Joseph รีทวีตแล้ว
Joseph
1.6K posts
@namimzz @cremieuxrecueil technically correct 25% of China's output to match total beef co2, but regarded for not getting the point. It's not a problem or a solution.
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@wethebots_ @cremieuxrecueil Lets take your number. That is still more than 10% of what China emmits
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Another example of the fact that, unless you're willing to make life unbearable, reducing consumption is not the solution to climate change.
Mario Nawfal@MarioNawfal
🇩🇰 Copenhagen's Green-led council is limiting elderly care residents to 80 grams of beef per week for climate reasons. That works out to 11.4 grams a day, which is less meat than most people put in a single taco. A Green party rep explained the logic: the elderly "have been the biggest climate sinners throughout their lives." So the plan is apparently to make them atone for it in their final years, one thimble of mince at a time. Critics, including opposition parties and elderly advocates, say the policy risks undernutrition in a population already vulnerable to it. The council says it's flexible, but the elderly eating climate penance for dinner might disagree. Source: BT, Ekstra Bladet
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@bryan_johnson Dang all it took for a billionaire to understand the struggle of the commons was DMT
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Society was built to make money.
Indifferent to your health and sanity.
For example, we did not evolve to:
+ sit 10 hours a day
+ have our attention fractured 300 times daily
+ compare ourselves to millions of others
+ travel 9 time zones in 13 hours
+ tolerate sounds above 85 dB causing hearing loss
+ outsmart algorithms hijacking our reward system
+ breathe fine particulate air pollution
+ live under 16+ hrs of artificial light a day
+ have 3 courses of antibiotics before age 2
+ eat ultra-processed foods for 60% of daily calories
+ consume 17 teaspoons of added sugar a day
So if you're feeling down in the dumps, maybe fatigued, a little or a lot depressed, anxious, that's why.
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I keep seeing this study being posted - the important point being that the patients in this study were all diabetics and the comparison was between those on GLP1 or on SGLT2i drugs.
For non-diabetics not on other meds, this study is much more applicable, in which they found no increased risk of NAION compared to placebo in both diabetics and non-diabetics:
bjo.bmj.com/content/early/…
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GLP-1 drugs are associated with a 35% higher risk of NAION, an eye condition that can cause sudden vision loss.
About 6 to 10 extra cases per 10,000 users over 3 years.
The association is specific to NAION. No other eye conditions were affected.
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Seeking comfort & satiety is the fastest way to the grave
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@agingroy as a preventative intervention it should definitely show a strong benefit, you don't cure Alzheimer's you prevent it. Curing Alzheimer's would be equivalent to turning back time if they ever find that it won't just apply to the brain it would apply to every other organ.
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Both GLP-1 drugs failed to treat Alzheimer's. But one left a strange clue.
Liraglutide. 204 patients. Primary endpoint: missed. But on an unpowered, unplanned MRI measure, brain atrophy was roughly 50% less than placebo.
Semaglutide. Thousands of patients. EVOKE and EVOKE+: negative on every cognitive measure.
Same receptor. Both reach the brain. Nobody can explain the divergence.
15 million people take GLP-1 drugs. Neither one is an Alzheimer's treatment. Not yet. Maybe not ever.
Published in @NatureMedicine and @TheLancet. Both @NovoNordisk
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We need a slur for people who think AI is conscious.
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Astaxanthin was tested for lifespan in mice.
In 2023, it increased lifespan by ~12% in male mice
But a new 2026 study found no effect.
The big difference: dose and timing.
Full video breakdown: youtu.be/ZTwlmD2BqpY
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@Aella_Girl As birth order increases so does the age of the father, Y chromosome bearing sperm are generally more susceptible to damage since only a single copy of Y chromosome exists. Physically and mentally stressed out fathers are more likely to have females.
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@Tetrahydropyran @cremieuxrecueil yes it's obvious that glp-1r are protective vs non treated diabetes group, both groups are diabetics.
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@cremieuxrecueil I wonder what would happen if we compared GLP-1R with metformin or DPP4i. How can we know SGLT2i don't protect against NAION? They help heart failure and CKD.
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The latest GLP-1RA NAION analysis is a cohort study comparing diabetics on GLP-1RAs to those who use SGLT2is.
It found about 8 extra cases per 10,000 users.
And it also found literally nothing for any other vision-related outcome.
Crémieux@cremieuxrecueil
New GLP-1RA NAION analysis: Across trials, there have been three cases among GLP-1RA users and five among placebo users. In other words, there's no evidence of any elevation of risk from using GLP-1RAs. The hype given to these unreal side effects will hopefully die soon.
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@cremieuxrecueil baseline bmi of the groups normalized the difference in cases, there is not true risk increase.
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Why we think this is real, not a fluke.
Two alternative explanations to rule out:
1. People on GLP-1 drugs may see eye doctors more often and pick up incidental diagnoses.
2. GLP-1 drugs may cause general eye problems, with NAION just one of them.
We checked. Neither held up.
▸ Diabetic retinopathy: no difference
▸ Macular degeneration: no difference
▸ Retinal vascular occlusion: no difference
▸ Optic neuritis: no difference
▸ Eye-care visits: similar in both groups
The signal is specific to NAION.
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Do GLP-1 drugs increase the risk of vision loss?
Specifically, a condition called NAION: a sudden loss of blood flow to the optic nerve that can cause vision loss.
We looked at this in 588,000 people.
The answer, in our new @JAMANetworkOpen paper, is yes. 🧵
jamanetwork.com/journals/jaman…
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@agingroy dapagliflozin is now $15 for 90 days on marc Cuban pharmacy, the sample size of the study was too small plenty of treatment group shortened telomeres. The mechanism of action is removal of senescent cells leading to a greater average telomere in white blood cells.
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First drug ever shown to lengthen telomeres in a randomized trial.
Henagliflozin, a diabetes drug, for 26 weeks.
Results:
- Treatment group: 90.5% had longer telomeres
- Placebo group: 65.6%
- Difference: statistically significant, p<0.01
This isn't a supplement study with 12 people. It's a randomized placebo-controlled trial of a drug millions already take for blood sugar.
Telomere shortening is one of the 12 hallmarks of aging. Every decade, your telomeres lose about 14% of their length. This is the first time a pill has reversed that trajectory in a controlled experiment.
SGLT2 inhibitors already extend life in heart failure patients. Now we might know one reason why.
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