Jon Cunningham

Can AI automate HF adjudication in global clinical trials? Our latest #AHA2024 SimPub @CircHF In the DELIVER trial, our AI model for HF hosp was -Accurate -Generated identical treatment estimate for dapa as human CEC -Extracts evidence of HF Paper: twtr.to/7qxb_

@samalsabtiDO @ankeetbhatt @JCardFail @NirUrielMD @elenadonaldMD @robmentz @dranulala @AndrewJSauer @tremartyn @JavedButler1 @MarcBonaca @AJBloodMD @rohan_khera @David_Ouyang We are looking forward to it, @samalsabtiDO !

@ankeetbhatt @JCardFail @JonWCunningham @NirUrielMD @elenadonaldMD @robmentz @dranulala @AndrewJSauer @tremartyn @JavedButler1 @MarcBonaca @AJBloodMD @rohan_khera @David_Ouyang Working on a submission now. Real world echo utilization QI data as a backdrop for how AI-powered clinical reasoning tools can improve practice patterns and address guideline nonadherence in HF care. Bookmarked!

#AI is redefining HF care delivery, but this is the tip of the iceberg. Excited to share this🌟Call for Papers🌟for @JCardFail Special Focus Issue on AI + HF. Thrilled to Guest Edit w/ @JonWCunningham @NirUrielMD @elenadonaldMD! Submit by May 10, 2026! hfsa.org/journal-cardia…

Not All Hospitalized Heart Failure Patients Are the Same: A New Worldview jacc.org/doi/10.1016/j.… @JACCJournals

@CVCTForum is the best scientific meeting I have attended 🙌🏻 thanks @ZannadFaiez for the invitation! Great to catch up with @scottdsolomon & entourage Team #STRONG@HOME was well represented 😁- and the trial was highly relevant as digital care/ AI in CRM was the main topic

Thanks to hosts @DrMerkely & @KosztinMd for inviting me to speak at the Semmelweis University Symposium in Budapest on AI in cardiovascular care Enjoyed speaking with members of the Hungarian cardiology community and global colleagues like @NirUrielMD Photo @LuHenri8

Honored to present our work using ECG-AI to predict adjudicated cardiac arrest as featured science #AHA25 @MGHHeartHealth @MGBResearchNews @broadinstitute @broad_ml4h

Grateful our extended team @scottdsolomon @akshaydesaimd @SBadrouchi @patrick_ellinor @JenHoCardiology @broad_ml4h @MGBResearchNews @hfcollaboratory @coconnormd @lamcardio @hmkyale

Out today in @JACCJournals & #AHA25, led by @PabloMikiMarti Auto-MACE: automated AI adjudication model for MACE (CV death, MI, & stroke) Strong agreement with CEC in PARADISE-MI trial. Recognizes uncertain events. tinyurl.com/3w33dyec

Celebrating Women in Cardiology at AHA 2025 ❤️ An inspiring afternoon at @AHAScience #WIC Luncheon, where leaders, mentors, and future changemakers came together to celebrate excellence and equity in our field.

Doubleheader week for all-star nephrologist and mentee @SBadrouchi Spreading the word about improving CKM clinical trials with AI #KidneyWk: Generative AI for Event Adjudication #AHA25: Extracting individual symptoms, signs, and treatment from unstructured medical records

📢 Time for one of our most anticipated meetings of the year! Novel Statistical Concepts for HF Drug and Device Development Join us on November 14, 2025 | 8:45 a.m - 12:30 p.m. ET via Zoom Open to all — no HFC membership required Register here: hfcollaboratory.com/meetings/novel…

🚨 New in @CircAHA : Maternal CVD and pregnancy-related CV complications are rising sharply over 2 decades across >56K pregnancies across @MassGenBrigham. Pregnancy is a critical window for lifelong heart health! 🔗doi.org/10.1161/CIRCUL… @MGBResearchNews #CardioObstetrics

📢Personal update! ✨Thrilled to share that I’ll be moving my clinical practice to @BrighamWomens as Director of Women’s Heart Health. So grateful to my many mentors, colleagues & friends 🙏. Excited for this next chapter working to advance women’s 🫀 health! @MGBWomenHeart

Flu causes major illness and death, but vaccination rates are falling. A large trial found that cardiovascular-focused nudges did not increase vaccination rates. In an accompanying editorial, the authors contextualize the findings. eviden.cc/3JFgTiW

🚨 An extraordinary achievement from all the @CTCPR_ researchers at ESC! Our researchers simultaneously published 13 papers across leading journals, showcasing some of the latest breakthroughs in cardiology. These publications include: · 3 in The New England Journal of Medicine · 1 in The Lancet · 1 in JAMA · 2 in European Heart Journal · 3 in Journal of the American College of Cardiology · 1 in JAMA Cardiology · 1 in JAMA Open · 1 in Circulation: Heart Failure This remarkable achievement reflects the dedication and collaboration of the @CTCPR_ team. Each study contributes valuable insights that hopefully will help improve patient care and inform clinical practice worldwide. 👏 Huge congratulations to all @CTCPR_ researchers and collaborators for their hard work, perseverance, and commitment to advancing science. @NEJM @thelancet @JAMANetwork @ESC_Journals @JACCJournals @JAMACardio @JAMANetworkOpen @CircHF

How can AI enhance Clinical Trials? In latest @hfcollaboratory Heart of the Matter Podcast @coconnormd & panel share ideas on how to use AI to increase value/quality, design, patient selection, other aspects @mpsotka @dranulala @ankeetbhatt youtube.com/watch?v=r_urcT…

Delighted to have shared the results of ENVAD-HF as late-breaking science at #ESCCongress: 1st prospective RCT of #HeartFailure #GDMT #sacval in #LVADs: -numerically less primary outcome (death, ⬇️ renal fn, hypotn and hyperK) -safe, feasible, well tolerated -improved PROs

In a large individually randomized trial embedded in routine care across a national U.S. health system, a cardiovascular-focused nudge intervention did not increase influenza vaccination rates on a background of low-uptake. Full trial results: eviden.cc/4mo2PZP #ESCCongress

The countdown is on! DANFLU-2 will be presented at #ESCCongress on Saturday! 332,438 adults ≥65 years 👵👴 High-dose vs standard-dose influenza vaccine 💉 Severe outcomes: hospitalizations and deaths 🏥☠️ Design paper: bit.ly/47P65ZE Look out for simpubs! 👀

Very pleased to share our review on AI echocardiography in cardiovascular disease management is now published! I hope this article serves as a resource for continued learning, discussion, and collaboration across the field. 🔗nature.com/articles/s4156…

🧵1/Today, we published a key milestone towards AI based cardiac screening in Nature. doi.org/10.1038/s41586… EchoNext outperformed cardiologists and found thousands of high-risk patients missed in routine care. We also made a version available to the world.