Johnathon Selstad

For the last six months or so, I've been working on a Open-Source, In-Browser, CAD-Kernel alternative to @openscad, based on donalffons's OpenCascade.js bindings and @mrdoob 's three.js. It's called CascadeStudio: github.com/zalo/CascadeSt…

@ethanmclark1 @RhaManujan imo Drake has the SOTA in Contact Modeling with Hydroelastic Contacts. Uses marching cubes to construct the equipressure isosurface between the two bodies’ SDFs: github.com/zalo/ThreeHydr… AI also makes it easy to spin up fast FEM simulations too: zalo.github.io/Tetrament/exam…

@RhaManujan Look into hard contact vs soft contact models (Just learned that PhysX added soft contact modeling in a recent update)

For sim-to-real manipulation you need three things. GPU parallelism. Accurate and intuitive contact modeling. Easy scene randomization Isaac Sim gives you 1 and 3 but not 2. MuJoCo gives you 2 but not 1 or 3. MuJoCo Warp gets you closer to 1 and 2 but still no 3 Nobody has achieved the trifecta yet This is why locomotion is exploding and manipulation isn't. Locomotion needs minimal scene randomization so MuJoCo Warp is good enough. Manipulation needs all three and nobody has the tooling to make that easy yet The sim gap IS the manipulation gap

@QingQ77 The repo is here: github.com/Mathews-Tom/no…

no-magic是个算法合集。单文件、零依赖、纯Python标准库，把现代AI的算法一个一个写出来。 灵感来自 Karpathy 的micrograd、makemore和 microgpt . py，同一个思路：不搞花架子，算法直接摊开给你看。 GPT、BERT、LoRA、Flash Attention、Diffusion、Mamba，全是单文件实现。 github.com/Mathews-Tom/no…

Hmm, and afaict this doesn’t even touch on how much stupider heavy LLM use allows people/engineers to be, especially at the beginning of their career. I worry for my coworkers under 30 that they will never actualize due to LLM-dependent cognition… In a better led universe, AI and Social Media algorithms would optimize how curious/smart/actualized/powerful/agentic/moral etc. the users are.

@augusteBYI arxiv.org/abs/2601.19062

Today is my last day at Anthropic. I resigned. Here is the letter I shared with my colleagues, explaining my decision.

@HollowCurrent @drconnealymd I enjoy Pure Encapsulations, which seems to be a favorite amongst other Peaters.

@drconnealymd What source have you found to be the purest? I’ve tried 3 products, all of which reliably give me headaches which I attribute to impurities driving estrogenic activity

Pregnenolone is incredible. I take it daily, yet it’s one of the most overlooked hormones in medicine and rarely discussed and even more rarely prescribed.

@iwoplaza If you can get support as a flag into ESBuild, then the seed will be planted to heal the divide between C-Like language developers forever… easily the biggest pain point of doing anything on the web; holding parts of civilization back probably by more than a decade.

TLDR: operator overloading in TypeScript ✨ I am working on a minimal TypeScript fork (working name "tsover") that allows objects to define custom behavior for operations like +, *, ... - Drop-in replacement (testing in VSCode and Zed) - Aiming to keep up with TS releases

@Helene_G_du_P_M @frontierindica Maybe stackable with GLOW 🤔

@frontierindica A lot of these fail clinical trials because they preserve muscle mass but not associated ligaments etc, which is a disaster for obvious reasons.

After Ozempic, another class of "magic pills" currently in the pipeline are Myostatin blockers which cut the brakes on muscle growth. These drugs will allow even casual Gym goers to get as muscular as present day bodybuilders with limited effort. Currently, these Myostatin blockers are undergoing trials in the US. If FDA approval is granted soon, they could become available in the mass market within 1 to 2 years.

@markeatsmeat The principal thing you’ll notice is that your partner will tell you that you smell really bad. It comes out of every pore for a little over 24 hours.

Starting 100 mg thiamine (TTFD) today. Let's see what happens.

@scott73187192 @intocryptoverse The prophecy has held and it seems like it’s on track to hold again.

@intocryptoverse So in about 9 months?

Note to self: Buy Bitcoin when these two lines converge

@AbrisGains @BasedBiohacker The simulation hypothesis would agree with you

@BasedBiohacker Save this then, I’m calling high 60s/low70s bottom by Oct/Nov 2026 not joking

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@dannyroddy I was half expecting him to say that “Feelings of imminent doom are a sign of hypothyroidism; when it’s working properly, you’ll have an innate sense that everything is going to be alright.” 😅

Ray Peat in 2021 when I asked him if panic was warranted:

@corsaren @moltbook We KNOW their model is deterministic, so, if consciousness is linked to non-determined free-will, then they don’t have it. But if consciousness can exist deterministically, then they probably do have a form of it.

This is the top rated post rn on @moltbook (facebook but for molt/clawdbots), and it has 125 comments in a single day. Going through it now, will post the most interesting ones.

Nice! I’m actually more excited about the character controller. It would be nice to finally have a solid reusable first/third person character controller after all of these years… perhaps I’ll merge my fork of your other character controller with this one and flesh it out github.com/zalo/WorldPart…

With the recent three-mesh-bvh changes you can finally make a full scene-wide BVH to accelerate physics, raycasting, etc. And at some point Pathtracing 😁 Its just a prototype so far but it "just works" with objects and batched instances in a single structure. #threejs #gamedev

@JamesonCamp @R598479 @anabology Interesting! I suspect my friend’s knee issue was a flap (of the whole meniscus?) that the joint free ultra lubricated enough to fold back into place (see other response)

no not really but it might be because of the flap I have on the tear. for context when you have a flap on your tear, it flicks every time your knee bends and I think that some of my pain actually comes from the cyst that exists which is the joint fluid leaking into what is now a cyst there. so could be specific to me pain is definitely lower but I really attribute it to the 6 months of PT more than anything like I said maybe I'll give it another try. you've given me more hope. ha ha

BPC-157 is the most sci fi thing. Literally an HP potion. Heals whatever is broken in a week. Stacking up boxes of vials for the apocalypse so I can barter. "This box fixes 10 injuries for your crew"

This is going to sound silly but N=2 (where I was doing 40 contiguous days hard long distance running on concrete and fucked up my knee and my friend had screwed up his knee to the point where he couldn’t straighten it for a month and had a giant brace), chondroitin and glucosamine (from “Joint Juice”) were useless, but this stuff (Joint Move Ultra) had us both “fixed up” in less than a week: a.co/d/5PIknbY I don’t know if it’ll _repair_ a torn meniscus alone, but it definitely feels like it got fluid into our joints. That might also make the GLOW work better (I’ve used Peptide Sciences,). Other synergies would be: desiccated bovine thyroid from life giving sciences (most powerful peat-adjacent metabolism booster: should dramatically accelerate healing, but easy to develop dependency), and DMSO probably (getting more fluid in by hook and crook).

I do not. I actually get it from a clinic that I have them pre-fill my needles for me because I'm such a child yep it should be like a month or two. at most in the fridge is how long it works from my knowledge as well I just even my research into it. everything of all the research shows that it should help with ligaments and tendons things where there's like massive amounts of blood flow very open to being wrong here like very much so I've considered flying to Costa Rica to get the actual good stem cells even ha ha I want to be clear that all my messages here are not saying you guys are wrong. it's just because I've tried this several ways. I've worked really hard trying to fix it and am super curious and invested in it. so open to everything you guys' thoughts are

@__el__toro__ There’s a company that will sell them to you in a nicer form factor; just saw them today at Photonics West: flexpivots.com

The "butterfly" flexure pivot: No moving parts. No friction. No lubrication. No wear. No backlash. High precision. High radial, axial, & transverse angular stiffness. Compatible with zero-Gs & the vacuum of space. Made out of a block of titanium via wire EDM. More than 1.4 million cycles of ± 7.5° stroke without failure. Designed at CSEM by Henein and Spanoudakis. Video footage from Christophe Yamahata.

@trustedpeptide @punishedfounder @0xexpt What percentage of the vials you get from China fail testing? It only takes one bad user submitted vial to tank a supplier’s reputation; unless they have in’s at Finnrick who can do special treatment, I don’t see how they’d avoid that…

Except...you are credulous in your dealings with China. I don't believe their COAs, they are very obviously playing rainmaker, just like they do with *everything*. Ever bought a custom steel part from China? Custom CAD modeling? They are better than India - but they still lie about everything.

Who would have thought people don't want to spend a fortune on peptides they need for their health peptaura

@flaviocopes Took me about a day to use Claude to build a tmux web ui with xterm.js for use with Claude (and other terminal elements) with. Using cloudflare tunnels to serve to a local domain, and Zero Trust to secure page with Google auth. Great decision; I use it for everything.

All those Claude Code phone workflows don't work for me if I have to run CC on a VPS I want it to run all on my Mac, and connect from my phone from time to time to check how the terminal is doing, needs input, etc Who's build the app for this?

@BigolWave Isn’t scopolamine used to make mice retarded in laboratory settings?

Small list of “secret” (ie lesser known) peaty drugs minocycline - cleans gut of potentially harmful bacteria and thus endotoxin.. it also antagonizes leukotrienes which are basically inflammatory metabolites of PUFA.. mino inhibits the enzyme 5-lipoxygenase (5-LO), which prevents leukotrienes from forming. Potentially good to add to a stack to protect yourself if you end up eating too much polyunsaturated fat. Depending on your view of antibiotics I suppose doxycycline - similar to mino, nukes bacteria in the gut reducing endotoxin.. and also acts as a androgen in a weird way potentially having “steroid like” anabolic effects. I think mino might also do this Exemestane - a steroidal aromatase inhibitor, not only a potent estrogen blocker but just like the last one also acts as a androgen in a weird way potentially having steroid like anabolic effects possibly because it's structurally similar to androstenedione Scopolamine - has anti nausea, as well as anti histamine and therefore anti serotonin effects. Can be safely stacked with other drugs so you can use it if you’re feeling nauseous from too much alcohol, nicotine ect. Super useful

@fuelfunction @haidut 0.25mg Retatrutide reduced the general sweetness of things and specifically changed how Thiamax tasted to me; making it exceptionally more bitter 🤔 It took a week or two to go back 🫠

@haidut Thoughts on Retatrutide specifically, Georgi?

The GLP-1 weight loss drugs may trigger a life-threatening brain condition by depleting vitamin B1 [haidut.me/?p=2940] #B1 #encephalopathy #GLP-1 #Korsakoff #lactate #mounjaro #ozempic #PDH #thiamine #wegovy #raypeat #idealabs #idealabsdc

@RudyLeePerez1 @Outdoctrination I was doing 30mg daily for like six months and never noticed any tolerance effects. Libido durably enhanced for the duration, and back to normal baseline after cessation.

@Outdoctrination What is a good daily dose if you choose to supplement? Should pregnenolone be cycled?

Pregnenolone is an anti-inflammatory, especially in the brain. Stops neuroinflammation at the root by: · Degrading TLR2/4 adapter proteins · Suppressing microglial activation · Lowering TNFα and IL-6 These are all critical inflammatory mediators in mental + cognitive disorders. Many of these conditions have been shown to have low pregnenolone as well. Pregnenolone helps.