Catherine Phelps

I am BEYOND excited to share my PhD thesis research is officially published in @CellCellPress today. Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃‍♀️🦠 authors.elsevier.com/c/1lPCrL7PXuFJv

Catherine Phelps from @upmc.com representing #SITC Talks on how #exercise can improve outcome - role for #microbial #metabolite #formate on mediating #anticancer #immunity / #WIC2025 #SITC2025

Talking about 3D chromatin and T cell exhaustion at #TRCCC2024

Yet another reason to exercise! Phelps et al. doi.org/10.1016/j.cell…

It’s dangerous to go alone! Take this!

Anyway, here’s Wonderwall

He’s on vacation

Online now: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity dlvr.it/TM3NYq

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity @ImmunityCP @surya25_pandey @YinanGong @RH_Laboratory cell.com/immunity/fullt…

A potent bacterium in the human gut can supercharge the effects of some cancer drugs go.nature.com/4lDfxU8

#MicrobiotaPower & #Exercise! Phelps, Meisel &co show @CellCellPress that exercise drives formate from microbiota that in turns activates NRF2 in CD8 T cells driving STAT1/IRF8 programs that potentiate immune checkpoint inhibitor efficacy against melanoma dlvr.it/TLqLW7

AAI Members in the News! For her graduate thesis with Dr. Marlies Meisel at @Pitt_Medicine, @CatMPhelps found that #exercise improved #cancer outcomes and enhanced responses to #immunotherapy in mice by reshaping the gut #microbiome. Congrats! 🔗 ow.ly/RIMj50WnXoy

🏃‍♂️💥 Exercise boosts immunotherapy! New study shows exercise increases gut microbiota-derived formate, enhancing CD8+ T cell–mediated antitumor immunity via Nrf2. ⭐️Formate may be a new biomarker for better ICI response in melanoma. @CellPressNews @OncoAlert #microbiome #cancer #Oncology doi.org/10.1016/j.cell…

#ScienceSaturday 🏃‍♂️🧬 Can exercise really help fight #cancer? 📢 A new study in @CellCellPress shows exercise rewires the gut #microbiome to enhance immune responses against tumors. ➡️ @CatMPhelps et al. found exercise increases levels of a microbiota-derived metabolite called formate, which boosts CD8 T cell function through the Nrf2 pathway. This strengthens the immune system’s ability to attack tumors, even those resistant to immune checkpoint inhibitors. ➡️ In #melanoma models, both exercise and formate supplementation reduced tumor growth, increased survival and amplified the effects of immunotherapy. High-formate-producing human microbiota showed similar antitumor effects in preclinical studies. 💡 These findings suggest a powerful link between movement, metabolism, and immune activation. 🔗 Read the full article in Cell: cell.com/cell/fulltext/… @PittTweet @Pitt_PMI

True academic friendship is agreeing to sit in the audience for their 8:15am presentation

Me right before a deadline

Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate go.nature.com/44jPqvg

New University of Pittsburgh research shows gut bacteria are responsible for how exercise boosts cancer treatment in mice, pointing to possible future therapies for humans. explorevenango.com/state-news/202…

Nice thread showing highlights of our study:

🔥HOT 2025 DISCOVERY! Original post @EricTopol CELL.com July 2025 💪Exercise could SAVE lives by supercharging melanoma immunotherapy via gut microbiome! 🪂Dive into our MUST-SEE Exclusive Video Link: oncologytube.com/2025-melanoma-… #MelanomaHope #ExerciseRevolution #GutPower @CellCellPress @sumersethi @hkanji @vankapro @kidsgastrodoc @mairal @DrSunitKSingh @Prof_NickTalley @DrRobertGlatter @MatCMeier @renesugar @SchezBorrego @P1231032850 @Bosphiz @DrJohanLim @RoryEvergrowth @CreativoEnfocad @MaggyLizaola @anaiscamacho @cinthiavgauna @HendryVictoria @xixedhellonja @NovateurBio @giorg_kyriakos @nuuuukkkkk @OscarTahuahua @cihan390 @FloraFromDaRock @ForYetBetterSci @leonardopviana @EdAlvarezB @SaubashyaSur @CrypvizerGolin @HTX_Cisco @EduardoSuarez25 @LorenaShaw @JasmineSukumar @Vic_Bioinfo @UofLEnvirome @vhugo8762 @MatSaubade @DanijelaGasevic @MPH_Stone @wot_mikey @gnomikos1 @Shell_Bell1957 @PittDeptofMed @CatMPhelps

New University of Pittsburgh research shows gut bacteria are responsible for how exercise boosts cancer treatment in mice, pointing to possible future therapies for humans. exploreclarion.com/state-news/202…