Wai-Hong Tham

We are making antibody cocktails against #COVID19 !! 🙏 #MRFF funding to manufacture monoclonal antibody treatments into clinical trials. Great collaborative outcomes between @WEHI_research @TheDohertyInst @BurnetInstitute @KirbyInstitute @CSL AffinityBio and @CSIRO

We just opened 5 junior group leader positions at the Ignaz Semmelweis Institute in Vienna. We are looking for motivated, enthusiastic young leaders in infectious disease research that complement our current team. More information here: semmelweisinstitute.ac.at/training-caree…

Pleased @Sleebs_Lab contributed a small role in remarkable team led by Paola Favuzza and Alan Cowman @WEHI_research and David Olsen and John McCauley at MSD that developed MK-7602 now in clinical development for the treatment of malaria. thelancet.com/journals/ebiom…

Australia's research capability is set for a major boost, with 8 new ARC Centres of Excellence receiving $279M. From quantum computing and ocean health to renewable fuels and social inclusion, these Centres will unite leading researchers to tackle critical challenges: arc.gov.au/news-publicati…

Tomorrow (Tues 9 Dec) we will be announcing the outcomes of ARC Centres of Excellence 2026 (CE26). Stay tuned for an update.

I’ve been working with BoltzGen lately and decided to put down a short breakdown from a biologist's perspective. Full blog link in the comments

HAP2 is an ancient fusogen and used by malaria parasites for gamete fusion during fertilisation 🦟 Check out our preprint on P. falciparum HAP2 - crystal structure of domain 3 + nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚 biorxiv.org/content/10.648…

@Kev_in_Science @_fernace @Hyonxhi Just saw this today! Looks amazing

@tham_lab @_fernace @Hyonxhi Malaysian Fair at Vic Market today Damage: 3 x chix, 3 x lamb Satay = $21 1 x fruit rojak = $15 1 x scoop pi pa gao, 1 x scoop chendol = $9 1 x Ayam Masak Merah = $15 (for later) All quite good, can come down if you are around the area 😉

Introducing Dr Jaison D Sa @JaisonDSa1 who was awarded his PhD from University of Melbourne 🎉🎉 Co-supervised by Phillip Pymm & me 🩸Stabilized vivax antigen for serodiagnostics 🧬 Alpseq open source nanobody discovery 🦙Nanobodies to Plasmodium adhesins – watch this space!

Keen to use an open source workflow for nanobody discovery? Check out Alpseq 🦙 Alpseq’s diversity analysis, enrichment counts & clustering allow different approaches for nanobody selection Great collab @QGouil & Kathleen Zeglinski @WEHI_research biorxiv.org/content/10.110…

Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in @PLOSPathogens journals.plos.org/plospathogens/… Led by previous PhD student @BacchettiRoss and carried on by current PhD student, Sarah Stevens.

Learn how our hunt for the native structure of top #antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM

Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab. Germinal achieves success rates of 4-22% across diverse epitopes. We make the work fully open, without doing lame things like posting a preprint without methods. 🧵

In two weeks, the 2025 Nobel Prizes will be announced. Based on looking at other pre-Nobel “predictor” prizes, I think that these 36 scientists are the most likely candidates:

Delighted to talk about blocking malaria transmission at Director’s Seminar @JCSMR 🦟🦟🦟 Fun to discuss cryo-EM structures, nanobodies, new bispecifics and mRNA vaccines that block transmission🔬 💉 💎 🙏@MeganOutram91 for taking the first ever photo where you can see me 😂

Step inside the world of discovery, where imagination and creativity collide, with our online gallery #ArtofScience. View 16 extraordinary images captured by WEHI scientists working to solve urgent health challenges. See the exhibition: wehi.edu.au/art-of-science…

Delighted to share our review on how those malaria parasites get into our blood cells and how we might stop them. rdcu.be/eGnUl

Frankie Lyons PhD Completion Seminar 💕 She worked on key fertilisation antigens for malaria parasites - Pfs48/45 and PfHAP2 - developing nanobodies, bispecifics & mRNA vaccines to block malaria transmission 🦟 @WEHI_research 🌱 Lab support wearing her favourite moss green

🎓 Applications are now open for WEHI’s International PhD Scholar Initiative. 📅 Apply by Sunday 26 October 2025 🔗 Learn more about eligibility, scholarships and how to apply: wehi.edu.au/education/phd/… Help us spread the word by sharing with your networks!

Like to take 12–24 months of fully supported research in Japan? Early-career Australian researchers can apply for the 2026–27 JSPS Postdoctoral Fellowships to undertake 12–24 months of collaborative research in Japan. This prestigious program offers generous support, including airfares, a monthly stipend, a settling-in allowance, and overseas travel insurance. 📆 Apply by Thursday 2 October, 2025 🔗 Learn more and apply: @jsps_sns" target="_blank" rel="nofollow noopener">science.org.au/supporting-sci…

From molecular speciation of mosquitoes by PCR, to multiplexed malaria amplicon sequencing to inform public health policy, we love how our “lab in a suitcase” equipped with #BentoLab & ONT #MinION enables us to bring our science to the communities at greatest risk for malaria.