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7K posts
@ifixhearts My triglycerides are 49, HDL is 71. I think that’s really good, right?
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The ratio between your triglycerides and your HDL is a very good predictor of metabolic health.
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@GarryPNolan @TkMe2UrLeader11 Please have a podcast with @drmichaellevin . Two geniuses in their fields
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It could also be that the rare-earth peaks are misassigned diatomic or triatomic ions. These are cases where atoms combine after vaporization, sputtering, or ion formation and then appear at the same nominal mass-to-charge ratio as heavier elemental ions.
For example, a silicon dimer composed of two 28Si atoms has an exact mass of 55.9539 u (28Si + 28Si = 27.9769 + 27.9769 = 55.9538 u; more precisely 55.9539 u depending on rounding), so in the singly charged state it appears at m/z 55.9539. That would resemble Iron (56); it is much closer to ions near nominal mass 56.
By comparison, 54Fe is 53.9396 u, 56Fe is 55.9349 u, and 56FeH is 56.9427 u. A Si dimer containing one 28Si and one 29Si would appear at 56.9508 u, and 29Si-29Si at 57.9477 u. Thus, dimers can overlap heavier elemental peaks if the instrument lacks sufficient mass resolving power to separate differences at the third or fourth decimal place.
Charge state also shifts the observed m/z. A doubly charged ion appears at half its mass-to-charge value. Thus, monatomic 28Si2+ appears at m/z 13.9885, not at 28. Likewise, 28Si22+ appears at m/z 27.9769. This is why multiply-charged ions can be mistaken for lighter singly charged species if the charge state is not recognized. For reference, 14N+ appears at 14.0031, 28Si2+ at 13.9885, and 28Si+ at 27.9769.
For instance, Al272+ might be mistaken for iron 54. At nominal mass 54, the main elemental isotopes are:
^54Fe = 53.9396
^54Cr = 53.9389
^54Xe = 53.9396
Other possible assignments near m/z 54:
^27Al2^+ = 53.9631
One way to look for this is decimal accuracy. The other is ratios of the expected isotope distribution. If the distribution is off, it doesn't necessarily mean the isotope ratios are "unearthly" —you have to double-check for diatomic or doubly charged ions. There are many cross-checks needed.
So, accuracy to the 2nd, or even 4th, decimal place is key. Since the masses are not included in the report, one must be careful, and the data must include nominal controls.
There are ways to correct this, especially in SIMS, including isotope-pattern checks, charge-state analysis, expected molecular-ion chemistry, and use of instruments with sufficient resolving power to distinguish exact masses to the third or fourth decimal place.
Also, many "pure" materials contain various other elements.
Not opining on the conclusions, just pointing out there are always caveats to be considered.
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The Buga Sphere looks to be a terrestrial cast aluminum alloy from the 3xx.x series (Al-Si-Cu) or 2xx.x series (Al-Cu), specifically a recycled or modified version with mischmetal (rare-earth) micro-additions.
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Heart disease kills 9 million people annually. We blame cholesterol. We should be blaming sugar. Every time blood glucose spikes, glucose molecules bind to proteins and lipids through a process called glycation — hardening arteries, stiffening tissue, and igniting chronic inflammation that quietly destroys the cardiovascular system.
The heart doesn't fail because of fat. It fails because of a metabolic environment we created — one meal at a time. Fix the glucose. Fix the fire.
#MetabolicHealth #InsulinResistance #Inflammation #Glycation #Longevity
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Have you ever added a router or access point to a network ? The second you turn it on, it starts getting lit up. Hopefully uou change the PW and configure it properly
This is exactly how agents will try to sell you things.
The minute you light up an agent and the .md file is available to be read, it is going to be lit up non stop. Agents trying to take advantage of EVERYTHING.
Agents are going to be easy to set up, hard for individuals to use correctly in a Wild Wild West Agent world.
Thoughts ?
J@thelastgypsy
@mcuban Mark the issue isn't does Temu beat Amazon by ten cents. The issue is advertising. Susan goes to to buy a new dress, sees an ad for that matress she considered two months ago and buys it. Bots bypass all ads and thus Amazon hates them. Am I wrong?
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@ScottAppliedSci SGLT2 for $50/month is vastly superior in every way. Statins substantially increase risk of diabetes and they’re expensive @mcuban
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Last comment on statins for a while. It's peculiar how one of the safest drugs we have for one of the most common deadly conditions arouses such emotion and vitriol?
I used to be one of the hecklers, too. What fixed me was reading primary sources, not grifters selling something.
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This reads to me like the regional states see the continuation of the regional war, the near certainty of economic recession (maybe eventually depression), new waves of refugees, and an angering of their population as better for their interests than angering the US.
The interests of these states, all but one autocratic, is in preservation of its rulers, their privilege and the continued aid and support of the US. They often see only in the short term and mistake agreement and obeisance of the US as partnership.
To them, continuance of the war brings risk, but disagreement and rejection of the US brings certain damage and likely demise.
For most, they individually are too scared to make any decisions that would affect a relationship with the US, getting close to a century long, that ensures their own hold on power. Together, there is no trust among them to break from the American Empire as a group.
It’s hard for me to understand their shortsightedness and reckless assumption of the risk of this war other than that.
If you have an explanation to help me understand, please share.
Ragıp Soylu@ragipsoylu
It appears Egypt, Saudi Arabia, Turkey, UAE, Azerbaijan, Pakistan, Qatar, Kuwait, Lebanon, Jordan, Syria convened in Riyadh to condemn Iran, and they only briefly mentioned about Israel to criticize its actions in Lebanon, not in Tehran.
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@MatthewPHoh @HuntClancy @ShawnRyanShow please have @MatthewPHoh on your show. Tremendous integrity and courage
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no one fucking resigned over the war in Afghanistan during that entire 19 year clusterfuck except for a principled state department official who’d been a marine in Iraq @MatthewPHoh and he’s my friend and the Obama administration came after him with every dirty trick in the book
Stephen Wertheim@stephenwertheim
I suspect that so few senior foreign policy officials resign today because they fear they'll be shunned by their own political party while still being condemned by the other side. Perhaps our system will work better if we focus on the rightness of the resignation itself rather than our disagreements with the rest of the political views of the resignee.
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@MalcolmNance There’s no way to protect ships in the SOH from drones, unmanned subs or antiship missiles. Therefore, none will be doing minesweeping any time soon @nntaleb @EdwardGLuce
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NGL our LCS mine hunters are presently in Asia. Not Persian Gulf where they left from two weeks ago.
So we officially have ZERO minesweeping vessels in the PG region.
I don’t care how good your tech is, if you have to sail for 10 days to get back to the SOH you are not even in the war.
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@mercoglianos @US5thFleet @CENTCOM @USNavy @DeptofWar There are 0 navy ships within 300 miles of the Strait and for good reason @EdwardGLuce @nntaleb
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Just to be clear, the @US5thFleet has a plan to conduct this operation.
It has been wargamed and studied repeatedly.
All it requires is the execute order, but the lack of this, or any statement is not a good look for @CENTCOM @USNavy or @DeptofWar.
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RFK Jr is trying to get 14 peptides, without data on safety or efficacy, licensed and approved by FDA. His favorite is BPC-157.
"Only three small human studies of BPC-157 exist, for instance, the largest of which is a telephone survey of 16 people who received an injection of the drug for knee pain, and which was published in a third-tier journal, Alternative Therapies."
economist.com/science-and-te…
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@Retardutide @DocAbirHealth Stop eating simple carbs and sugar/alcohol. Your triglycerides:HDL ratio puts you at high heart attack risk. What’s your A1c?
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@DocAbirHealth Doc my lipids are high after 2 months of tirz. LLM says its due to the free fatty acids now circulating in my blood.
What should I do? Should I be concerned or ride the wave. I'm 28 dont wanna get on statins, maybe microdose a statin?
@DocAbirHealth
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The first GLP1 was licensed in 2005 so we have been using them for over 20 years.
The first one licensed specifically for weight loss was in 2014
Ozempic/semaglutide came out in 2021
Zepbound/tirzepatide came out in 2023
Both are FDA approved.
Retatrutide the triple agonist is still in trials. Will be licensed either late this year or likely 2027 imo.
You can stop taking anytime however you can experience rebound hunger. My advice is always to reverse taper off the same way you taper up in the beginning.
The longer you have been on them, the longer the reverse taper should be.
Side effects vary as tirzepatide and reta are dual and triple agonists so not just GLP1 but GIP and glucagon.
Common S/Es are usually GI related: nausea, bloating, abdominal pain/dicomfort, vomiting, constipation, diarrhoea, heartburn, burping etc. all the things you would expect from something that slows your gut.
Less common but more serious side effects can include pancreatitis or gallbladder issues, thought to be due to rapid weight loss and changes to bile flow.
Reta can also cause effects like increased RHR, skin sensitivity, sleep disturbance.
TheBobFather@PapaMooseBear
Yes, I could google. But asking here anyway for the conversation. How long as GLP1 been out post testing? Is it certified by the FDA etc? (Not sure I even trust them tbh) Can you stop taking it at any time? What, if any, are the negative side affects? Thanks, if you respond.
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Too many who should know better are backing this war. It wouldn't be happening if a) Trump were a remotely serious president who knew risks of embarking on something whose aims he still can't specify, and b) Netanyahu wasn't embracing chaos as his get out of jail free card.
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@RBehiel @allTheYud @x0rz worst case scenario is all your wifi-connected computer appliances get hacked and used to DDOS your smart car so you can’t drive anywhere and your fridge warms up to 80F @matthew_d_green @mer__edith
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@allTheYud The worst case AI scenario is the creation of trillions of sentient beings, forever confined to dishwashers and such.
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imagine putting an LLM in your dishwasher so it can send you notifications about how it is bored and lonely. don't know why anyone would do this tbc, it just seems like the sort of thing somebody will be determined to do
Kurt Schrader@kurt
What, in the actual fuck, kind of notification is this?
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This scene from The Midnight Gospel 💔
cinesthetic.@TheCinesthetic
What scene broke your heart to pieces?
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@DrGrimmMD @SabinehazanMD @Progenabiome @sferaadonis1 @LetsTalkSht Have you and @drmichaellevin talked on a podcast? Seems powerful
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A virus editing a bacterium that then edits the mucosa PHYSICALLY AND BIOPHOTONICALLY. That’s multiple Field layers of signaling . Ecology at its finest.
I do like the bifidophage angle & it is fascinating. If we’re perturbing Bifidobacteria at the phage level, we may not just be shifting those species #. I assume we are shifting acetate production, mucin integrity, epithelial voltage gradients, even immune tone.
One thought…this gut epithelium carries an actual measurable voltage differences across it right? Becker wrote about those DC injury currents actually guiding tissue behavior. If the virome alters microbial redox output and biophotons, could that slowly reshape the electrical landscape colonocytes sit in before dysplasia ever appears? You bet it does. That’s part of the idea behind bacterial induced constipation. Sulfur anyone???
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Yes @DrGrimmMD welcome to the work of @Progenabiome … Go to publications especially ones with @sferaadonis1 and understand Bacteriophage and bifidophage. Remember @LetsTalkSht book said it all and #SAVETHEBIF
Brian Grimm, M.D.@DrGrimmMD
This one’s interesting. A virus. Inside a bacteria. Inside you. Little creepy for sure. @SabinehazanMD will like this one. What the heck is a Bacteriophage???A virus that infects bacteria, associated with colorectal cancer?? That should make us pause for a second. We have known for decades that Human papillomavirus drives cervical cancer. We screen for it. We vaccinate against it. We accept that infection can shift cellular behavior toward malignancy. Now we’re staring at the colon and asking a similar question. Phages. They are like little architects in a way And these things are not rare. They outnumber bacteria on Earth. In your colon right now, trillions of them are editing bacterial genomes, switching genes on and off, transferring virulence factors, altering toxin production. Changing the field environment. They don’t infect you directly. They infect your microbes. And your microbes shape your immune tone, redox environment, bile acid metabolism, short chain fatty acids, epithelial barrier integrity, etc. So when a phage alters a bacterial strain, it is not trivial. It is rewriting the field the colonocytes live in. That’s not crazy mysticism from some witch doctor in New Orleans. That’s ecology in action Colorectal cancer has long been linked to dysbiosis. Certain strains like Fusobacterium nucleatum have been associated with tumor tissue. Now imagine this: What if the real story is not just the bacteria, but the viral software running inside the bacteria? This is when your head explodes LOL A phage can: • Increase bacterial adhesion to mucosa • Increase inflammatory signaling • Modify toxin production • Alter metabolic outputs That shifts OUR local ROS. That shifts mitochondrial stress in colonocytes. That shifts THE BODIES EFFICIENCY IN immune surveillance. Small perturbations. Over years. That’s how fields drift. Here’s my Field Medicine Lens …zoom out, this fits a bigger pattern. Cervical cancer and HPV. Liver cancer and hepatitis viruses. Now colon cancer and potentially phage-modified microbes. Cancer begins to look less like random mutation and more like long-term signal distortion. Put the nuclear gene to aside for a second. In the gut that signal includes: • Microbial metabolites • Photonic exposure history through the retina shaping systemic immunity • Circadian timing of epithelial repair • Redox gradients across the mucosal barrier • Bile acids interacting with microbial communities You ***change the microbial virome, you change the chemical and electrical landscape the colon epithelium sits in. *** And colonocytes are highly metabolic. Rapid turnover. Tight mitochondrial control. High need for structured intracellular water and intact membrane voltage. Disrupt that long enough and the repair programs get sloppy. Here’s the Question Are we going to start thinking about cancer risk not just as “bad cells” and “bad genetics,” but as: Who’s infecting your microbes? What genes are being switched on in your gut ecosystem? What light environment shaped your immune tolerance? What redox tone does your colon live in daily? Because if a virus inside a bacterium can nudge the system toward malignancy, ***then the battlefield is bigger than we thought *** And it means prevention might not just be colonoscopies and fiber as my G.I. colleagues like to suggest It might involve circadian repair, microbial ecology, field coherence, and understanding that viruses don’t always attack us directly. Sometimes they edit our neighbors. I think this line of research is going to get louder. And I think as doctors we should be paying attention early. What do you think? Are we ready to talk about the gut virome the same way we talk about HPV? It’s not just a Bacteroides Fragilis question anymore
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A chicken entree for $40! A chicken entree for $50!?! A chicken entree for $52!!!! What the hell is going on? To answer that question, I ate the pricey chicken at trendy NYC restaurants (I know, tough work) and talked to the people who raise, cook and serve that chicken. This poultry-palooza, for T Magazine, is the result. nytimes.com/2026/02/16/t-m…
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@FrankBruni Great job on this article. Thoroughly researched. A Costco rotisserie chicken is $5.
A 14 week pastured freedom ranger chicken without corn or soy feed costs 12 times as much, uncooked. Omega 3 amounts are radically different
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@MarkSZaidEsq Have these government lawyers not studied what happened in the Nixon era with Dean and Mitchell, etc?
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The govt lawyers who espouse position that president is their actual client will discover their legal careers will not be what they hoped for.
This is not how US constituional system has ever operated. Do they think all the lawyers in past 250 years simply didn't understand?
Ben Penn@benjaminpenn
Check out my profile of Aakash Singh, the 33-year-old DOJ bro who relishes clamping down on top prosecutors' autonomy, warning them Trump is their 'chief client' news.bloomberglaw.com/us-law-week/in…
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