Kyle Marieb

@mayfer My cochlea doesn’t have cilia so I’m deaf; my cochlear implants perform a digital FFT (thanks to the algo nerds for making it O(n*logn)) to map the incoming sound in the mic to which electrodes on the array laying on the cochlea get turned on.

In other words, and this is mostly just vibes based, I don’t think anyone knows exactly how it plays out, but if capital completely decouples from labor and most workers aren’t “needed” in a sense, I just think that means high welfare or UBI for everyone via cheap goods and services more than it means those people will just get completely left behind. And any diminished economic or political power they have just isn’t that much less than they probably have today, and they’ll have cheap everything they could want + cheap medical and mental health care.

Idk how it’s that’s different than the current situation. Imo most people work to survive and pay the bills and don’t have any political or actual economic power to do whatever they want or actually make a difference. Maybe only 0.1-1% of people actually do. Maybe I’m underestimating the importance of most labor as a participant in the economy, but imo if AI gets so good as to render even 10% of the current US or global labor force as completely useless, unnecessary, and perfectly replaceable for any existing and new job types, then I don’t think it’ll stop there and we soon get extreme material wealth and abundance for everyone. Extreme deflation, almost all goods and services that anyone would want for super cheap.

Throughout history, people worked because they needed to survive. If a technology both cures diseases and reduces the need to work, that is two positives and not one. The risk with AI is not that it would replace jobs, but that it will lead to less material welfare or political power. It doesn’t have to be this way, but is something we need to watch out for.

So is AI production defined as the full supply chain required to train AI (hardware, chips, power, land acquisition, mining) and AI research includes the software, data collection, and iterating on methods to train and orchestrating/managing the actual training runs of AI? I haven’t read the piece yet so might be a stupid question.

Recommend reading! This idea- thinking of AI production automation as a distinct milestone that will likely occur after AI R&D automation- has been really handy for me since I first heard Ajeya describe it, for thinking about where humanity will retain leverage

@inductionheads @kimmonismus Thank you! Dw about me tho, I’m doing just fine with cochlears and would be fine if they didn’t get any better the rest of my life, any upside is cherry on top! A lot of other tech to be excited about that will inevitably come anyway :)

@kylemarieb @kimmonismus I’m sure there will be lots of progress on this in the years to come. I’ll be pulling for you, best of luck

1/ Insane: A single injection into the inner ear reversed deafness in all ten patients. Some started hearing again within weeks. Gene therapy just crossed a threshold we thought was still years away. Lets dig into this breakthrough and how it works 🧵

Yes! I did some Grok research on it today, I have a different genetic cause than this, and the gene therapy for it is not as far in. Adding a lot more detail below if you’re interested: I have Pendred syndrome and because of that, enlarged vestibular aqueduct syndrome (EVA), mutation on SLC26A4 gene (found with Nucleus 30x WGS). I knew I had EVA since I was a baby but found out it was caused by Pendred last year with the WGS. I actually learned today that it’s not damaged or lost cilia that is the reason, it’s the chemical makeup of the fluid around the cochlea, it doesn’t have the right makeup of potassium and calcium so the voltages are off and the cilia can’t generate current to stimulate auditory nerve (wild shit). I got first cochlear implant at 13 months (one of the youngest at the time, FDA raised youngest age for surgery from 18 months to 12 months at the time AFAIK) and the second when I was 5, and I’m 26 now. My cilia have probably degraded a lot but maybe some stem cell therapy could rejuvenate in the future. But the gene therapy for my genetic mutation could likely be something similar to this, and it could restore the fluid balance. It won’t change the differently structured bones in my ear from EVA but that isn’t the root cause so it’s not a huge deal. In terms of a potential therapy helping, it could likely be some natural hearing back, which I would gain as an extra layer on top of my existing cochlear implant hearing. Would be very cool to try! I’d likely wait for some studies on adult outcomes and such before trying if it existed, but we’ll see. I got my first implant a week before FDA approved the model, chances are I could probably gauge if it’s worth before it’s officially approved in some regulatory capacity. Crazy times we live in! In terms of cochlear advancements, something I’m definitely watching is new high channel count photonic led versions. I currently have 24 channels/electrodes on each ear, scientists are working on a sick solution like Science Corp and Max Hodak is doing for eyes but for ears. Deliver gene edit to nerve cells in ear to be susceptible to certain wavelengths of light and then put a 10,000 channel miniled array/screen that sends that wavelength to the nerve cells to stimulate them.

@kylemarieb @kimmonismus Would you be interested in trying this?

@L0rdEnglish @donerkebab7 @djonesuk @reddit_lies @davidbombal @ThreatLocker You put your radiators facing away from the earth and away from the sun, and you can make them double sided. This is directionally a solved problem and the physics works out, it’s just an engineering problem

@donerkebab7 @djonesuk @reddit_lies @davidbombal @ThreatLocker yeah basically you end up having to only radiate away on the side in shadow, and then the sun facing side you'd put very reflective material. so half the area, but still not impossible

Why space servers FAIL Execs want to put data centers in space, but there's a massive physics problem: vacuums have no convection cooling. Discover why cooling servers in space relies purely on infrared radiation! Big thanks to @ThreatLocker for sponsoring my trip to ZTW26 and also for sponsoring this video. To start your free trial with ThreatLocker please use the following link: threatlocker.com/davidbombal

@johnwalters_sd @kimmonismus x.com/i/grok/share/3…

@kimmonismus I'm wondering what percentage of deaf people are deaf because they were born with OTOF gene mutations?

@GeneSmi96946389 Thanks for the response! Very informative

@kylemarieb And actually, even in this case I think you’d likely be better off using Herasight because they can better model disease risk when there’s a family history.

Today I'm releasing the internet’s most comprehensive guide on how to have genetically enhanced children via IVF and polygenic embryo screening.

@WLOGSarim @tszzl Obligatory

@tszzl every few years a sentence is produced that would kill a medieval peasant instantly and this is one of them

teleologically the point of ycombinator “the startup that creates more startups” was to birth openai, the dawn of the autonomous self-casting spell at the end of capitalism. so garry tan going into the ai psychosis monastery to build gstack is all part of his artform and remit

@tszzl Hang it in the Louvre

@ShakeelHashim @netcapgirl

@ShakeelHashim Additionally, it is models capable of delivering business value from insights into the company’s unstructured data

New terrible definition of superintelligence just dropped:

@Dorialexander Just gotta turn up the “RSI”, “principal SWE”, and “make no mistakes” vectors and you’re there

I like how Anthropic is just obliquely releasing their work on recursive self-improvement.

@allgarbled You just need to eat them right away

I’ve changed my mind. The in-n-out fries are actually good.

@the_P_God You mean non-reasoning LLM on the free plans?

The dumbest people you know are using a LLM to create a peptide stack

@javichisco @yacineMTB We’re gonna find the Loch Ness and Megalodon

@yacineMTB Bro an autonomous robot than can actually explore the ocean by itself and then come back with the localization/position of cool stuff would be awesome

some people on this website are genuinely insane. like just not normal at all. the level of skill is astounding

@imitationlearn @tszzl He said “technology” not models

@tszzl what diseases have models cured

crazy oai is claiming these things but sure why not man

@AutismCapital x.com/0x_lotion/stat…

Everything feels different lately. Not sure what's going on. But it feels like everyone is quiet quitting. There's an air of resignation. Vibes are really off. Communities drifting apart. Regardless, hope everyone is healthy and happy and living their joy: whatever that may be.