Scicomm Media

My conversation with Marc Andreessen (@pmarca), co-founder of @a16z and Netscape. 0:00 Caffeine Heart Scare 0:56 Zero Introspection Mindset 3:24 Psychedelics and Founders 4:54 Motivation Beyond Happiness 7:18 Tech as Progress Engine 10:27 Founders Versus Managers 20:01 HP Intel Founder Legacy 21:32 Why Start the Firm 24:14 Venture Barbell Theory 28:57 JP Morgan Boutique Banking 30:02 Religion Split Wall Street 30:41 Barbell of Banking 31:42 Allen & Company Model 33:16 Planning the VC Firm 33:45 CAA Playbook Lessons 36:49 First Principles vs. Status Quo 39:03 Scaling Venture Capital 40:37 Private Equity and Mad Men 42:52 Valley Shifts to Full Stack 45:59 Meeting Jim Clark 48:53 Founder vs. Manager at SGI 54:20 Recruiting Dinner Story 56:58 Starting the Next Company 57:57 Nintendo Online Gamble 58:33 Building Mosaic Browser 59:45 NSFnet Commercial Ban 1:01:28 Eternal September Shift 1:03:11 Spam and Web Controversy 1:04:49 Mosaic Tech Support Flood 1:07:49 Netscape Business Model 1:09:05 Early Internet Skepticism 1:11:15 Moral Panic Pattern 1:13:08 Bicycle Face Story 1:14:48 Music Panic Examples 1:18:12 Lessons from Jim Clark 1:19:36 Clark Versus Barksdale 1:21:22 Tesla Versus Edison 1:23:00 Edison Digression Setup 1:23:13 AI Forecasting Myths 1:23:43 Edison Phonograph Lesson 1:25:11 Netscape Two Jims 1:29:11 Bottling Innovation 1:31:44 Elon Management Code 1:32:24 IBM Big Gray Cloud 1:37:12 Engineer First Truth 1:38:28 Bottlenecks and Speed 1:42:46 Milli Elon Metric 1:47:20 Starlink Side Project 1:49:10 Closing Includes paid partnerships.

My conversation with @brian_armstrong, co-founder and CEO of @coinbase and @newlimit. 0:00 Crypto Power in DC 0:25 Market Structure Clarity 1:39 SEC Lawfare Origins 5:49 Suing the Regulator 9:09 Winning the SEC Case 11:11 Long Term Founder Mindset 12:20 Autism and Focus 15:04 Mission First Company Culture 21:10 Rebuilding From Scratch 23:05 Follow Your Nose 25:20 From Side Hustles to Coinbase 30:07 Argentina and Bitcoin Spark 32:33 Airbnb to Coinbase Nights 36:25 Finding a Co-founder 37:35 YC Without a Co-founder 38:41 Finding the Perfect Partner 40:18 Losing Money Per Trade 41:23 Support Backlog Chaos 43:29 Banking and Compliance Gauntlet 47:47 Raising Fast to Survive 51:36 Mission Values and Inspiration 57:54 Hiring for Spikes 1:02:14 Centralized vs Decentralized 1:05:51 From Bitcoin Wedge to Super App 1:07:59 How Coinbase Runs Today 1:11:00 Decision Speed and Risk 1:12:43 Internal Venture Bets 1:14:46 Funding Ideas Internally 1:15:18 Coinbase Marketing Experiments 1:16:56 Internet Native Shareholder Updates 1:21:58 Media Diet and Going Direct 1:26:47 Building a New Industry 1:31:44 Starting New Limit Longevity 1:36:17 CEO Stress and Routines 1:40:59 AI Agents at Coinbase 1:44:35 Base App Explained 1:46:47 Other Bets and SEZs 1:49:21 Closing Thanks Includes paid partnerships.

My conversation with @JasonFried, co-founder of @37signals. 0:00 Build Products for Yourself 1:40 Low Costs, Small Company, Enough Customers 3:06 Your Only Competition Is Your Costs 5:25 How 37signals Stays Lean 9:43 Rewriting Basecamp & Fighting Software Bloat 13:42 Why "Enough" Beats Growth 17:44 Product People vs. Business Shells 22:41 The "So What?" Mindset 27:45 Staying Close to Customers 34:43 The Reward for Good Work Is More Work 39:57 Six-Week Horizons & Compounding Decisions 45:20 Anti-Fragile Business With Tiny Units 50:55 Galápagos Product Design 52:44 Radical Authenticity Over Marketing Tricks 1:27:39 Rick Rubin & Intuition-Driven Building 1:42:25 Lightning in a Bottle & Knowing When to Stop 1:50:29 Defining Success: Pride in the Work 1:53:58 Independence Through Profitability 1:59:23 When Tech Adds Friction Instead of Value 2:04:11 Ruthless Editing & What Never Changes 2:08:14 Longevity as the Moat 2:17:28 Building by Intuition Includes paid partnerships.

Tomorrow’s Huberman Lab episode is with Dr. Lauren Colenso-Semple (@drlaurencs1), PhD, an expert in strength training, muscle building and nutrition. Dr. Colenso-Semple and @hubermanlab discuss the most effective resistance and cardiovascular training programs for women, including program design, exercise selection, sets, reps and rest periods, how menstrual cycles, menopause and birth control impact fitness outcomes, and dispel common myths about women’s training, fasting, cortisol and supplementation.

My conversation with Jimmy Iovine (@jimmyiovine_), co-founder of @Interscope Records & @BeatsbyDre. 0:00 The Corny World of Fame 0:54 The Impact of Social Media on Fame 1:27 Chasing Greatness: Personal Reflections 2:10 Technological Shifts in the Music Industry 3:24 The Streaming Service Dilemma 5:34 The Artist's Perspective on Streaming 6:39 Early Career and Influences 9:40 The Importance of Humility 11:19 Working with the Best: A Career Retrospective 13:07 The Role of Brutal Honesty 15:00 Navigating the Music Industry 33:50 The Birth of Beats by Dre 46:14 The Music Industry's Customer Problem 46:44 Vertically Integrating Culture and Fashion 47:13 Building Beats: From Music Videos to Headphones 48:03 Marketing is Empathy 50:28 The Journey of Beats Music 59:09 The Future of the Music Industry with AI 1:14:40 The Bend in the Pipe: Harnessing Fear and Obsession 1:29:12 Comparing Work Approaches with Dr. Dre 1:30:50 The Tortured Path to Success 1:32:41 Balancing Happiness and Ambition 1:35:22 The Importance of Peace and Therapy 1:49:30 Learning from Legends 1:55:57 The Influence of Bono and Dre 2:00:15 California Dreams and Career Milestones 2:07:20 Final Thoughts and Reflections Includes paid partnerships.

Jimmy Iovine. Interscope Records & Beats by Dre. Tomorrow. February 1, 2026. Available everywhere you get podcasts. @jimmyiovine_ @Interscope @beatsbydre

Tomorrow’s @HubermanLab episode is with @Dorian_Yates, six time Mr. Olympia champion (1992-1997) and overall fitness legend. They talk about how to build muscle while spending less time in the gym (high-intensity, low-volume training), along with other topics such as elite performance, hardship and motivation, cannabis use, psychedelics, and more.

Tobi Lütke. Shopify. Tomorrow. January 18, 2026. Available everywhere you get podcasts. @tobi @Shopify

There are good habits, and there are Atomic Habits. 💥 Author and human behavior expert @JamesClear stops by @hubermanlab to talk to host Andrew Huberman about how to make a change for the better. apple.co/HubermanJC

Tomorrow's Huberman Lab episode is with @JamesClear, author of Atomic Habits and expert on behavior change and habit formation. James and @hubermanlab discuss a simple framework for building habits that last—without relying on motivation or willpower. James explains why "getting started" is so critical and how to make habits stick even on bad days. They also cover how to break bad habits. No matter what your goals are for 2026, this episode offers actionable, zero-cost tools to build lasting habits.

John Mackey. Whole Foods Market. Tomorrow. January 4, 2026. Available everywhere you get podcasts. @iamjohnmackey

Tomorrow’s Huberman Lab episode is with Twyla Tharp (@TharpTwyla), a world-renowned dancer and one of the most accomplished choreographers of the last century. Twyla and @hubermanlab discuss how creative success grows out of disciplined routines and the deep connection between movement and thought. They also cover practical tools for fostering creativity through consistent habits. This episode offers insights from a world-class creator on tapping into your own creativity and achieving excellence.

James Dyson. Tomorrow. December 7, 2025. Available everywhere you get podcasts. @Dyson

These shows ruled your rotation. Check out the 10 most popular shows on Apple Podcasts this year: 1. The @joerogan Experience 2. The Daily (@nytimes) 3. The @melrobbins Podcast 4. @CrimeJunkiePod 5. @DatelineNBC 6. @SmartLess 7. @callherdaddy 8. @ThisAmerLife 9. @hubermanlab 10. The @ezraklein Show apple.co/TopCharts2025

Here are the Global Top Shows of 2025 🌎 #SpotifyWrapped

Tomorrow's Huberman Lab episode is with Dr. Thais Aliabadi (@AliabadiMD), a board-certified OB/GYN, surgeon and a leading expert and advocate in women's health. Dr. Aliabadi and @hubermanlab discuss women's hormone and fertility health, focusing primarily on the two leading causes of infertility, PCOS and endometriosis. They also discuss broader women's health topics such as breast cancer, menopause, fertility and more. Thanks to Dr. Aliabadi, this episode offers potentially life-changing information for women of all ages, empowering them to take control of their reproductive and overall health.

Michael Ovitz. Creative Artists Agency (CAA). Tomorrow. November 23, 2025. Available everywhere you get podcasts.

Thank you @ApplePodcasts & listeners of the Huberman Lab podcast. Apple released their 2025 rankings and I’m honored and delighted that so many people enjoy learning about health & science! apple.com/newsroom/2025/…

Starting tomorrow, Huberman Lab is black on black. Apologies for starting the wooden slat trend! This feels a lot better visually. @hubermanlab // @scicomm