Hrishi Venkatesh

Impressive job of post-publication Twitter peer review on this paper! With the effect size appearing inexplicably massive, plus the many inconsistencies in study conduct and reporting, it’s safe to assume the “time-of-day IO” question still fully open. nature.com/articles/s4159…

What drives immunosenescence—the degradation of function our immune system with aging that increases the risk of age-related diseases? Today @SciImmunology the B cells are identified as the bad actors because they induce T cell (CD4) dysfunction and inflammaging (work in experimental model). When B cells are eliminated, healthspan improves. science.org/doi/10.1126/sc…

Byrne’s group (Cancer Immunology Research) shows CD4⁺ T cells mediate rejection of MHC-deficient pancreatic tumors after anti-CD40 + dual ICB. CD4 (not CD8)T cells drive it, reprogramming MHCII⁺ stromal & endothelial cells for tumor control. …rjournals-org.proxy.library.emory.edu/cancerimmunolr…

What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. biorxiv.org/content/10.110…

Excited to share our review with @lawfong on CD4+ T cell dysfunction in cancer! We highlight the diverse functional states of CD4+ T cells throughout their differentiation — from priming in tumor-draining lymph nodes to terminal differentiation in tumors. rupress.org/jem/article/22…

@DelgoffeLab Congratulations!

Honored to be elected and excited to help support the future of cancer immunology!

Interesting!

Whether you're riding with us, donating, or joining our fun games — you’re part of the cure! Thanks!

You can also support our cause by donating here: secure.fredhutch.org/site/TR?team_i…

The Fong Lab at Fred Hutch is excited to join Obliteride 2025 to raise funds for life-changing cancer immunotherapy research!

This month, the Big Ten Cancer Research Consortium highlights our member institution @fredhutch Cancer Center and Lawrence Fong, MD, who serves as scientific director of the Immunotherapy Integrated Research Center at Fred Hutch. Read more: bigtencrc.org/member-feature…

@aaronmring @Yile_Dai @Nature @fredhutch @FH_IRC @YaleCancer @YaleIBIO @Seranova Congratulations!

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…

A landmark study published in @Nature by @aaronmring et al. has revealed that autoantibodies — immune proteins traditionally associated with autoimmune disease — may profoundly influence how cancer patients respond to immunotherapy. bit.ly/4o4HANS

In my view, the question of T helper cell differentiation should be divided into: (A) stochastic phenotype acquisition by naïve T cells via innate signals, and (B) pathological responses from cross-reactive, pre-existing memory T cells. #immunology cell.com/trends/cell-bi…

CINTER-seq enables in situ capture and multimodal profiling of interacting cells in living mice, uncovering specific LAG3-MHC II-mediated CD4+ T cell-cancer cell interactions & tumor-reprogrammed neutrophils cell.com/immunity/fullt… @ImmunityCP

@NNJarjourPhD @VersitiResearch @MedicalCollege @childrenswi Congratulations @NNJarjourPhD! 👏🎊🍾🍾

Absolutely delighted to announce I’ll be opening my lab next month @VersitiResearch in Milwaukee! Grateful for an outstanding home for the group and for great new colleagues at Versiti, @MedicalCollege, and @childrenswi who have been so welcoming! We’ll be hiring soon

@OveracreLab Congratulations! 🎊

First paper ACCEPTED from the lab! More details coming soon—until then, time to celebrate!

A really important work by @MaxKrummel and colleagues highlighting key differences in the immune cell composition/interactions in tumors between mice and humans.

@IngunnStromnes Wow congratulations Zoe!

Wow! We are crazy proud of Zoe Schmiechen for winning not 1, not 2, but three trainee awards this semester! Zoe was the recipient of the Milne/Brandenburg, J. Kaplan, and Bacaner awards. Thank you to all the committees who independently recognized Zoe's excellent research!