Christopher Garris

@iskander The Rubinsteyn method.

Trick I've found useful for analyzing tumor RNA: zero out mitochondrial genes (including mt-tRNA), NUMTs, rRNA, rRNA pseudogenes, & MALAT1/NEAT1. Renormalize TPM (so values add up to 10^6). Cleans up noise from sample degradation, enrichment method, &c Does this have a name?

Researchers led by Drs. Tanner Johanns, Niranjan Sardesai, and @GavinPDunn have shown that the personalized #DNAVaccine GNOS-PV01 safely triggers anti-tumor immune responses in #glioblastoma patients and shows promising early survival benefits in a phase 1 clinical trial. 🧬💉 Read the @NatureCancer study: go.nature.com/4dEQdLP

@csgarrix @kochinstitute @MITChemE @MGHCSB @BostonChildrens @harvardmed @Das_Riddha A new approach to cancer vaccination yields more powerful T cells #NBTintheNews news.mit.edu/2026/new-appro…

An innovation taking mRNA-nanoparticle cancer vaccines to the next level for potency and durability @NatureBiotech nature.com/articles/s4158…

Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models go.nature.com/42td2fh

@silvirouskin Maybe Verve, now part of Eli Lilly, has something related to that. They were big into gene therapies for cardiovascular diseases.

This is crazy - I have a high risk for heart disease and I only found out because I did my own blood testing out of pocket. Both my grandfather and my mother died of heart attacks in their 50s. And my PCP was like “oh you’re fit , you have low fat, you’re fine” CHECK IT OUT : typical test (left) , in depth test (right). Turns out I am genetically predisposed for a heart attack- very high lipoprotein(a). And there are available treatments including an mRNA therapeutic in trials right now !🥹😭I may be able to escape the destiny that likely took away my mom !

Thrilled to share our @NatureBiotech paper using mRNAs that generate stronger and durable T cell responses by driving DC maturation and activation. This work highlights how defined immune-signaling pathways, paired with controlled delivery, can shape potent therapeutic immunity.

Thrilled to share that a major work from my postdoc is now published @NatureBiotech on #mRNA encoding immune-regulatory signals for #cancer #immunotherapy! Amazing collaboration between @kochinstitute and @MGHCSB, @MassGenBrigham. nature.com/articles/s4158…

@simone_minnie @drjgauthier To play Devil’s advocate they also upped the funding $$ per DP2 considerably, meaning less awards overall will be issued.

@drjgauthier DP2 is also supposed to hit record low success rate this year 🙃

😭😱

@YosukeKumamoto @Rutgers_NJMS Congratulations Yosuke!

Just got tenured @Rutgers_NJMS. I want to thank all of my lab members, mentors, collaborators and colleagues current and past, anonymous letter writers and my family. Thank you all for your support!!

@simone_minnie California thing. People appear nice, but can be mean behind closed doors. East coast, people appear mean, but actually can be quite nice.

@csgarrix I do wonder how much of this is institute/coast specific 😉 At UCSF, everyone I’ve met is super supportive and friendly….including the ‘cool’ kids haha.

Being a new PI is literally just guessing at things and hoping you get it right. Ie. Never written a statement of work for a CRO before? Here. Fill out this very vague template. Just me over here googling KPIs and deliverables and hoping for the best…

@ChrisRodell2 @simone_minnie I’d always sit with you CRo.

@csgarrix @simone_minnie I'm here. Wanna sit at my lunch table? (CSB former 'tea' room counts)

Online now: Pharmacologic glycoengineering of Fcγ receptor IIIa enhances force-resistant IgG-FcγR interactions and anti-tumor antibody efficacy dlvr.it/TSCfRY

@silvirouskin There ought to be a rule that if your proposal bounces around that many times and no one is qualified to review it that it is de facto novel and innovative and deserves at least an automatic modular R01.

Apparently my R01 is so interdisciplinary that no known branch of NIH is qualified to review it. I spend months writing it, and it was bounced off 3 different sections until it was WITHDRAWN. We are soon submitting this work to Science. Great support of innovative research. 💀

A coat of sialylated protein protects human leukemia cells from destruction @ScienceMagazine @joohochung @massgenbrigham @MangusoLab @BroadInstitute science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

Online now: Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment dlvr.it/TRr9hd

@iskander Healthy skepticism is valid over the naive enthusiasm, but this is like educating overzealous students. This is net favorable publicity… until the bio hacker cytokines storms hit. Hopefully that doesn’t happen.

Wow, I can’t believe you can just cure cancer with ChatGPT and mRNA vaccines. The important insight was that biology is a lot like programming.

@iskander On the bright side at least it isn’t an army of zealots vehemently opposed to the technology. They may be thoroughly misguided, but maybe that’s baby steps towards public acceptance and positivity? 🤷‍♂️

This is all I do for work and you all are slowly driving me insane.

@casanova_lab Congratulations on the move. Did you know there is also a Paris in Texas? en.wikipedia.org/wiki/Paris,_Te…

9/ Dallas, the birthplace of the frozen margarita machine, is the 9th largest US city (4th when combined with Fort Worth), has the largest contiguous urban arts district in the US, and boasts more restaurants per capita than NYC (more studies are needed to confirm this claim!😉).

1/ We are thrilled to announce that our American branch of the Laboratory of Human Genetics of Infectious Diseases (HGID) will relocate to @UTSWMedCenter in Dallas, Texas, effective July 1, 2026 J