Christoph Stein-Thoeringer, MD

What a news week for microbiome interventions in cancer immunotherapy! Three major studies published in @NatureMedicine. Congratulations to all scientists&physicians in these consortia for such amazing work. nature.com/articles/s4159… nature.com/articles/s4159… nature.com/articles/s4159…

Excited to share a milestone published in @NatureMedicine from our decade-long effort to build The Human Phenotype Project, a unique longitudinal cohort with unmatched depth of clinical and multi-omic profiling, enabling truly predictive, personalized medicine. Led together with @ericxing, it is a global collaboration between @WeizmannScience, @MBZUAI, and Japanese partners, spanning 30,000+ participants and continuing to grow internationally By devising AI models trained on individuals deeply profiled with genetics, microbiome, glucose, sleep, bone density, and more, we can now forecast diseases before symptoms appear and simulate treatment or lifestyle outcomes. Key findings: • Re-defined metabolic risk thresholds • Predicted menopause impact via biological aging • Mapped organ-specific aging trajectories • Developed models for early detection of diabetes & heart disease This dataset is a blueprint for digital health twins, AI-driven tools grounded in real-world, longitudinal data Data access: humanphenotypeproject.org Full paper: tinyurl.com/4kftyndh Thanks to all the people who led this work: Lee Reicher, Smadar Shilo, Anastasia Godneva, Guy Lutsker, Liron Zahavi, Saar Shoer, David Krongauz, Michal Rein, Sarah Kohn, Tomer Segev, Yishay Schlesinger, Daniel Barak, Zachary Levine, Ayya Keshet, Rotem Shaulitch, Maya Lotan-Pompan, Matan Elkan, Yeela Talmor-Barkan, Yaron Aviv, Maya Dadiani, Yonatan Tsodyks, Einav Nili Gal-Yam, Haim Leibovitzh, Lael Werner, Roie Tzadok, Nitsan Maharshak, Shin Koga, Yulia Glick-Gorman, Chani Stossel, Maria Raitses-Gurevich, Talia Golan, Raja Dhir, Yotam Reisner, Adina Weinberger, Hagai Rossman, and Le Song And special thanks to all participants of the Human Phenotype Project

@Elinav_Lab @MichaelDJain @_MichaelBaumann @DKFZ @helmholtz_en What a tragedy. Very sorry to read that. Hope this terror ends soon and you all stay safe.

48h since lab destroyed 😭😭 People safe, thx god. Deeply thankful @_MichaelBaumann @DKFZ & Otmar_Wiestler @helmholtz_en for reaching out to us w leadership & support. Will continue updating on support and leadership, while considering w colleagues our next chapter- suggestions?

Incredibly proud to be part of a highly motivated team of scientists to bring a novel T cell therapy against pancreatic cancer into clinical development. A journey to new frontiers.[ dekade-gegen-krebs.de/de/wir-ueber-u…

Cellular atlases are unlocking the mysteries of the human body nature.com/articles/d4158…

Balancing act: counteracting adverse drug effects on the microbiome: Trends in Microbiology cell.com/trends/microbi…

Nature Jobs: nature.com/naturecareers/… academics.com #SPCoLCx0w7xiaW5nZW4=" target="_blank" rel="nofollow noopener">academics.com/jobs/independe… Uni Tübingen uni-tuebingen.de/universitaet/k…

Enjoying the sun and warm weather as summer ends with a relaxing lab outing with BBQ in the fields outside Tübingen!🍢🍺🍢

@DrMvandenBrink Extraordinary gift and definitely the perfect place and environment to drive innovation in PDAC therapy.

Stephenson Prize for Innovation in Pancreatic Cancer Research cityofhope.org/stephenson-pri…

📣 Major milestone reached: 10,000 CAR-T treated #patients registered in the #EBMT Registry! 🙌 📈 This achievement highlights the incredible progress and growing impact of chimeric antigen receptor T-cell (CAR-T) therapy in treating haematological malignancies. 🔬 We are very grateful to our scientific community for all your input! 🙏 Read the full story and discover how this breakthrough is shaping our future ⬇️ ebmt.org/ebmt/news/ebmt… #CART #CellTherapy #MedTwitter #MedicalMilestone #Haematology

Really excited that our curatedFoodMetagenomicData resource is out in @CellCellPress! 2,500 food metagenomes and their link with the human microbiome. Thanks to first author Niccolò Carlino, @nsegata @pauldcotter @DaniloErcolini and all @MASTER_IA_H2020 colleagues

What is important for long term survivors after CAR T cell therapy? More and more patients are several years out from this amazing therapy. How should we manage them? In ascopubs.org/doi/full/10.12… we report on 5 year outcomes of standard of care lymphoma patients. 🧵

Chemotherapy is still the major backbone of therapy against pancreatic cancer. But now it’s time to think about microbiome and chemotherapy, a heavily ignored interaction. See our comprehensive thoughts on this topic lead by ⁦@julicast80⁩ and team! tandfonline.com/doi/full/10.10…

@tmslab2022 @julicast80 @vdmbrsv Great work, Juliana and team members and collaborators! Thanks #ESMOGI24

Prime news from TMS lab: Our poster, “Gut microbiome profiles as a novel predictor of tumor response to chemotherapy in pancreatic cancer patients,” by Dr. Juliana de Castilhos @julicast80, Dr. Vadim Boris @vdmbrsv, and Julia Galeeva, won the Best Poster Award at ESMO Congress.

Very important piece of work for ID specialists and microbiome scientists! nature.com/articles/s4158…

@MichaelDJain @MoffittNews Congratulations!

It has been a long journey by a lot of dedicated scientists and investigators ⁦@MoffittNews⁩ and across the world - but TIL therapy is standard of care now for melanoma!

@JulioSaezRod @emblebi @embl @jomcentyre Congrats!

Excited to be (back) @emblebi - now as Head of Research. I very much look fwd to helping nurture research (leveraging its trove of resources #services + unique possibilities within @EMBL) + support @emblebi as a whole as part of its Senior Management Team (congrats @jomcentyre!)

This research on colon cancer biomarkers "serves as a pivotal wake-up call for current microbiome research, offering solutions to propel the field forward." nature.com/articles/s4159… nature.com/articles/s4159… @NatureMedicine @ancientOmics @jeroenraes @zhu_ruixin

@BLLPHD @EWhiteheadFdn Happy anniversary. This journey is a huge inspiration!

Happy CAR T Anniversary Emily Whitehead #OTD 2012 #immunotherapy #TCell #tcellrx @EWhiteheadFdn emilywhiteheadfoundation.org/our-journey/