effect by household is pretty damn demanding unless those are very large households. Try random intercepts instead?

With a 2.5-times larger sample, I replicated this result, then it fell apart, and I figured out why🧵

@rthonbwooster @benryanwriter @whyvert ‘Severe TDS’ he’s a principled Catholic what do you expect?

@benryanwriter @whyvert Quite. I'm a free subscriber and he's certainly not "completely paywalled." He writes a lot less than he did, and has severe TDS, but all the same, can be interesting some of the time.

Used to hear a lot about Andrew Sullivan. But he hasn't tweeted in 3 years and his Subbstack is completely pay-walled. How to drop out of the discourse.

@AviBittMD Fair enough then, RIP a-OX40

@kaskarn HHV-8 screening is not sufficiently effective or standardized to reliably rule out future Kaposi sarcoma (KS) risk in someone starting an immunomodulatory therapy like rocatinlimab. Sensitivity and specificity is reported to be all over the place and is generally not reliable.

Kyowa and Amgen have terminated all clinical trials for rocatinlimab, an anti-OX40 antibody for atopic dermatitis, after a safety review linked it to cases of Kaposi sarcoma. The trial patients who developed KS did not have HIV (HIV patients were also excluded from the trial).

@AviBittMD I realize that; I meat screen for khsv/hhv8 which (I thought) isn’t found that commonly

@kaskarn The patients developed KS during the trial. They did not have KS before entering the trial.

@segal_eran @NatureMedicine Fig 1 can pry the tasty roll out of my hypoxic cold hands secondary to obesity-linked heart failure 😡

Our new study @NatureMedicine from the Human Phenotype Project: Analyzing diet and microbiome data from 10,000+ people, we found that what you eat is strongly linked to which microbes live in your gut, down to specific foods like coffee, yogurt, and milk driving distinct microbial signatures. We also simulate personalized dietary interventions with predicted microbiome shift effects that are associated with improvements in cardiometabolic health Read here: nature.com/articles/s4159… HPP: humanphenotypeproject.org/home

@PaulLes08530333 @loaibassam Mouais j'y crois moyen

@kaskarn @loaibassam Worked with a french company racking around 1.3M a year. Developed their own software using banks and shit. Cost them 20k and 4 months to develop it and now they pay 0.2% So yeah it’s possible

-.- I was about to celebrate.