Steven Collard

The beginner phase is dangerous You think you understand You don’t even see what you don’t know

@jimcramer feels like catching a falling knife though

Very oversold...

@SpaceX @Starlink how heavy is one starlink satellite?

Falcon 9 launches 29 @Starlink satellites from Florida

@garrytan start by tasting things you hate twice

How to develop taste

@JossSheldon someone's really going for the full dystopian bingo card

Ever feel the need to rebel? + Secret Courts + Snoopers Charter + Trident renewal + Scrapping the Human Rights Act 📒 amazon.com/Little-Voice-E…

@BorisBerenberg how often do you get legendary cities?

When I get a legendary city on Conductor I feel like it's a bit sad to use it for just a small docs fix. Do I re-use the workspace? These are the difficult questions we must grapple with in the arena.

@pmarca building th matrix but cooler

It’s time to build the Independent AI Grid.

@TurnerNovak the paperwork alone would break me

Imagine raising a triple-layered SPV for this 😍 😍

@TiffanyFong higgsfield sounds like physics magic

@andrewchen how much supply can realistically flip?

marketplace startups are destined to be massively reinvented by AI. The weak form is already happening, where we use LLMs for customer support, supply/demand matching, etc. That’s easy The strong form is to figure out how much of the supply side of the marketplace can be turned agentic and ultimately, robotic. “Uber for X” will have consumers requesting robots to do X. Every on-demand service of the 2010s will instruct a robotaxi or delivery robot. Or if you’re prev used a marketplace to hire X, then you “hire” an agent instead. You won’t need to app developer, because there’s agents to build your app This will impact marketplace cos differently. Of course some marketplaces - like Airbnb - inherently work in the physical and will leverage AI around the core value prop. And some are bound to lose their network effects as matching fragmented supply/demand turns into an AI problem. Much change is coming The next big business model for marketplaces will emerge when demand works at high abstractions and supply meets it by becoming programmable

@craigzLiszt teaching the cat first was smart they learn fastest

我已经开始让老婆、孩子和猫学中文了，以防万一

@nntaleb makes sense why carthage became so different

A central point is that Phoenician city states were not interested in war and domination via land control; with the exception of Carthage, they just wanted commerce.

@NWischoff jealous of your hill valley lineup

Hill & Valley next week. One of my favorite events. Let me know if you're in town!

@ellen_in_sf where is hq located?

bringing vibes to the mem0 HQ

@alexisohanian @PlayGOALS numbers going brrrr mode already

Feeling good! @PlayGOALS engagement metrics coming out strong early

@martin_casado which auth provider did you pick?

Nice. The agent stack is coming together ... compute, filesystem, now auth ...

@Suhail I feel you

@Suhail @bchesky someone's accountant is having a very confusing day

@bchesky Their raise was our post valuation 😭

After YC, Airbnb raised $615k at a $3M post-money valuation. We were the highest valuation in our batch.

@Suhail that 500k must have felt massive

@bryan_johnson went from olympic swimmer sperm to just varsity level

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

@shadcn black on black chef kiss

This also means you can go full monochromatic.