@BodyRecompExprt Please show me ANY piece of data that shows after 200mg of Test, you get “diminishing returns”. Literally any piece of data or source.
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Bill
39 posts
@Bill47577854 Why not contribute to the discussion, buddy?
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Anecdotal thoughts on TRT+ for non-competitive bodybuilding:
- After ~200mg testosterone per week, diminishing returns really start kicking in
- 0.1iu GH per 10mg testosterone seems like the sweet spot for GH
- If your protocol is negatively affecting your sleep it is absolutely unsustainable
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@karbonbased How you “tone”? 😂😂 please never give advice on gear, body fat, or muscle building again.
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Genetics definitely plays a role in how you tone but there's a lot of guys who lift but aren't willing to eat right or stop drinking so you end up with cope posts like "you're on steroids if you have abs"
Hybrid Athlete Guy@Hybridathlete
If someone has visible abs, defined delts/traps, and arm/leg vascularity: 1. They have really good genetics 2. They are taking steroids End of story.
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it’s incredible that the false narrative that cholesterol causes heart disease is still around.
It’s even crazier that big pharma are creating a one shot “gene therapy” that will likely have downstream negative “side” effects.
Stay away from such “magic fixes”!
Crémieux@cremieuxrecueil
Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!
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@Moveandstretch @AmmousMD Except this treatment is for people who have genetically high LDL that’s doing more damage than good.
You guys really need to find context before making these stupid claims. Also the brains LDL is all created local and not going out side of the blood brain barrier.
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The lower they push it the more pills they sell. That is not a coincidence. LDL is a transport system not a villain. When you suppress it artificially you interfere with hormone production, brain function, and cellular repair. But the prescription pad never asks those questions. Follow the money and you will always find the answer.
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Lowering LDL has been had disastrous consequences.
So naturally, pharma companies want to lower it more.
Chubby♨️@kimmonismus
One injection, 62% lower LDL - permanently. Gene editing for cholesterol is here. .@cremieuxrecueil is correct. Besides GLP-1 antagonist like Ozempic or, more recently, Retatrutide, this is probably the next breakthrough that is almost impossible to put into words. Verve Therapeutics (Eli Lilly) just published Phase 1 results for VERVE-102 in the NEJM. It's a single-infusion base-editing therapy that inactivates PCSK9 in the liver. At the highest dose, PCSK9 dropped 88% and LDL cholesterol fell 62%. Reductions held for at least a year. 35 patients with familial hypercholesterolemia or premature coronary artery disease. No dose-limiting toxicities. Main side effects: mild infusion reactions and transient liver enzyme elevations. Still Phase 1, still small, no cardiovascular outcome data yet. But the proof of concept for permanent, one-shot LDL reduction via gene editing is real. This is an absolute game changer and im not exaggerting. Elevated LDL cholesterol is responsible for an estimated 4.4 million deaths every year worldwide and remains the single biggest modifiable driver of cardiovascular disease, the leading cause of death globally.
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@carts85 @_9th_Life_ You mean other than the fact that it causes fat loss and retains muscle mass?
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@MicroCapWeekly @_9th_Life_ Except there isn’t a shred of proof this ever happens are replacement doses or ever higher doses, other than it being theorized.
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@_9th_Life_ Reta, Mots-C and that’s it. I never want to mess with Growth hormones because it could wake up aggressive cancer cells.
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@RedPilled1788 @TheGuySwann Yeahs the guy you’re responding to is an idiot.
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Our brains makes almost all of its own cholesterol locally. The blood-brain barrier blocks most circulating LDL from crossing over, so peripheral (blood) LDL levels have little direct impact on brain cholesterol supply. Lowering blood LDL mainly targets heart disease risk without depleting the brain's independent supply.
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This is the absolute most insane intervention imaginable.
Imagine what happens when they find out cholesterol isn’t the problem and happens to be one of the most important things for our brains… and they’ve made a permanent gene edit to “stop it”
Quite the opposite is going to happen of what they think. The medical industry is going to continue to be responsible for more and more deaths and chronic disease will keep exploding.
Our arrogance knows no bounds.
Crémieux@cremieuxrecueil
Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!
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What is one supplement that isn't a peptide or steriod that you swear by in your health and wellness regime?
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@JohnWebbMD @Crabtreeroad @pepfessions You’re not sure being able to eat more with a drug that is borderline anabolic and very good at nutrient partitioning is better than one that suppresses the heck out of your appetite?
Sir, turn in that MD credential. You’re demoted to front desk receptionist.
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@Crabtreeroad @pepfessions I gained 15lbs of muscle while losing 110lbs on Tirz. Not sure Reta is going to be "muscle sparing".. if one doesn't eat healthy, it doesn't matter which medicine they take.
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Switched from tirzepatide to retatrutide expecting magic. Got the same weight loss but my resting heart rate climbed from 62 to 84 and stayed there for 3 months. Reta is not tirz plus. It's a different beast and nobody talks about the cardiovascular load.
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@pepfessions Yeah Reta didn’t raise someone’s RHR 22 points. More propaganda.
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I agree with you in the sense that for obese individuals the benefits can be substantial. I take issue with people getting on it just to lose a few pounds… that leads to dependence because weight regain is common with this stuff if you’re not putting in the work. Not to mention a host of side effects that aren’t particularly pleasant.
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If you go on a weight loss drug such as a GLP-1 or similar just to shed a few pounds, you will likely become psychologically dependent upon these drugs for life. If you stop and regain the weight, which almost all do, you will find it extremely difficult to lose the weight again without the drugs. You then will be forever dependent on these drugs, something you may not have considered, The folks that “hop on a cycle of Reta” to get lean for the summer are going to be stuck on these drugs for life, or at least the vast majority will. Just watch it play out!
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@RhendaT9921 @SBakerMD Wrong. That’s not how it works. Please stop giving advice simpleton.
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@SBakerMD If those people would just cut the carbs and sugar, they'd drop weight. However, I know people who are addicted to carbs.
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@realEnnaM @SBakerMD “What happens when you stop?” Well if they don’t practice habits, they gain it all back. But atleast they lost the weight for whatever amount of time they were off it. That’s better than being obese for the entire time frame. Please use your brain.
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@TraceyPepperP @SBakerMD They would’ve lost their gall bladder either way. So what’s your point?
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@Right2Liberty @SBakerMD Yeah well those are people who don’t have will power or can’t commit to being healthy, either way they would be obese regardless. Getting the weight off for even one or two years will give them years of life back. There’s literally no downside when they would be fat either way.
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I’m already seeing it. People who have been on GLP-1s for one or two years and have tried to step down their dose immediately start gaining rapidly, complain that their “food noise” came back, their “full signals” disappeared again and state they know they can NEVER come off the drugs for the rest of their lives. Recipe for disaster.
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@CookResearcher @SBakerMD Well you’re wrong. But keep making claims without doing even a bare minimum amount of research.
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@SJ_SRQ @SBakerMD Yeah the muscle loss isn’t exclusive to GLP-1s. It happens with weight loss regardless of the way it’s done, unless the user is lifting and consuming enough protein. The amount of years of life someone will gain through weight loss, even with the muscle loss, is life changing.
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@SBakerMD The only ones winning in the end are big Pharma. Not to mention, one too many cases of major muscle loss. You could make a case for severe obesity, but getting on a never ending cycle of these drugs because you simply wanted to drop a few pounds for summer is insane.
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@SBakerMD It’s almost like you should worry about yourself. People who want or have the will power to maintain their gains or loss’ will. It’s the same with any performance enhancing drug. The difference being, they can add years to their life, by getting their weight down for a bit.
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@ThePepGuy I’m running Reta forever. Until something better comes out.
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If you had to choose only one Peptide or similar compound to run forever, which would it be and why?
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