Liling Wan

(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.110…

@PapapetrouMDPhD @ISEHSociety @beth_psaila Congrats Eirini!

So incredibly honored to receive this award by @ISEHSociety! Congratulations to the other awardees @beth_psaila and Ellen Rothenberg.

@bradylabupenn @TheModzLab @ASBMB Congrats Donita and thanks for all you have done!

Grateful to @ASBMB for this extraordinary honor and to the colleagues who nominated me. This recognition means a great deal because it affirms something I believe deeply: talent is universal, but access is not.

@MaayanLevyPhD @RogerRogergr @CellCellPress @MarcoRuella @Shan_Liu_ @PuneethGuru_ Congrats Maayan and team! Very interesting findings!

Excited to share our new paper in @CellCellPress with @MarcoRuella, led by @Shan_Liu_ and @PuneethGuru_. CAR T cell therapy loses effectiveness over time due to metabolic exhaustion, but we found a surprisingly simple approach to address it. 👇 cell.com/cell/abstract/…

@GMBurslem Huge congrats George! So well deserved!

Thank you to all the friends, collaborators, lab members and mentors who made this happen!

Just ~1 month until our @KeystoneSymp on Epigenetics and Gene Regulation in Health and Disease! keystonesymposia.org/conferences/co… @kjarmache and I have tailored this meeting around the unique basic and translational science in our field, addressing both challenges and new opportunities in moving mechanisms to successful drug development. Join us and reach out if you have questions!!

A short but wonderful visit at UCSF - thanks to Xiaokun @ShuLab2010 and Danica for the invitation to share our work on #epigenetics #condensates #cancer and to friends (old and new) for the great discussion! And so glad I made it home before the snowstorm shut everything down

@JunQiLab @PennMedicine @junwei_s Thanks for visiting us!

It was such a fun day to visit ⁦@PennMedicine⁩ and talk about science with ⁦@junwei_s⁩ ⁦@LilingWanLab⁩ and present our science. Thank you for having me.

@iannisaifantis1 So great to have you visit and share the beautiful work!

Taking the show to Philly and CHOP today!! research.chop.edu/events/ccgm-se…

@FilbinMariella @DanaFarber @BostonChildrens Congrats Mariella!

Incredibly honored to be part of this group! @DanaFarber @BostonChildrens

@LucasFarnung @TheMarkFdn Congrats Lucas!

Extremely honored to have been selected as a The Mark Foundation for Cancer Research Emerging Leader Award Winner. @TheMarkFdn, many thanks for your support!

@XDavidLiLab1 @nchembio Congrats David! Exciting results!

We have reported a series of first-in-class inhibitors for YEATS domain proteins since 2018, including an ENL inhibitor in 2018, an AF9 inhibitor in 2020, and now the first YEATS2 inhibitor. This work is now published in @nchembio nature.com/articles/s4158…

Congrats @Amgen @jaybradner and Dark Blue Therapeutics! Exciting to see ENL/MLLT1 biology advancing toward therapeutic translation in AML - a great example of how basic chromatin biology can inform new treatment strategies.

@JianXuLab @CD_AACR @StJudeResearch Congrats on the elegant study, Jian!

Excited to share our new study published online today @CD_AACR. Beyond mutagenesis, we show that LINE-1 locus-specific transcription reshapes 3D genome architecture to control cancer gene expression @JianXuLab @StJudeResearch aacrjournals.org/cancerdiscover…

@bloodgenes @usnews @DanaFarberNews @DanaFarber @BostonChildrens @HHMINEWS @broadinstitute Congratulations Vijay!!!

Honored to be recognized by @usnews as a 2025 #BestLeader with so many incredible colleagues and individuals I admire! usnews.com/news/best-lead…

@JianXuLab @StJudeResearch @yuefeng_1 @NorthwesternU Congrats Jian and team! Very cool mechanistic insights!!

Why did the first CRISPR gene therapy work so well in treating SCD and β-thalassemias? Our latest study provides the answer - CRISPR editing silences BCL11A through disruption of epigenetic insulation. doi.org/10.1182/blood.… @JianXuLab @StJudeResearch @yuefeng_1 @NorthwesternU

@KSusztak @ASNKidney Congrats Katalin!!

I am deeply honored to receive the 2025 Homer W. Smith Award from @ASNKidney. This recognition is not just mine — it belongs to the many people who shaped my path in science and medicine. 💙 #KidneyWeek

Check out the 2nd version of our preprint “RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription” and feedback welcome! biorxiv.org/content/10.110…

@jojdavies Congrats!!! And glad to see that Daniel is doing so well!

Our latest paper has just been published in Cell! doi.org/10.1016/j.cell… We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

@Goodell_Lab @Gandhar_Datar @therealDrGundry @BrunettiLab @RibackLab @bcmhouston Great to see this out! Congrats!!!

@Gandhar_Datar joined the lab when the world was shutting down, having just gotten started with guidance from @therealDrGundry and @BrunettiLab, who then moved on in their careers. Tough work in isolation until @RibackLab joined @bcmhouston, when informal chats got us thinking about the project in a whole new way. We considered how the aberrant function of NPM1c was related (or not) to its nucleolar WT function. A great collaboration grew, with Gandhar deeply learning both hematology and biophysics! Many ppl world-wide contributed and @sciencyelmira was the closer, getting the in vivo models working. Thanks to all, including the reviewers and editors for feedback.

@KSusztak @theNAMedicine @PennMedicine Congrats Katalin! So well deserved!

I am deeply honored to be elected to the @theNAMedicine From modest beginnings to this moment, I am profoundly grateful to my mentors, colleagues, trainees, and the incredible team in my lab — and to @PennMedicine and for their unwavering support in advancing precision nephrology. And to my family for their patience, endless love and support.