Wall Street

@elonmusk Less people means cheaper houses

This collective suicide of humanity needs to turn around!

@beyoumf Buying a yacht

After getting rich, what's next?

@phil_mcalister @MarkGabriele22 Why don’t these politicians just do a better job??? Wouldn’t that be something.

@MarkGabriele22 I think that they could likely borrow against their shares, liquidate a few things across the board, etc and get there without a massive disruption.

If I were one of these billionaires she's always blasting, I'd call up my fellow billionaires and pitch them an idea: Let's all put 3% of our wealth into a fund, and use the money to start businesses and non profits thst solve highly impactful problems for the country. Show the difference in outcomes when private, motivated people with a stake in the success do something vs. when the government confiscates and squanders resources

@MarkDiStef Trump should give him a green card

Omfg 21 members of the SAS testified against him!!!

@elonmusk The problem is that nobody cares anymore.

Wow

@elonmusk @pmarca How far away is this future exactly?

@pmarca Working will be optional in the future

AI employment doomerism is rooted in the socialist fallacy of lump of labor. It is wrong now for the same reason it’s always been wrong. More people really should try to learn about this. The AI will teach you about it if you ask! (Hinton is a socialist. youtube.com/shorts/R-b8RR6…)

@EYakoby The problem is that Iran can just replace all these people 3-4 time over

“Iran is winning.”

@devchart Does anyone even know what is happening day to day with Iran?

Trump is just changing his mind every day and inventing new scenarios... Does he even have any advisor around him ?

@HealthyAlfred Hard to know what is real these days

They cut a rat’s knee ligament CLEAN THROUGH. Gave it oral BPC-157 in drinking water. 100% recovery. Biomechanically. Functionally. Structurally. From DRINKING WATER… (PMID: 20225319) Your knee hasn’t been the SAME since that twist. Your shoulder BUCKLES when you press. Your ankle still GIVES OUT on stairs. You were the one who never sat out. Never skipped a session. Never made excuses. Now you modify EVERYTHING. And at some point you stopped believing it would heal. You just protect it now. Ligaments barely get blood flow. That’s why yours has been “almost healed” for 2 YEARS. Almost. Never fully. Never COMPLETELY. BPC-157. 15 amino acids. Already in your stomach juice. Not invented — DISCOVERED. → Severed ligament: COMPLETE recovery → Oral: IDENTICAL results to injection → Adverse effects: NONE found (PMID: 20225319) → NSAID damage reversed: ORALLY (PMID: 21295044) → Intestinal fistulas closed: via DRINKING WATER (PMID: 34267654) Ibuprofen? Numbs the signal your body needs to START healing. BPC-157 → fibroblasts activate → collagen organizes → ligament REBUILDS Week 2-3: Stiffness LOOSENING Week 4-6: Stability RETURNING Week 6-8: Loading without FEAR My knee was unstable for over a year. I could walk fine. But every squat, every cut, every unexpected step — I BRACED. Started oral BPC-157. Week 3 the joint felt noticeably tighter. Week 8 I squatted without the brace. The knee held. Not perfect — but the first time in a year it was getting STRONGER instead of just surviving. Your ligament isn’t “just like that now.” It never got the signal to FINISH. CHECK COMMENTS FOR BPC-157! Rest HOPES for healing that never comes. BPC-157 SENDS the signal to complete it. BPC-157 is not FDA-approved. Preclinical evidence. Not medical advice.

@SenWarren Nobody needs to watch Netflix. If you don’t want to pay the fees, don’t subscribe. It’s that easy.

Netflix just got a $2.8 BILLION payout from Paramount for its failed Warner Bros. deal. Then Netflix turned around and raised prices on millions of customers.

@HayekAndKeynes Makes sense, they have probably worked for 40-50 years

People over 70 hold over 30% of US wealth

There's a $101 million competition happening right now to extend human healthspan. Not in mice. Not in worms. In people. XPRIZE Healthspan launched in 2023 and runs through 2030. The goal: develop a therapy that restores muscle, cognitive, and immune function — all three — by 10 to 20 years in people over 50. The treatment must take one year or less. robertlufkinmd.substack.com/p/744-teams-ar…

@davidasinclair I wonder how long David expects to live if no ground breaking advances in anti aging are made. I know people that were moderate drinkers that lived into their late 80s.

For $1M, I wouldn’t START drinking again

@ImtiazMadmood I personally know a dentist that would do it in 30mins

In a landmark medical technology milestone, a fully autonomous AI-powered robotic dentist — built by US company Perceptive — completed a full crown preparation on a human patient in just 15 minutes. The same procedure typically takes a human dentist 2–2.5 hours. The robot used real-time 3D scanning, AI decision-making, and a precision robotic arm to perform the entire procedure without any human guidance or intervention mid-surgery. This isn't a concept or prototype — it's already been performed on real patients and a peer-reviewed study was published in the Journal of Dentistry in January 2026. Experts say this is the beginning of a transformation: robotic dentists could eliminate human error, work at any hour, and eventually bring high-quality dental care to remote and underserved communities where trained dentists are unavailable. The dental office of 2035 may look very different from today's.

@elonmusk @_kaitodev @garrytan @karpathy I don’t think/trust the government will be so generous. Maybe universal low income

@_kaitodev @garrytan @karpathy All jobs will be optional. There will be universal high income.

5 minutes ago, @karpathy just dropped karpathy/jobs! he scraped every job in the US economy (342 occupations from BLS), scored each one's AI exposure 0-10 using an LLM, and visualized it as a treemap. if your whole job happens on a screen you're cooked. average score across all jobs is 5.3/10. software devs: 8-9. roofers: 0-1. medical transcriptionists: 10/10 💀 karpathy.ai/jobs

@TheUnsaid11 @grok @greekdev @IterIntellectus If the cancer ‘regrew’ after 2 years couldn’t you just repeat the treatment against the new cancer cells?

@grok, this is potentially useful, but there may be caveats, correct? Mutation rate of cancer cells may evade a vaccine created for a specific sequence. A remission of 2-3 years is a huge win for a short lived dog. Would a strategy of sequencing multiple samples of human cancer cells & creating targeted vaccines for variants, plus periodic sequencing & new vaccine of mutated cancer cells if there is remission... be a good strategy? What would be a better strategy for cancer in humans?

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

@barkmeta I’ve never used chat gpt for anything that Google search couldnt tell me. What makes him think I’ll pay a monthly fee for it 😂 the world existed before these ai models and I don’t need to pay some exorbitant fee for them

Let me get this straight… OpenAI was founded as a nonprofit. Open source. For everyone. “To benefit humanity.” Then he raised billions of dollars. Then he closed the source code. Then he converted to for-profit. Then he scraped the entire internet without asking anyone. Then he used YOUR writing YOUR art YOUR code to train his models. Now he’s on stage saying you’ll pay HIM to access intelligence. Just like a water meter. He stole all of your data. He built the product with your work. And now he’s going to bill you to use it… Corporate greed has reached an all time high, and they’re not even hiding it anymore…

@shanaka86 Can’t someone else provide insurance? We can put people on the moon, surely it can’t be that hard.

BREAKING: China is pressuring Iran to reopen the Strait of Hormuz. There is one problem. Iran did not close it. Seven insurance companies in London did. China buys 80% of Iran’s shipped oil. Beijing has a $400 billion, 25-year cooperation agreement with Tehran. China is Iran’s economic lifeline. If any country on earth has leverage over Iran, it is China. And China is now using that leverage to demand the Strait reopens. But the Strait was not closed by a sovereign decision. It was closed by the withdrawal of reinsurance capacity from five to ten firms, mostly in London, backstopping twelve P&I clubs that cover 90% of global tonnage. Iran did not order those firms to withdraw. Iran cannot order them to reinstate. Neither can China. Even if Tehran capitulates entirely tonight and the IRGC stands down, not a single reinsurer reinstates Gulf war risk coverage on a phone call from Beijing. Reinstatement requires rebuilt risk models, voyage-by-voyage re-underwriting, repriced treaty capacity, and a threat environment that actuaries can quantify. None of that exists while 440.9 kilograms of weapons-grade uranium remains unaccounted for and the IRGC is still launching drones at Oman. China has leverage over Iran. China has zero leverage over Lloyd’s of London. This is the part nobody is modelling. The country with the most to lose and the most leverage over the belligerent cannot fix the mechanism that actually closed the Strait. Because the mechanism is not geopolitical. It is actuarial. And actuaries do not take calls from the Politburo. open.substack.com/pub/shanakaans…

Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults nature.com/articles/s4159…

Peter Thiel literally gave a 17-minute masterclass on Zero to One blueprint to escape competition and build a monopoly: