ISD Research

Incredibly happy and proud to share our newest work in @ScienceTM showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to to first authors @SebRoemer and Fabian Wagner! science.org/doi/10.1126/sc… Thread below

Martin Dichgans among „Highly Cited Researchers 2024” clarivate.com/highly-cited-r… 🙌

The ISD co-organized the 9th International Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to English Garden/Munich. Experts presented latest developments in CAA research ranging from basics in research to studies in humans...

ERC Starting Grant 2024 for Anna-Sophia Wahl and her team for studying fundamental principles of neuronal repair after stroke. isd-research.de/isd-research-n…

Did you ever wonder why the risk for subsequent vascular events is increased after a first stroke or MI? Our answer, out now in @Nature nature.com/articles/s4158… A story about NETosis, DNA-sensing and inflammasome activation. Spearheaded by @StefanRoth86 and Jiayu Cao.

Finally out today! Very proud of this story: Innate immune memory after Stroke drives remote organ pathology This study was led by superstar-postdoc @SimatsAlba and X-less Sijia Zhang. @CellCellPress cell.com/cell/fulltext/…

Authors from @ISD_Research, @unidue_zmb and colaborators develop repair approaches to reverse the effects of pathogenic mutations in protease HTRA1. nature.com/articles/s4146…

Excited to share our newest work showing that neuroinflammation parallels tau spread in 4R tauopathies, suggesting a key role of microglia in tau progression. Many thanks to @M_Malpetti, @RoemerSeb, @johanneslevin, @GunterHoglinger and @matbrendel doi.org/10.1002/mds.29…

October 15-17 9th ICAA in Munich, ISD co-organizing 9th Interational Conference on Cerebral Amyloid Angiopathy in Munich. Experts will present latest developments in CAA research ranging from basic research to studies in humans. Sign up now: icaaconference.org/registration-d…

ISD teams gathered for annual scientific retreat to present their projects and discuss work. There were presentations from Ph.D. students, a poster session, invited speaker talks, and an amazing three minute thesis competition. @PaquetLab @JekyllSarah @mgeorgakis1

The 30th ISGC Workshop is in full swing! Thank you to everyone contributing to talks, posters and vivid discussions 🧠🩸🧬🔬 And a big thank you to our host @rainermpg and the @ISD_Research 🎉✨️🎊

What honor to host the ISGC workshop, here at the preciousLMU St.-Vinzenz-Haus Munich City Great Keynote Lectures and Scientific Sessions and social activities #strokegenetics strokegenetics.org

Very excited to share that our DELiVR method is now open access published @NatureMethods. We created a simple, brain-wide cell analysis deep learning tool, no coding needed! Fiji Plugin makes it accessible to all. nature.com/articles/s4159… by @Dorie00 @Rami96614090 @moritz_negwer

Age-related decline in brain endothelial cell (BEC) function contributes critically to neurological disease.(…) A study by isd investigators 👉@katalin_volgyi @Judit_GonzalezG et al. just published on @NatureAging read more here isd-research.de/isd-research

#OriginalResearch: Proteogenomic data integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis #AHAJournals ahajrnls.org/47une7c

Super happy to share our new work out in @NatureComms, showing that synaptic changes accelerate amyloid-related tau accumulation and spread in #Alzheimer's disease. Many thanks to @_michael_scholl and many others! @ISD_Research, @goteborgsuni doi.org/10.1038/s41467…

First results from 2,500 individuals from eMERGE, a study developed to test genomic risk assessment at a population level. Important PRS data for 10 diseases on: 👉performance 👉feasibility 👉medical actionability 👉translatability nature.com/articles/s4159…

Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo academic.oup.com/brain/article-…

A useful resource on the national prevalence of carotid atherosclerosis in China (>10M individuals) @JAMANetworkOpen 👉 increased cIMT (>1mm): 26% | 93% (!) for >80y 👉 plaque: 21% | 87% (!) for >80y 👉 stenosis: 0.6% | 4% for >80y jamanetwork.com/journals/jaman…

We are happy to present the new BRENDA Leducq Website with all information about the project, talks, meetings, and other news #brenda @FondationLeducq brenda-leducq.de/brenda