Kalon

1.2K posts

Kalon

Kalon

@Kalonshaka

Years of R&D experience (not an advisor of any kind, just my opinions based on heavy research)

Katılım Haziran 2024
41 Takip Edilen419 Takipçiler
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Kalon
Kalon@Kalonshaka·
$SAVA @elonmusk @RobertKennedyJr There is NO STOPPING SCIENCE no matter how hard CORRUPT WALLSTREET (and we all know who these disgusting criminal Hedgefunds are) try to stop Cassava Sciences by using the recent weight of the government by the bogus SEC actions against $SAVA and the bogus DOJ action against one of the co-inventors, Dr. Wang…. x.com/Kalonshaka/sta… I have posted about this criminal short and distort here.. x.com/Kalonshaka/sta… and here.. x.com/Kalonshaka/sta… and here.. x.com/Kalonshaka/sta… After Cassava Sciences reads out their phase 3 rethink study by EOY, I have very little doubts that it will replicate all the data summarized here…x.com/Kalonshaka/sta… and here…x.com/Kalonshaka/sta… And Cassava has recently said that they are also pursuing additional biological studies with Simufilam as further support (though this is not really needed after phase 3 successful readout imo) AND they are planning and gearing up production of Simufilam to address the gargantuan Alzheimers market! This continued collection of data will further open up the research flood gates into the FLNA pathways and FLNA implications is no many diseases and Cassava has the only drug therapeutic approach to address this pathogenic FLNA pathway. I have posted about this on numerous occasions and different topics and my speculated models and summaries are all based on existing science that no one has articulated before. I summarized these here: 1. The supporting evidence of different (altered) FLNA confirmations here based on FLNA phosphorylation… x.com/Kalonshaka/sta… 2. The extremely potent pico-molar/femto-molar biological activity (confirmed by outside researchers) of simufilam in comparison to most other drug-protein interactions…x.com/Kalonshaka/sta… 3. The connection of FLNA to atherosclerosis.. x.com/Kalonshaka/sta… 4. The connection of FLNA to NASH…x.com/Kalonshaka/sta… 5. The connection of FLNA to integrin/inflammation activation…x.com/Kalonshaka/sta… and …x.com/Kalonshaka/sta… and .. x.com/Kalonshaka/sta… 6. My ALL ROADS LEAD TO ROS post…. x.com/Kalonshaka/sta… 7. My direct connections of APOE gene mutations to ROS-Hypoxia.. x.com/Kalonshaka/sta… and here…x.com/Kalonshaka/sta… 8. Implications to chronic age related diseases.. x.com/Kalonshaka/sta… 9. My hypothesis of FLNA impact to “MILD” Diseaes….. x.com/Kalonshaka/sta… 10. FLNA in Cancer…x.com/Kalonshaka/sta… 11. Links therein and others… Corrupt Wallstreet that started this short and distort against Cassava over 3 years ago were completely oblivious to all this and even Cassava to this day is playing down what they have discovered IMHO! I’ll repeat, the WORLD changes after Phase 3 readout and there’s NOTHING STOPPING SCIENCE!
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Kalon
Kalon@Kalonshaka·
“The problem with your motivated reasoning here is it has been used for every supplement for 100+ years…most of which have been proven to be useless” “No motivated reasoning” nope just following the many orthogonal scientific studies conducted all trending a consistent message. “Proven useless”. Who’s the motivated one? The industry is riddled with anti-competition
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Brian Ingold, DO
Brian Ingold, DO@DrIngold·
You’re right — pharma would never identify a compound in nature with proven benefit, then mimic it in the their lab to develop a concentrated/distilled version they can patent and sell…never The problem with your motivated reasoning here is it has been used for every supplement for 100+ years…most of which have been proven to be useless But the massive supplement industry loves this, they prey on it…they never have to actually test their own product to prove it does what it purports to do — they just get to say “this compound does this in mechanistic/animal trials, we put it in our product” and people eat it up
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Kalon
Kalon@Kalonshaka·
The problem is that no pharma or other sponsor will do studies to “prove” efficacy given the economics and anti-competition of the industry, and this applies to other “anecdotal” cheap therapies, which there are a plethora of. if you look at the basic science expts and animal models with relevant dosing, and data collected, which is not cost onerous to do, one see‘s a vast amount of info that supports the mechanisms behind these interventions. The system establishing proof in healthcare is simply not pragmatic or feasible unfortunately.
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Brian Ingold, DO
Brian Ingold, DO@DrIngold·
What I’m not seeing here is any compelling data to support these assertions. When counseling patients on risks/benefits of an intervention I have to take into account tangible data on potential risks and outcomes data. I don’t get to use N=1 examples or low-quality data to make recommendations because when things go wrong patient’s families are going to (rightly) come ask me how I could have recommended that in good conscience. This isn’t an engineering problem or a closed-loop system, it’s human biology/physiology and we constantly see pieces that should theoretically fit together to affect an outcome actually not adjust the outcome in question (see Niacin and MACE reduction, Lp(a) lowering with meds and event reduction, etc)
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Kalon
Kalon@Kalonshaka·
Because it’s doing more than simply a modest reduction in BP. How do we know? it’s tied to the biology of how those reductions occurs, certainly worth risk given how widely it’s been used. Is it proven? of course not. But put pieces together and you get a compelling benefit/risk
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Brian Ingold, DO
Brian Ingold, DO@DrIngold·
Well I’d argue if it “worked” we would see more consistency across trials. More importantly though, why spend so much $ and take on additional risk of off-target negative effects for 3-4mmHg drop in systolic BP? You can get more robust BP improvement w/less side effect potential for a fraction of the cost, *if one understands human biology* 🤣
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Kalon
Kalon@Kalonshaka·
@DrIngold “Its primary reproducible impact is lowering blood pressure a few points”. This is in fact the reason why it works if one understands the cellular biology!
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Brian Ingold, DO
Brian Ingold, DO@DrIngold·
I’ve posted on Nattokinase several times, but will again address this to see how David’s claims hold up under scrutiny. He is obviously referencing the Chen study here, and there are quite a few things people should immediately know about this study before they try to apply any purported findings more broadly. 1062 participants, all Chinese (completely homogeneous cohort), non-randomized trial -- there was NO placebo/control, NO randomization, and NO blinding. If I'm not mistaken, many of the authors on the paper were employed by the manufacturer of the Nattokinase product being given -- which doesn't immediately discount a trial, but people should know this because they often use this against industry-funded trials. ~93% of participants had BMI <27.4, 2/3 of them averaged >5k steps/day, 75% of them drank little to no alcohol, 10% of them were already on aspirin. It's funny to me that Sinclair prefaces his statement by saying "long-term" but then references this study which was only 12 months in duration. ** Now on to the 95% claim -- as I feel this is the biggest red flag of this whole back & forth. The Chen study absolutely did not show "up to 95% of plaque got removed in 1 year." He would know this if he actually scrutinized the study and accurately represented the baseline characteristics of the participants AND the findings. Only 64% of the trial participants even had carotid plaque at the start of the trial. Meaning that in 36% of participants you couldn't possibly see plaque reversal ("removal" as he states) because it wasn't there to be reversed. In reality, the 95% only applies to the number of participants with improvement in their Total Cholesterol levels. In reality only 66.5% of the trial participants who had measurable plaque saw improvement in Carotid Plaque Scores (CPS)-- and keep in mind this is with higher-dosed NK at 10,800 FU daily. There was 77.7% showing improvement in CIMT -- but again neither CPS or CIMT are evidence of plaque reversal. I'll paste the entire Table 3 from the study below. So either David doesn't actually know what the trial showed, or he does know and just made a mistake here. Either way, what he communicated here regarding this trial is just flat out incorrect. Most importantly, there are zero outcomes measured in this study. No events. That means no measurement of heart attack, stroke, or sudden cardiac death. Now, what else should people know about Nattokinase? Well they should know there are several smaller trials which showed variable/inconsistent impacts on lipids and I'm not aware of any other study in humans showing plaque reduction or regression -- not a single blinded/randomized/placebo-controlled study in humans. There were higher-quality studies done at lower doses over variable time periods (at least one of them over years) that showed no difference in carotid plaque progression. It's primary reproducible impact is lowering blood pressure a few points, and when Sinclair calls it "cheap" it really isn't a low-cost option relative to its peers when it comes to just lowering your BP a few points. Then you get into the safety of such a product. Soybean-based, so allergies are always a significant concern. Beyond that, given the doses required to even see the effect in the Chen trial you're talking about bleeding risk (especially when patients can already be on other medications/supplements which can compound this risk). The safety and quality data just isn't there to confidently say this is a net-value add for humans. At least not as we sit here today in April 2026.
Brian Ingold, DO tweet media
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ScienceGuardians
ScienceGuardians@SciGuardians·
🚨 Compromised / Reckless Journalism — One of the “6 Plagues” Corrupting Academia In his Lindau 2025 lecture, @NobelPrize Laureate @Stanford Professor Thomas C. Südhof explicitly references an article published in Science magazine. The author? Holly Else. Who is Holly Else? We previously exposed her conduct in April–June 2025, when she deployed a series of maneuvers — including the use of a fake email address — in an apparent attempt to prevent the exposure of the fake “science integrity consultant” Elisabeth M. Bik, whose activities we have documented as years of misconduct carried out under the guise of “research integrity,” at that time leveraging the @NatureNV brand. Her efforts were futile — and ultimately played directly into a structured and strategically executed plan by the @SciGuardians Legal & Investigative Team. 📌 Full April–June 2025 exchange between Holly Else and ScienceGuardians™: 👉 scienceguardians.substack.com/p/deception-an… 📌 Full Q&A (unaltered, unedited, preserved exactly as delivered on 2 May 2025): 👉 scienceguardians.substack.com/p/full-q-and-a… Now, returning to her earlier role: On 1 May 2024, under the leadership of @ScienceMagazine Editor-in-Chief Holden Thorp, Holly Else authored the article: “Nobel-winning neuroscientist faces scrutiny for data discrepancies in more than a dozen papers.” This article did not emerge in isolation. In September 2025, we cast much-needed light on what we identified as a preplanned dossier-construction operation — a coordinated smearing and defamation campaign executed by the perpetrators of the PubPeer “PubSmear” Network Mob: 👉 x.com/SciGuardians/s… With the masks now off and the façade collapsing, we urge the academic community to carefully examine this Science magazine article. Link in the first comment. It contains multiple layers of critical signals and information — inadvertently revealed — that expose how such narratives are constructed, amplified, and legitimized, as well as the actors behind them. Compromised journalism is not incidental. It is instrumental. It plays a central role in enabling, scaling, and legitimizing coordinated attacks within the academic ecosystem. And yes — understanding the role of compromised journalists is key to unraveling the architecture of these complex mob networks and their agenda. @SciGuardians 🔱 Empowering Researchers. Restoring Integrity. Eliminating the Plagues Corrupting Academia. 🔱
ScienceGuardians tweet media
ScienceGuardians@SciGuardians

🚨🚨 We previously exposed the PubPeer “PubSmear” Network Mob's signature tactic: 'Working in coordination with fellow network members, they employ the mob’s signature tactic of the ‘PARTIAL TRUTH’ —selectively highlighting fragments of information to construct PUBPEER (aka ‘PUBSMEAR’) dossiers against the scientists they target. Along the way, many additional researchers become collateral damage, serving to conceal the network’s primary targets.' ⚠️ And their central distortion: 'Their central tactic is to falsely equate the number of PubPeer entries with the number of fraudulent papers upon which their harassment, smearing, and defamation campaigns stand — a deliberate distortion designed to mislead the academic community, media, and institutions.' 📌Now Nobel Laureate Thomas C. Südhof confirms the real damage in his Lindau 2025 lecture: 'The cost to especially junior scientists has been enormous... Does it matter if a tree falls in the forest and no one is around to hear it?' Every scientist, researcher, and postgraduate student needs to know about this scandal. What we’ve exposed is only the tip of the iceberg. Watch our 9-min bombshell + @NobelPrize Laureate @Stanford Professor Thomas C. Südhof's Lindau 2025 lecture segment below 👇 Watch it. Spread it. Far more is coming. Stay tuned. @SciGuardians 🔱

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ScienceGuardians
ScienceGuardians@SciGuardians·
🚨 Holden Thorp, Editor-in-Chief of @ScienceMagazine, boasts about it being a 'non-profit journal.' Facts: Its parent org, @aaas, pulled in $129M revenue in 2024 (mostly publishing fees/subs/ads) and holds ~$127M in total assets. Non-profits can amass fortunes (reinvested, not to shareholders), but is this truly non-profit or tax-exempt empire-building? Much more exposed in this 4:27 minute clip. 🧵 Read the attached thread on the Holden Thorp Puzzle, which exposes his enabling of smearing campaigns against high-profile members of the academic community.
ScienceGuardians@SciGuardians

🚨 Holden Thorp Puzzle — Full Q&A Release: The Perpetrator They Tried to Shield Today, we are releasing — in full — the complete set of questions sent by compromised journalist Holly Else and the official ScienceGuardians™ responses exactly as provided to her on 2 May 2025. These Q&As form just one segment of a broader exchange spanning April to June 2025, which we previously published in full (link in the first comment). But this release is different. It places the entire Q&A itself — the heart of her attempted narrative control — into the public record. This document is not merely correspondence. It is evidence — a record of how Else, who had earlier played a central role in defaming @NobelPrize laureate and distinguished @Stanford Professor Thomas C. Südhof through her 1 May 2024 @ScienceMagazine article, under Holden Thorp’s leadership, now returned ready to serve the same mob network once more. Except this time, she acted under the umbrella of another compromised outlet serving the PubPeer “PubSmear” Network Mob’s interests: the news section of @Nature. Her objective was unmistakable: shield Elisabeth Bik from exposure — a mission that failed spectacularly. Because the 🚨 BOMBSHELL SCIENCE INTEGRITY SCANDAL we released on 17 NOV 2025 showed the world exactly what Else was trying to prevent: that Bik and the PubPeer “PubSmear” Network Mob had built an operation dependent on deception, censorship, and narrative manipulation. And that is why they panicked when a 100-follower account began exposing them in early April 2025. They understood that once their tactics, alliances, and concealed misconduct were illuminated, their entire machinery of manufactured authority and anonymous harassment would begin to collapse. And collapse it has. 📌 This email exchange and the full Q&A release are now part of the public record. They reveal: • Else’s reliance on deceptive communication channels • Her attempt to shape the article’s narrative before hearing our side • Her prioritization of PubPeer “PubSmear” Network Mob talking points • Her tactical withdrawal once it became clear that proceeding with the article would further compromise and expose them • Her alignment with the same network later exposed for 100% censorship of critiques against their own flawed work 👉 The link to the full Q&A — unedited, unaltered, and preserved exactly as delivered on 2 May 2025 — will appear in the first comment. This is only one piece of the Holden Thorp Puzzle. More is coming. 🔱 Follow @SciGuardians for the next release.

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ScienceGuardians
ScienceGuardians@SciGuardians·
🚨 Exposed: The Same Playbook — From PubPeer "PubSmear" to Wikipedia 🚨 ⚠️ As revealed by Larry Sanger, Wikipedia’s own co-founder, the platform maintains blacklists determining which outlets can be cited — silencing dissent and protecting establishment narratives. But this bias is no accident. The PubPeer “PubSmear” Network Mob has deeply infiltrated Wikipedia as well. After carrying out their four-stage smear operation — fabrication ➡️ defamation ➡️ legitimization ➡️ formalization — the final act is amplification through biased outlets and their compromised journalists, culminating in manipulated Wikipedia pages targeting their victims. 🧩 The pattern is unmistakable. The same actors. The same agenda. To control the scientific record, erase independent voices, and dominate academia. ⚠️ The time for biased, easily manipulatable platforms such as PubPeer “PubSmear” and Wikipedia is over. 🎥 Watch how the PubPeer “PubSmear” Network Mob operates — and who funds it, why they are rattled, and how the future of post-publication peer review is ScienceGuardians™.👇 🔱 @SciGuardians Accountability. Integrity. Empowerment. @SecKennedy @DrJBhattacharya @IRSnews @ftchina @RWMaloneMD @TuckerCarlson @JasonJournoDC @DailyCaller
Jason Cohen 🇺🇸@JasonJournoDC

🚨NEW: Tucker Carlson *BLOWN AWAY* as Wikipedia Co-Founder Larry Sanger walks him through site’s "BLACKLIST"🤯🤣 "Oh, wow ... this is kind of incredible!" "This is so funny! This is amazing!" @DailyCaller

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ScienceGuardians
ScienceGuardians@SciGuardians·
🚨 The real question is not how many retractions we’ve enforced. It’s how many truths we’ve silenced along the way. 📌 Read the full article by @J_Strachan_Edit and Frank van Geel, published in The Analytical Scientist (@tAnaSci): 🔗 theanalyticalscientist.com/issues/2025/ar…
ScienceGuardians tweet media
ScienceGuardians@SciGuardians

What must be done? Integrity won’t be saved by those who corrupted it. It must be reclaimed by those willing to name what others fear—and build what others failed to imagine. ScienceGuardians™ offers a post-publication peer review platform rooted in ethics, identity verification, and transparency. • One account per user—no multiple identities or sockpuppets. • Each contributor is identity‑verified—not by us, but by virtue of their real institutional affiliation and academic credentials. • Users may remain publicly anonymous, but their identity is always confirmed internally—eliminating pseudonymous drive‑by attacks. • Once verified, users are not subject to moderation—all contributions publish immediately. • Structured, publication‑specific threads keep discussions focused and constructive. • Underpinning all of this is a set of community-anchored ethics guidelines to support authors, editors, reviewers, and institutions in upholding the highest professional standards: 🔗 scienceguardians.com/resources/main We propose: ✅ Verified accountability for all post-publication commentary ✅ Transparent retraction protocols ✅ Institutional oversight of online integrity platforms – to distinguish critique from coordinated abuse. ❌ No more anonymous mass accusations. ✅ Independent reform by scientists—not mobs. “We are not against critique. We are against corruption in the name of critique.” The real question is not how many retractions we’ve enforced. It’s how many truths we’ve silenced along the way. 📌 Read the full article: theanalyticalscientist.com/issues/2025/ar…

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ScienceGuardians
ScienceGuardians@SciGuardians·
OFFICIAL ANNOUNCEMENT ScienceGuardians™ — Restoring Power to the Academic Community and Eliminating the Plagues Corrupting Science ScienceGuardians™ exists to serve and empower the true backbone of science: the more than 20 million authors, reviewers, and editors whose intellectual labor sustains global scientific progress, yet who have been systematically exploited, structurally disempowered, and economically excluded for decades. Science does not belong to publishers. Science does not belong to foundations. Science belongs to those who create it. Authors produce the knowledge. Reviewers safeguard its validity. Editors ensure its integrity. Yet these indispensable contributors receive literally zero economic participation in the multibillion-dollar industry built upon their uncompensated labor. Instead, parasitic intermediaries operating under the label of “academic publishers” have constructed extraordinarily profitable business models by extracting free intellectual labor while retaining nearly all financial value. Major academic publishing corporations—including Elsevier, Springer Nature, Taylor & Francis, Wiley, MDPI, and Frontiers—generate billions of dollars annually in revenue and maintain profit margins rivaling or exceeding those of many of the world’s most successful technology companies. They achieve this not through superior innovation, but through structural deprivation of the very stakeholders upon whom their entire business depends. Authors surrender copyright ownership of their work without compensation. Reviewers provide expert evaluation without compensation. Editors assume enormous responsibility without proportional compensation. Publishers then monetize this uncompensated labor by charging both the public and the academic institutions funded by taxpayers to access the same work created freely by researchers. This structural exploitation created an ecosystem of profound imbalance—an ecosystem within which additional systemic plagues were able to emerge and proliferate. The Structural Reality: Individuals and Foundations Are Not the Center of Science — The Academic Community Is Science and the academic community do not depend on any individual benefactor. Science and the academic community do not depend on any foundation. Science existed before them, and science will exist after them. The academic community itself is the foundation of science, and does not require external control or oversight to correct itself. It is a dynamic system fully capable of self-correction when properly empowered. No individual actor, intermediary, or financial entity is structurally important relative to the collective force of millions of researchers whose work sustains scientific progress. The Plagues Corrupting Academia ScienceGuardians™ has identified six systemic plagues that have metastasized within this disempowered environment: 1. Predatory Publishers and Journals 2. Predatory Practices by So-Called Legitimate Publishers and Journals 3. Paper Mills 4. The PubPeer “PubSmear” Network Mob 5. Predatory Conferences 6. Reckless and Compromised Scientific Journalism These plagues do not exist in isolation. They operate symbiotically, exploiting the structural vulnerability of researchers while shielding themselves behind institutional legitimacy and financial backing. Among these, the PubPeer “PubSmear” Network Mob represents one of the most deliberately constructed and systemically harmful forces. This network consists of approximately thirty individuals, including non-academics and low-profile actors who have exploited the disempowered academic ecosystem for personal and institutional gain. Operating under the public guise of “research integrity,” this network has engaged in coordinated reputational attacks, targeted harassment, narrative manipulation, and systematic exploitation of structural asymmetries within academia. Major enabling infrastructure for this ecosystem—including the PubPeer Foundation and Retraction Watch—has received sustained financial support through Arnold Ventures LLC (formerly the Laura and John Arnold Foundation). ScienceGuardians™ acknowledges that philanthropic contributors may not always have full operational visibility into downstream conduct enabled by their financial resources. Accordingly, we extend John Arnold and Laura Arnold the professional courtesy of assuming that their financial resources may have been deployed without their full awareness of downstream operational consequences. However, structural responsibility cannot be separated from financial enablement. Financial enablement carries an obligation of oversight. Financial enablement carries an obligation of accountability. Financial enablement carries an obligation of correction when harm has been enabled. Opportunity for Transparency, Audit, and Public Accountability ScienceGuardians™, on behalf of the academic community, formally invites Arnold Ventures LLC to conduct a comprehensive internal audit of all funding relationships connected to entities operating within the post-publication and research integrity ecosystem. This audit should determine: • How financial resources were deployed • Whether those resources enabled systemic harassment or reputational manipulation • Whether corrective actions are necessary ScienceGuardians™ further invites public disclosure of audit findings and appropriate corrective measures, including public clarification and acknowledgment of harm where applicable. A reasonable timeframe for such review and disclosure is fourteen (14) days starting from the date of this official announcement. This notice is issued in good faith and as a professional courtesy to enable transparency and correction. For clarity and factual precision, the Connection Web referenced in our recent analysis originates from evidence held within U.S. Department of Justice-associated Epstein Library archives (File No.: EFTA01104262). As with any such material, appearance within a network map does not, by itself, imply wrongdoing, and proper interpretation requires full contextual understanding. What remains relevant is the broader, well-documented pattern of efforts by certain billionaire actors to influence and control scientific and academic ecosystems, which appropriately invites scrutiny of associated institutional relationships and enabling structures, including those connected to Arnold Ventures LLC. ScienceGuardians™: Institutional Authority Rooted in the Academic Community ScienceGuardians™ is operated by a dedicated team of highly skilled data and IT professionals who have undergone extensive training in academic publishing, ethics, and integrity. While not publishing authors themselves, these experts have been thoroughly educated in the full lifecycle of academic publication, including peer review, authorship standards, conflict of interest management, editorial workflows, and scientific misconduct prevention. ScienceGuardians™ has developed the first Fully Verified Post-Publication Peer Review Platform, where academics can interact freely—without moderation or censorship and without fear of harassment or intimidation—available at scienceguardians.com. In parallel, ScienceGuardians™ provides comprehensive ethical guidelines, training resources, and educational infrastructure designed to empower the academic community and eradicate misconduct through structural reform and awareness, available at scienceguardians.com/docs/main/. ScienceGuardians™ is entirely self-sustained. It receives no corporate sponsorship and accepts no cash donations. Its operations are supported through the voluntary contributions of senior scientists, legal advisors, and ethics and integrity experts who have chosen to waive their professional fees in support of restoring fairness, accountability, and integrity to the academic ecosystem. Final Professional Courtesy Notice This announcement is issued as a final professional courtesy to all actors whose financial resources, institutional infrastructure, or operational support may have enabled systemic harm within the academic ecosystem. We are fully aware of the identities of the PubPeer “PubSmear” Network Mob, their enablers, and their promoters across multiple jurisdictions worldwide. These include actors embedded within compromised editorial structures, affiliated media channels, research integrity offices within academic publishing organizations, and complicit or compromised academic actors operating within institutional environments. We have documented these operational structures, identified enabling mechanisms, and securely archived extensive evidence concerning coordinated activities, systemic exploitation, and reputational manipulation. Transparency and corrective action remain the responsible path forward. ScienceGuardians™ remains committed to restoring integrity, protecting researchers, and eliminating the systemic plagues corrupting academia. The academic community is no longer structurally defenseless. The era of unchecked exploitation is ending. ScienceGuardians™ The First Fully Verified Post-Publication Review Platform 🔱 Empowering Researchers. Restoring Integrity. Eliminating the Plagues Corrupting Academia. 🔱
ScienceGuardians tweet media
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Kalon@Kalonshaka·
@SciGuardians Clear, precise…awesome post with important information that most of public is completely unaware of! 👏
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sabine hazan md
sabine hazan md@SabinehazanMD·
@BillAckman Papers in the medical literature are being retracted at an alarming rate. The Arnold Foundation has funded and supported platforms like PubPeer, which have played a central role in driving those retractions. An innocent person deserves the right to face their accuser directly. Instead, the response has been systematic censorship of anyone whose work threatens powerful financial interests—interests explicitly tied to figures like @BillAckman and his portfolio. I ask you plainly: Why did the Arnold Foundation sponsor PubPeer to retract a scientific hypothesis on ivermectin (IVM)? And why is an organization connected to the now-discredited, fraudulent uBiome venture now leading attacks against @weldeiry? If you genuinely stand for innocence and transparency, then speak. Because right now, the widespread perception—mine and that of many others—is that the Arnolds are far from innocent in these matters. When science itself is interfered with, it harms every one of us. Even within your own circles, people are quietly questioning the Arnolds’ role. @SciGuardians may have pushed their investigations too far—or they may be hitting the exact target. Either way, the moment papers are retracted, courageous physicians are smeared, and honest scientists are attacked, a line was crossed and conflict began. We can keep waging this war of mutual destruction, or we can choose to sit down at the table and talk. The decision is yours, @johnarnold. I see patterns that go far beyond the surface. The way certain attacks involving Epstein are being weaponized appears designed to reflect on an entire religion. Nothing here is coincidental. As human beings under God, we are called to seek the path of righteousness. True righteousness does not involve destroying the reputations of dedicated scientists and physicians who have devoted their lives to a discipline that is, by its very nature, provisional and evolving. In science, very little is ever permanently “true” or “false”—it is always subject to new evidence. What matters is that it advances. Smearing those who follow where the evidence leads is not defense of science; it is its betrayal. Let us choose dialogue over destruction. The choice is ours.
Bill Ackman@BillAckman

Th Epstein Files have reached the McCarthy-era stage where innocent people are being slandered. We need to distinguish between evildoers and those who ‘appear’ in the Epstein files, but have done nothing wrong. I am hearing of totally innocent people being forced to resign from boards etc. because their name appears somewhere in the documents. Let’s return to a world where people are presumed innocent until they are proven guilty.

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Kalon@Kalonshaka·
Kalon@Kalonshaka

$SAVA @RobertKennedyJr @SecKennedy @joerogan @MikeBenzCyber Long awaited, the additional data analysis from the Cassava Science simufilam Phase 3 (Rethink and Refocus trials) in mild-moderate Alzheimer‘s has been published in Journal of Prevention of Alzheimer’s Diseas: #sec0023" target="_blank" rel="nofollow noopener">sciencedirect.com/science/articl… As anticipated there were major design flaws, impacting both of these large studies (~1800 patients in total), including: 1). problems with the use of ptau181 for screening, likely allowing portions of MCI or very early AD patients which is not the intended patient population for these trials, given the unprecedented slow placebo group decline for a presumably classified mild-moderate patient population in both studies, and 2). Questionable use of ADAS-COG12 instead of the more discriminating ADAS-COG13 in light of the likely highly variable “mild” population in both studies. For example, in the MABs (Lecanemab and donanemab) approved studies in MCI-Mild Alzheimers patients the more discriminatory ADAS-COG13 was used. 3). early stoppage of Refocus study (an 18 month trial) that made the final 18 month time-point reliant on data modeling due to nearly 50% missing data and the result of data modeling that shows ADAS-COG12 placebo flattening from 12-18 months, see graph below…which is absurd given historical rates of significant dramatic decline from 12-18 months in Alzheimer’s patients classified as mild-moderate. Despite these major trial flaws, incredibly, in the pre-specified mild group analysis for the 18 month Refocus study (714 patients-a very large group), there was a dramatically LARGE statistically significant (p <0.05) ADAS-COG12 effect from simufilam treatment in the preceding time-points (1 month, 6 months, 9 months, 12 months, and 15 months, see graph below), prior to 18 month time-point (end of study and the time-point with the significant missing data). This result is for an astonishing 714 patients In the combined 3-arms (100 mg, 50 mg, and placebo groups). In addition the change from baseline on ADAS-Cog12 in the highest half (≥ 67 pg/mL) of plasma p-tau181 from the ITT population of RETHINK (367 patients) showed large differences at Weeks 28, 40 and 52 (p=0.009, p=0.048 and p=0.036), graph below. This is for an astonishing 367 patients! Given that both trials failed their primary and secondary endpoints, the authors of this publication are forced to formally call these additional data analyses “nominal“ results (the Refocus pre-specified, 714 mild patients and Rethink post-hoc analyses for highest half (≥ 67 pg/mL) of plasma p-tau181, 367 patients). but I beg to differ, and also in light of the flawed elements of the study described above. I compel @MartyMakary @US_FDA to take note of these ”nominal results” as well as the entire scientific community @DrJBhattacharya @RWMaloneMD @SabinehazanMD @DrJeffCummings and think pragmatically what this science and simufilam could mean to the Alzheimer’s community. @alzassociation @CTADconference Also recall that the pubsmear mob and their short and distort sponsors tried to discredit Cassava Sciences, by attacking simufilam and the FLNA science, Dr. Hoau-Yan Wang, amongst many other targets as also discussed by @SciGuardians and recently attacks against @weldeiry. The pubsmear and short and distort anti-competitive forces led to a bogus FDA citizens petition against Cassava Sciences, an SEC $40 million fine of Cassava Sciences, fake media (NYT, WSJ, Science Magazine, others) blitz against Cassava, class-action lawsuits as a result typical of such short and distort campaigns perpetrated by Wallstreet, CUNY investigation of Dr. Wang, and Biden’s DOJ attempted prosecution, which fell apart after CUNY provided exculpatory evidence and DOJ unprecedentedly dropping all prosecution at the 11th hour this past October, knowing their case was bogus! This all showcases complete injustice, criminal short and distort, and anti-competitive forces against real and valid science that was perpetrated against Cassava and Dr. Wang, and this is all documented in time.

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John Arnold
John Arnold@johnarnold·
There's a social network map floating around X that someone created that lists roughly 100 people including 13 people as a close friend, including Laura and me. Epstein is also listed as a close friend of the creator. An anonymous X account is implying that means Epstein and I were close friends. To set the record perfectly straight: neither Laura nor I ever met or spoke with Epstein. Ever. The X account that makes this claim has repeatedly slandered me over the past year. I'm sure he will continue to do so. He won't stop our work.
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Kalon
Kalon@Kalonshaka·
@BillAckman Want proof of the corrupt PubPeer (Pubsmear) campaigns?, read about Dr. Hoau-Yan Wang and Cassava Sciences $SAVA short and distort campaigns… x.com/Kalonshaka/sta…
Kalon@Kalonshaka

$SAVA @RobertKennedyJr @SecKennedy @joerogan @MikeBenzCyber Long awaited, the additional data analysis from the Cassava Science simufilam Phase 3 (Rethink and Refocus trials) in mild-moderate Alzheimer‘s has been published in Journal of Prevention of Alzheimer’s Diseas: #sec0023" target="_blank" rel="nofollow noopener">sciencedirect.com/science/articl… As anticipated there were major design flaws, impacting both of these large studies (~1800 patients in total), including: 1). problems with the use of ptau181 for screening, likely allowing portions of MCI or very early AD patients which is not the intended patient population for these trials, given the unprecedented slow placebo group decline for a presumably classified mild-moderate patient population in both studies, and 2). Questionable use of ADAS-COG12 instead of the more discriminating ADAS-COG13 in light of the likely highly variable “mild” population in both studies. For example, in the MABs (Lecanemab and donanemab) approved studies in MCI-Mild Alzheimers patients the more discriminatory ADAS-COG13 was used. 3). early stoppage of Refocus study (an 18 month trial) that made the final 18 month time-point reliant on data modeling due to nearly 50% missing data and the result of data modeling that shows ADAS-COG12 placebo flattening from 12-18 months, see graph below…which is absurd given historical rates of significant dramatic decline from 12-18 months in Alzheimer’s patients classified as mild-moderate. Despite these major trial flaws, incredibly, in the pre-specified mild group analysis for the 18 month Refocus study (714 patients-a very large group), there was a dramatically LARGE statistically significant (p <0.05) ADAS-COG12 effect from simufilam treatment in the preceding time-points (1 month, 6 months, 9 months, 12 months, and 15 months, see graph below), prior to 18 month time-point (end of study and the time-point with the significant missing data). This result is for an astonishing 714 patients In the combined 3-arms (100 mg, 50 mg, and placebo groups). In addition the change from baseline on ADAS-Cog12 in the highest half (≥ 67 pg/mL) of plasma p-tau181 from the ITT population of RETHINK (367 patients) showed large differences at Weeks 28, 40 and 52 (p=0.009, p=0.048 and p=0.036), graph below. This is for an astonishing 367 patients! Given that both trials failed their primary and secondary endpoints, the authors of this publication are forced to formally call these additional data analyses “nominal“ results (the Refocus pre-specified, 714 mild patients and Rethink post-hoc analyses for highest half (≥ 67 pg/mL) of plasma p-tau181, 367 patients). but I beg to differ, and also in light of the flawed elements of the study described above. I compel @MartyMakary @US_FDA to take note of these ”nominal results” as well as the entire scientific community @DrJBhattacharya @RWMaloneMD @SabinehazanMD @DrJeffCummings and think pragmatically what this science and simufilam could mean to the Alzheimer’s community. @alzassociation @CTADconference Also recall that the pubsmear mob and their short and distort sponsors tried to discredit Cassava Sciences, by attacking simufilam and the FLNA science, Dr. Hoau-Yan Wang, amongst many other targets as also discussed by @SciGuardians and recently attacks against @weldeiry. The pubsmear and short and distort anti-competitive forces led to a bogus FDA citizens petition against Cassava Sciences, an SEC $40 million fine of Cassava Sciences, fake media (NYT, WSJ, Science Magazine, others) blitz against Cassava, class-action lawsuits as a result typical of such short and distort campaigns perpetrated by Wallstreet, CUNY investigation of Dr. Wang, and Biden’s DOJ attempted prosecution, which fell apart after CUNY provided exculpatory evidence and DOJ unprecedentedly dropping all prosecution at the 11th hour this past October, knowing their case was bogus! This all showcases complete injustice, criminal short and distort, and anti-competitive forces against real and valid science that was perpetrated against Cassava and Dr. Wang, and this is all documented in time.

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Bill Ackman
Bill Ackman@BillAckman·
Th Epstein Files have reached the McCarthy-era stage where innocent people are being slandered. We need to distinguish between evildoers and those who ‘appear’ in the Epstein files, but have done nothing wrong. I am hearing of totally innocent people being forced to resign from boards etc. because their name appears somewhere in the documents. Let’s return to a world where people are presumed innocent until they are proven guilty.
John Arnold@johnarnold

There's a social network map floating around X that someone created that lists roughly 100 people including 13 people as a close friend, including Laura and me. Epstein is also listed as a close friend of the creator. An anonymous X account is implying that means Epstein and I were close friends. To set the record perfectly straight: neither Laura nor I ever met or spoke with Epstein. Ever. The X account that makes this claim has repeatedly slandered me over the past year. I'm sure he will continue to do so. He won't stop our work.

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ScienceGuardians
ScienceGuardians@SciGuardians·
The Epstein Files are indeed the least of the matter. What is at stake here is more than a decade of orchestrated harassment, smearing, and defamation campaigns targeting researchers and scientists who dare to challenge the status quo, all under the guise of “Research Integrity,” carried out by a mob network now widely known within the academic community as the PubPeer “PubSmear” Network Mob, whose elements were enabled by the Laura and John Arnold Foundation (now Arnold Ventures). Operating at the highest levels, they coordinated efforts to cancel, isolate, and silence dissenting voices while protecting their own operatives within this mob network. These actions have been documented and securely archived. The evidence speaks loudly and clearly. x.com/SciGuardians/s…
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ScienceGuardians
ScienceGuardians@SciGuardians·
🚨 Epstein's leaked "Connections Web" (File EFTA01104262) explicitly labels Laura Arnold and John Arnold as his Close Friends—exposing the chilling overlap in these predator billionaires' networks that power their science influence operations. The Arnolds-funded "Research Integrity Machine", aka the PubPeer "PubSmear" Network Mob, mirrors the Gates-Epstein ResearchGate playbook... but deploys a far more insidious mechanism: forced retractions and targeted smears for narrative control in science and academia. See the damning web (note the "Close Friends" section). 🔱 Follow @SciGuardians to stay informed and empowered.
ScienceGuardians tweet media
ScienceGuardians@SciGuardians

🚨 Evidence drops — follow the money and the playbook these predator billionaires use to hijack science: 👉 See the full thread exposing the Bill Gates-Jeffrey Epstein-ResearchGate scandal: How Gates & Epstein secretly bought CONTROL over what scientists discover, share, and believe—through ResearchGate's platform dominance, insider hype, and leverage on publishers. Leaked emails, contracts, and patterns laid bare. x.com/SciGuardians/s… 👉 See the accumulated evidence exposing the John & Laura Arnold "Research Integrity Machine" scandal: Millions poured over a decade into PubPeer (aka "PubSmear"), Retraction Watch/Center for Scientific Integrity, Center for Open Science, Sense About Science & more—to force targeted retractions, orchestrate smears/defamation via the PubPeer "PubSmear" Network Mob, instill fear, hide agendas, and DICTATE what science can say. x.com/SciGuardians/s… @SecKennedy @DrJBhattacharya @elonmusk @BillAckman @HHS_ORI @NIH @C0PE

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Kalon
Kalon@Kalonshaka·
$SAVA @SciGuardians @weldeiry @SabinehazanMD @elonmusk this is exactly similar tactics of what was done to Cassava Sciences and Dr. Hoau-Yan Wang, easily hacking Wiki since 2021, drafting their narratives for their anti-competitive aims (even after countless corrections, never ending hacking from unlimited resources by Hedgefunds), PubPeer (pubsmear) mob campaign, short and distort, paid media hit pieces across many platforms, bogus SEC and DOJ investigations under Biden, heavily manipulating options marker to cover up their illegal naked shorting. Complete corruption of so many facets in the US. It’s Unbelievable but all documented in time!
War Monitor@WarMonitors

⚡️#BREAKING Insane document found in Epstein files ID: EFTA02416819

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Kalon
Kalon@Kalonshaka·
Dr. El-Deiry, it‘s no coincidence who the PubPeer (PubSmear) targets are and are fully sponsored by corrupt and criminal largest investment firms. With short and distort tactics, prime example Cassava Sciences $SAVA, and many others. The system is unbelievably corrupt and disgusting has been going on for many years. It‘s now finally coming to light some of the atrocities of this system which is simply based on greed and anti-competition and with the prime goal of controlling the scientific narrative as @SciGuardians has excellently described.
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Wafik S. El-Deiry, MD, PhD, FACP
About damage caused by PubPeer and their collaborators. After 20 months of investigations with no findings of any fraud or misconduct at multiple universities there have now been new “concerns” that have resulted in new planned investigations. The ongoing criminal activities I have been subjected to and their consequences are not ok. I am suggesting that @HHS and @NIH provide very clear guidance to universities and publishers in light of the weaponization of PubPeer. Absent that intervention, the consequences of their criminal targeting activities will continue to damage the careers and reputations of countless collaborating scientists. The activities of PubPeer have been exposed by @SciGuardians. There is selective targeting and cancellation of individuals that is very well documented. There is no statute of limitations. There is no attention to the significance of any concerns. There is the phenomenon of piling it on and overwhelming systems with concerns. There’s a double standard with those aligned with PubPeer when there are concerns about their work. I won’t mention names but this is documented by @SciGuardians I urge NIH/HHS to intervene immediately to stop the persecution of innocent individuals that occurs under the effort to identify fraud. The process turns into a witch-hunt with a tone of guilty until proven innocent. The investigations involve time consuming demands and deadlines. There needs to be intervention and justice. There should be no investigations by a system in need of urgent reform. The system has been manipulated by a criminal mob including by individuals based outside the US and those who investigate have no choice but to investigate. This should cease until the harms are understood and the motives of the attackers are further exposed. If hundreds of scientists are persecuted to catch one fraudulent actor, one has to look at the process that leads to the persecution and determine whether it is moral or ethical. It is part of a false narrative that there is widespread corruption and fraud in academic science. The current patterns of investigation are unethical and immoral. The consequences of damaged careers as a direct result of never ending investigations launched due to the concerns of an anonymous mob are very serious with destruction of reputations, employment viability, success with grant funding or paper publication. The damages are severe and those responsible must be held accountable. Some have chosen to settle for large sums of many millions of dollars going to members of PubPeer’s inner circle and this is further incentivizing criminal activity. I have brought awareness of the world’s literature on cancers that occurred after Covid mRNA vaccination along with other documented harms and mechanisms. This should not be the basis of persecution within the US. I have provided national service for 8 months working with other experts. The journal that published the article @Oncotarget was subjected to a cyberattack and censorship activity. @HHSGov should ensure that those who serve their country are not targeted, censored, or eliminated because someone isn’t happy about the narrative or emerging truth. The US government (@FBIDirectorKash, @DHSgov, @CIA, @SECGov) should investigate the attackers and protect those who are being attacked. Thank you for your attention. @SecKennedy @DrJBhattacharya @VPrasadMDMPH @RetsefL @KUPERWASSERLAB @RWMaloneMD @MaryanneDemasi @danaparish @efenigson @Kevin_McKernan @JesslovesMJK @Jikkyleaks @DJSpeicher @xazalbert @P_McCulloughMD @NicHulscher @SabinehazanMD @SenRonJohnson @SenBillCassidy @RandPaul @AaronSiriSG
Wafik S. El-Deiry, MD, PhD, FACP@weldeiry

Orchestrated malicious attacks by PubPeer mob were noticed by colleagues like @Kevin_McKernan & also exposed by @SciGuardians but have not stopped. Attacks continue with public online harassment around the clock unchecked by government or anyone else with damaging consequences.

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Robert W Malone, MD
Robert W Malone, MD@RWMaloneMD·
Lots of posts going around that glyphosate is perfectly safe - years of safety data. So, here are 109 peer-reviewed papers on glyphosate - please read and then come back and argue how harmless it is. BTW - who do you think is paying these "experts" to write post after post on social media about how "safe and effective" glyphosate is? I have my own ideas, but what do you think? 1. Acquavella J. Epidemiologic studies of glyphosate and non-Hodgkin's lymphoma: A review with consideration of exposure frequency, systemic dose, and study quality. Glob Epidemiol. 2023;5:100101. 2. Alcala-Perez MA, Hernandez-Fuentes GA, Garza-Veloz I, Diaz-Llerenas U, Martinez-Fierro ML, Guzman-Esquivel J, et al. Glyphosate as an Emerging Environmental Pollutant and Its Effects on Breast Cancer Cell Proliferation: A Systematic Literature Review of Preclinical Evidence. Toxics. 2025;14(1). 3. Almiron A, Lorenz V, Varayoud J, Durando M, Milesi MM. Perinatal Exposure to Glyphosate or a Commercial Formulation Alters Uterine Mechanistic Pathways Associated with Implantation Failure in Rats. Toxics. 2024;12(8). 4. Argou-Cardozo I, Zeidan-Chulia F. Clostridium Bacteria and Autism Spectrum Conditions: A Systematic Review and Hypothetical Contribution of Environmental Glyphosate Levels. Med Sci (Basel). 2018;6(2). 5. Ashley-Martin J, Marro L, Owen J, Borghese MM, Arbuckle T, Bouchard MF, et al. Gestational urinary concentrations of glyphosate and aminomethylphosphonic acid in relation to preterm birth: the MIREC study. J Expo Sci Environ Epidemiol. 2024. 6. Bao Y, He X, Zhai Y, Shen W, Jing M, Liu Y, et al. Effects of glyphosate-based herbicide on gut microbes and hepatopancreatic metabolism in Pomacea canaliculata. Ecotoxicol Environ Saf. 2024;280:116549. 7. Barnett JA, Bandy ML, Gibson DL. Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis? Front Nutr. 2022;9:827384. 8. Bellot M, Carrillo MP, Bedrossiantz J, Zheng J, Mandal R, Wishart DS, et al. From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish. Ecotoxicol Environ Saf. 2024;270:115888. 9. Ben Maamar M, Beck D, Nilsson EE, Kubsad D, Skinner MK. Epigenome-wide association study for glyphosate induced transgenerational sperm DNA methylation and histone retention epigenetic biomarkers for disease. Epigenetics. 2021;16(10):1150–67. 10. Bloem BR, Boonstra TA, Elbaz A, Vermeulen RCH. Glyphosate and neurotoxicity - a call for scientific renewal. Nat Rev Neurol. 2024;20(3):131–2. 11. Buchenauer L, Haange SB, Bauer M, Rolle-Kampczyk UE, Wagner M, Stucke J, et al. Maternal exposure of mice to glyphosate induces depression- and anxiety-like behavior in the offspring via alterations of the gut-brain axis. Sci Total Environ. 2023;905:167034. 12. Buchenauer L, Junge KM, Haange SB, Simon JC, von Bergen M, Hoh AL, et al. Glyphosate differentially affects the allergic immune response across generations in mice. Sci Total Environ. 2022;850:157973. 13. Bukowska B, Wozniak E, Sicinska P, Mokra K, Michalowicz J. Glyphosate disturbs various epigenetic processes in vitro and in vivo - A mini review. Sci Total Environ. 2022;851(Pt 2):158259. 14. Canosa IS, Zanitti M, Medesani DA, Lopez Greco LS, Rodriguez EM. Effects of glyphosate on sperm quality of the estuarine crab Neohelice granulata, under the "One Health" perspective. Sci Total Environ. 2024;948:174879. 15. Centner TJ, Russell L, Mays M. Viewing evidence of harm accompanying uses of glyphosate-based herbicides under US legal requirements. Sci Total Environ. 2019;648:609–17. 16. Chaiklieng S, Uengchuen K, Gissawong N, Srijaranai S, Autrup H. Biological Monitoring of Glyphosate Exposure among Knapsack Sprayers in Khon Kaen, Thailand. Toxics. 2024;12(5). 17. Chandran D, Jayaraman S, Sankaran K, Veeraraghavan VP, R G. Antioxidant Vitamins Attenuate Glyphosate-Induced Development of Type-2 Diabetes Through the Activation of Glycogen Synthase Kinase-3 beta and Forkhead Box Protein O-1 in the Liver of Adult Male Rats. Cureus. 2023;15(12):e51088. 18. Chang VC, Andreotti G, Ospina M, Parks CG, Liu D, Shearer JJ, et al. Glyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study. J Natl Cancer Inst. 2023;115(4):394–404. 19. Chang VC, Ospina M, Xie S, Andreotti G, Parks CG, Liu D, et al. Urinary biomonitoring of glyphosate exposure among male farmers and nonfarmers in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study. Environ Int. 2024;187:108644. 20. Chianese T, Trinchese G, Leandri R, De Falco M, Mollica MP, Scudiero R, et al. Glyphosate Exposure Induces Cytotoxicity, Mitochondrial Dysfunction and Activation of ERalpha and ERbeta Estrogen Receptors in Human Prostate PNT1A Cells. Int J Mol Sci. 2024;25(13). 21. Chu PL, Wang CS, Wang C, Lin CY. Association of urinary glyphosate levels with iron homeostasis among a representative sample of US adults: NHANES 2013-2018. Ecotoxicol Environ Saf. 2024;284:116962. 22. Cirstea AE, Docea AO, Cercelaru L, Drocas AI, Mesnage R, Marginean C, et al. Changes in Rat Mammary Tissue Architecture Following Pregnancy/Lactation Exposure to Glyphosate Alone or with 2,4-D and Dicamba. Curr Health Sci J. 2024;50(1):94–105. 23. Connolly A, Jones K, Basinas I, Galea KS, Kenny L, McGowan P, et al. Exploring the half-life of glyphosate in human urine samples. Int J Hyg Environ Health. 2019;222(2):205–10. 24. De Almeida LKS, Pletschke BI, Frost CL. Moderate levels of glyphosate and its formulations vary in their cytotoxicity and genotoxicity in a whole blood model and in human cell lines with different estrogen receptor status. 3 Biotech. 2018;8(10):438. 25. de Lima ESC, Pelosi C. Effects of glyphosate on earthworms: From fears to facts. Integr Environ Assess Manag. 2024;20(5):1330–6. 26. de Morais Valentim JMB, Coradi C, Viana NP, Fagundes TR, Micheletti PL, Gaboardi SC, et al. Glyphosate as a Food Contaminant: Main Sources, Detection Levels, and Implications for Human and Public Health. Foods. 2024;13(11). 27. de Oliveira MAL, Rojas VCT, de Sa JC, de Novais CO, Silva MS, de Almeida Paula HA, et al. Perinatal exposure to glyphosate-based herbicides induced neurodevelopmental behaviors impairments and increased oxidative stress in the prefrontal cortex and hippocampus in offspring. Int J Dev Neurosci. 2022;82(6):528–38. 28. de Souza JS, Laureano-Melo R, Herai RH, da Conceicao RR, Oliveira KC, da Silva I, et al. Maternal glyphosate-based herbicide exposure alters antioxidant-related genes in the brain and serum metabolites of male rat offspring. Neurotoxicology. 2019;74:121–31. 29. Dinep-Schneider O, Appiah E, Dapper A, Patterson S, Vermulst M, Gout JF. Effects of the glyphosate-based herbicide roundup on C. elegans and S. cerevisiae mortality, reproduction, and transcription fidelity. Environ Pollut. 2024;356:124203. 30. Dong Y, Li Y, Ma L, Shu S, Ren J, Yu X, et al. Associations between Glyphosate Exposure and Glycemic Disorders: A Focus on the Modifying Effect of Sex Hormones. Toxics. 2024;12(8). 31. Dorlach T, Gunasekara S. The politics of glyphosate regulation: lessons from Sri Lanka's short-lived ban. Global Health. 2023;19(1):84. 32. Dou JR, Yang Y, Zhang H, Zhang F, Zhao Y, Miao RF. [Analysis of 5 patients with acute glyphosate poisoning clinical characteristics and metabolic concentration]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2024;42(8):608–12. 33. Dovolou E, Nanas I, Giannoulis T, Fytsilli A, Ntemka A, Anifandis G, et al. The effects of a glyphosate-based herbicide on the bovine gametes during an in vitro embryo production model. Environ Pollut. 2024;350:123967. 34. El Hamzaoui A, Lamtai M, El Brouzi MY, Azirar S, Rezqaoui A, Zghari O, et al. Melatonin attenuates affective disorders and cognitive deficits induced by perinatal exposure to a glyphosate-based herbicide via antioxidant pathway in adult male and female rats. Int J Dev Neurosci. 2024. 35. Fang YW, Wang C, Lin CY. Association between urinary glyphosate levels and hand grip strength in a representative sample of US adults: NHANES 2013-2014. Front Public Health. 2024;12:1352570. 36. Faria M, Bedrossiantz J, Ramirez JRR, Mayol M, Garcia GH, Bellot M, et al. Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety. Environ Int. 2021;146:106253. 37. Fathi MA, Shen D, Luo L, Li Y, Elnesr SS, Li C. The exposure in ovo to glyphosate on the integrity of intestinal epithelial tight junctions of chicks. J Environ Sci Health B. 2024;59(4):183–91. 38. Gao Y, Shu S, Zhang D, Wang P, Yu X, Wang Y, et al. Association of Urinary Glyphosate with All-Cause Mortality and Cardiovascular Mortality among Adults in NHANES 2013-2018: Role of Alkaline Phosphatase. Toxics. 2024;12(8). 39. Good P. Evidence the U.S. autism epidemic initiated by acetaminophen (Tylenol) is aggravated by oral antibiotic amoxicillin/clavulanate (Augmentin) and now exponentially by herbicide glyphosate (Roundup). Clin Nutr ESPEN. 2018;23:171–83. 40. Grundler F, Seralini GE, Mesnage R, Peynet V, Wilhelmi de Toledo F. Excretion of Heavy Metals and Glyphosate in Urine and Hair Before and After Long-Term Fasting in Humans. Front Nutr. 2021;8:708069. 41. Han K, Gao L, Xu H, Li J, Han L, Shen J, et al. Analysis of the association between urinary glyphosate exposure and fatty liver index: a study for US adults. BMC Public Health. 2024;24(1):703. 42. Hardell L, Carlberg M, Nordstrom M, Eriksson M. Exposure to phenoxyacetic acids and glyphosate as risk factors for non-Hodgkin lymphoma- pooled analysis of three Swedish case-control studies including the sub-type hairy cell leukemia. Leuk Lymphoma. 2023;64(5):997–1004. 43. Hariti M, Kamel A, Ghozlani A, Djennane N, Djenouhat K, Aksas K, et al. Disruption of spermatogenesis in testicular adult Wistar rats after short-term exposure to high dose of glyphosate based-herbicide: Histopathological and biochemical changes. Reprod Biol. 2024;24(2):100865. 44. Hashimoto K, Hammock BD. Reply to Reeves and Dunn: Risk for autism in offspring after maternal glyphosate exposure. Proc Natl Acad Sci U S A. 2021;118(2). 45. He X, Yang Y, Zhou S, Wei Q, Zhou H, Tao J, et al. Alterations in microbiota-metabolism-circRNA crosstalk in autism spectrum disorder-like behaviours caused by maternal exposure to glyphosate-based herbicides in mice. Ecotoxicol Environ Saf. 2024;285:117060. 46. Huang Y, Huang Q, Zhou K, Luo X, Long W, Yin Z, et al. Effects of glyphosate on neurotoxicity, oxidative stress and immune suppression in red swamp crayfish, Procambarus Clarkii. Aquat Toxicol. 2024;275:107050. 47. Jauregui-Zunzunegui S, Rodriguez-Artalejo F, Tellez-Plaza M, Garcia-Esquinas E. Glyphosate exposure, muscular health and functional limitations in middle-aged and older adults. Environ Res. 2024;251(Pt 1):118547. 48. Jayaraman S, Krishnamoorthy K, Prasad M, Veeraraghavan VP, Krishnamoorthy R, Alshuniaber MA, et al. Glyphosate potentiates insulin resistance in skeletal muscle through the modulation of IRS-1/PI3K/Akt mediated mechanisms: An in vivo and in silico analysis. Int J Biol Macromol. 2023;242(Pt 2):124917. 49. Kale OE, Vongdip M, Ogundare TF, Osilesi O. The use of combined high-fructose diet and glyphosate to model rats type 2 diabetes symptomatology. Toxicol Mech Methods. 2021;31(2):126–37. 50. Kubsad D, Nilsson EE, King SE, Sadler-Riggleman I, Beck D, Skinner MK. Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology. Sci Rep. 2019;9(1):6372. 51. Li W, Lei D, Huang G, Tang N, Lu P, Jiang L, et al. Association of glyphosate exposure with multiple adverse outcomes and potential mediators. Chemosphere. 2023;345:140477. 52. Li ZM, Jeong H, Kannan K. Widespread occurrence of glyphosate and aminomethylphosphonic acid in indoor dust from urban homes across the United States and its contribution to human exposure. Environ Int. 2024;192:109005. 53. Liang Q, Liu BY, Zhang TL, Zhang HJ, Ren YL, Wang HP, et al. Chronic dietary exposure to glyphosate-induced connexin 43 autophagic degradation contributes to blood-testis barrier disruption in roosters. Sci Total Environ. 2024;951:175606. 54. Liang Z, Sun X, Guo R, Wang H, Tian Y, Wang Y, et al. Association between glyphosate exposure and osteoarthritis in US adults: Especially in people who are obese and inactive in leisure time physical activity. Sci Total Environ. 2024;927:172008. 55. Lopez-Valcarcel ME, Del Arco A, Parra G. Zooplankton vulnerability to glyphosate exacerbated by global change. Sci Total Environ. 2024;913:169806. 56. Lu J, Zhang C, Wang W, Xu W, Chen W, Tao L, et al. Glyphosate Causes Vascular Toxicity through Cellular Senescence and Lipid Accumulation. Chem Res Toxicol. 2023;36(7):1151–61. 57. Lucia RM, Liao X, Huang WL, Forman D, Kim A, Ziogas A, et al. Urinary glyphosate and AMPA levels in a cross-sectional study of postmenopausal women: Associations with organic eating behavior and dietary intake. Int J Hyg Environ Health. 2023;252:114211. 58. Ma C, Gu G, Chen S, Shi X, Li Z, Li-Byarlay H, et al. Impact of chronic exposure to field level glyphosate on the food consumption, survival, gene expression, gut microbiota, and metabolomic profiles of honeybees. Environ Res. 2024;250:118509. 59. Madani NA, Carpenter DO. Effects of glyphosate and glyphosate-based herbicides like Roundup on the mammalian nervous system: A review. Environ Res. 2022;214(Pt 4):113933. 60. Mandrioli D, Panzacchi S. [Global Glyphosate Study: new evidence on carcinogenic effects of glyphosate and glyphosate-based pesticides]. Epidemiol Prev. 2025;49(4):252–3. 61. Meftaul IM, Venkateswarlu K, Dharmarajan R, Annamalai P, Asaduzzaman M, Parven A, et al. Controversies over human health and ecological impacts of glyphosate: Is it to be banned in modern agriculture? Environ Pollut. 2020;263(Pt A):114372. 62. Mesnage R, Antoniou MN. Facts and Fallacies in the Debate on Glyphosate Toxicity. Front Public Health. 2017;5:316. 63. Mink PJ, Mandel JS, Lundin JI, Sceurman BK. Epidemiologic studies of glyphosate and non-cancer health outcomes: a review. Regul Toxicol Pharmacol. 2011;61(2):172–84. 64. Mitton GA, Corona M, Alburaki M, Iglesias AE, Ramos F, Fuentes G, et al. Synergistic effects between microplastics and glyphosate on honey bee larvae. Environ Toxicol Pharmacol. 2024;111:104550. 65. Moller SR, Campos MA, Rilling JI, Bakkour R, Hollenback AJ, Jorquera MA, et al. Persistence and pathway of glyphosate degradation in the coastal wetland soil of central Delaware. J Hazard Mater. 2024;477:135238. 66. Moraes JS, Ballesteros ML, Hued AC, Bonifacio AF, Azambuja TG, Vaz BDS, et al. Glyphosate and its formulated product Roundup Transorb R(R) affect locomotor activity and reproductive and developmental parameters in Jenynsia lineata fish: An intergenerational study. Chemosphere. 2024;362:142541. 67. Morozov AA, Yurchenko VV. Changes in the liver proteome of zebrafish (Danio rerio) exposed to glyphosate and aminomethylphosphonic acid in the presence of a humic substance. Pestic Biochem Physiol. 2024;204:106036. 68. Motta EVS, de Jong TK, Gage A, Edwards JA, Moran NA. Glyphosate effects on growth and biofilm formation in bee gut symbionts and diverse associated bacteria. Appl Environ Microbiol. 2024;90(8):e0051524. 69. Munoz JP, Araya-Osorio R, Mera-Adasme R, Calaf GM. Glyphosate mimics 17beta-estradiol effects promoting estrogen receptor alpha activity in breast cancer cells. Chemosphere. 2023;313:137201. 70. Nunes RFN, Marciano LPA, Oliveira GS, Cardoso NS, Paula FBA, Sarpa M, et al. Glyphosate contamination of drinking water and the occurrence of oxidative stress: Exposure assessment to rural Brazilian populations. Environ Toxicol Pharmacol. 2024;108:104476. 71. Nunes Torres JA, de Lima DCA, Moraes V, de Oliveira Cardoso MV, de Araujo Ribeiro LA, Silva FS, et al. Maternal exposure to glyphosate-based herbicide causes vascular dysfunction in offspring female rats. Toxicol Appl Pharmacol. 2024;484:116873. 72. Otaru S, Jones LE, Carpenter DO. Associations between urine glyphosate levels and metabolic health risks: insights from a large cross-sectional population-based study. Environ Health. 2024;23(1):58. 73. Panza SB, Vargas R, Balbo SL, Bonfleur ML, Granzotto DCT, Sant'Ana DMG, et al. Perinatal exposure to low doses of glyphosate-based herbicide combined with a high-fat diet in adulthood causes changes in the jejunums of mice. Life Sci. 2021;275:119350. 74. Parimi DS, Jyothirmai MV, Ravva MK, Jaiswal AK, Suresh AK. Bioengineering of Cu(2)O structured macro-biotemplate for the ultra-efficient and selective hand-retrieval of glyphosate from agro-farms. Sci Total Environ. 2024;921:171051. 75. Pasquier L, Lecureuil C, Meunier J. Limited effects of a glyphosate-based herbicide on the behaviour and immunity of males from six populations of the European earwig. Environ Sci Pollut Res Int. 2024;31(31):44205–17. 76. Pawlak R, Wooten A, Selim M, Kew K. Reassuring Quantitative Analysis of Glyphosate and Aminomethylphosphonic Acid Levels in Breast Milk Using Liquid Chromatography Mass Spectrometry. Breastfeed Med. 2024;19(9):742–5. 77. Porru S, Ferrian M, Mastrangelo G, Capovilla D, Corsini E, Fustinoni S, et al. Short occupational exposure to glyphosate and its biomonitoring via urinary levels of glyphosate and metabolite AMPA (Amino-MethylPhosphonic acid), in Italian vineyard workers. Heliyon. 2024;10(16):e36407. 78. Prasad M, Gatasheh MK, Alshuniaber MA, Krishnamoorthy R, Rajagopal P, Krishnamoorthy K, et al. Impact of Glyphosate on the Development of Insulin Resistance in Experimental Diabetic Rats: Role of NFkappaB Signalling Pathways. Antioxidants (Basel). 2022;11(12). 79. Pu Y, Ma L, Shan J, Wan X, Hammock BD, Hashimoto K. Autism-like Behaviors in Male Juvenile Offspring after Maternal Glyphosate Exposure. Clin Psychopharmacol Neurosci. 2021;19(3):554–8. 80. Pu Y, Yang J, Chang L, Qu Y, Wang S, Zhang K, et al. Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2020;117(21):11753–9. 81. Qi X, Huang Q, Chen X, Qiu L, Wang S, Ouyang K, et al. Associations between urinary glyphosate and diabetes mellitus in the US general adult: a cross-sectional study from NHANES 2013-2016. Environ Sci Pollut Res Int. 2023;30(59):124195–203. 82. Qu M, Cheng X, Xu Q, Hu Y, Liu X, Mei Y. How do glyphosate and AMPA alter the microbial community structure and phosphorus cycle in rice-crayfish systems? Environ Res. 2024;260:119679. 83. Radivojevic I, Stojilkovic N, Antonijevic-Miljakovic E, Dordevic AB, Baralic K, Curcic M, et al. In silico attempt to reveal the link between cancer development and combined exposure to the maize herbicides: Glyphosate, nicosulfuron, S-metolachlor and terbuthylazine. Sci Total Environ. 2024;949:175187. 84. Reeves W, Dunn SE. Additional observations regarding glyphosate-based herbicides and developmental toxicity. Proc Natl Acad Sci U S A. 2021;118(2). 85. Rodrigues NR, de Souza APF. Occurrence of glyphosate and AMPA residues in soy-based infant formula sold in Brazil. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018;35(4):723–30. 86. Romualdo GR, de Souza JLH, Valente LC, Barbisan LF. Assessment of the impact of glyphosate and 2,4-D herbicides on the kidney injury and transcriptome changes in obese mice fed a Western diet. Toxicol Lett. 2023;385:1–11. 87. Romualdo GR, Valente LC, de Souza JLH, Rodrigues J, Barbisan LF. Modifying effects of 2,4-D and Glyphosate exposures on gut-liver-adipose tissue axis of diet-induced non-alcoholic fatty liver disease in mice. Ecotoxicol Environ Saf. 2023;268:115688. 88. Romualdo GR, Valente LC, Dos Santos ACS, Grandini NA, Camacho CRC, Vinken M, et al. Effects of glyphosate exposure on western diet-induced non-alcoholic fatty liver disease in mice. Environ Toxicol Pharmacol. 2023;104:104286. 89. Rosolen APF, Ribeiro RA, Teleken JL, de Oliveira Chaves J, Padilha SC, Goes ME, et al. Pubertal glyphosate-based herbicide exposure aggravates high-fat diet-induced obesity in female mice. Environ Sci Pollut Res Int. 2024;31(10):15872–84. 90. Rueda-Ruzafa L, Cruz F, Roman P, Cardona D. Gut microbiota and neurological effects of glyphosate. Neurotoxicology. 2019;75:1–8. 91. Salgado Kiefer YCS, Ferreira MB, da Luz JZ, Filipak Neto F, Oliveira Ribeiro CA. Glyphosate and aminomethylphosphonic acid metabolite (AMPA) modulate the phenotype of murine melanoma B16-F1 cells. Environ Toxicol Pharmacol. 2024;107:104429. 92. Samsel A, Seneff S. Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies. Surg Neurol Int. 2015;6:45. 93. Santovito A, Nota A, Pastorino P, Gendusa C, Mirone E, Prearo M, et al. In vitro genomic damage caused by glyphosate and its metabolite AMPA. Chemosphere. 2024;363:142888. 94. Schluter HM, Bariami H, Park HL. Potential Role of Glyphosate, Glyphosate-Based Herbicides, and AMPA in Breast Cancer Development: A Review of Human and Human Cell-Based Studies. Int J Environ Res Public Health. 2024;21(8). 95. Schwientek M, Rugner H, Haderlein SB, Schulz W, Wimmer B, Engelbart L, et al. Glyphosate contamination in European rivers not from herbicide application? Water Res. 2024;263:122140. 96. Seneff S, Kyriakopoulos AM, Nigh G. Is autism a PIN1 deficiency syndrome? A proposed etiological role for glyphosate. J Neurochem. 2024. 97. Shaw W. Elevated Urinary Glyphosate and Clostridia Metabolites With Altered Dopamine Metabolism in Triplets With Autistic Spectrum Disorder or Suspected Seizure Disorder: A Case Study. Integr Med (Encinitas). 2017;16(1):50–7. 98. Shaw W. Hypothesis: 2 Major Environmental and Pharmaceutical Factors-Acetaminophen Exposure and Gastrointestinal Overgrowth of Clostridia Bacteria Induced By Ingestion of Glyphosate-Contaminated Foods-Dysregulate the Developmental Protein Sonic Hedgehog and Are Major Causes of Autism. Integr Med (Encinitas). 2024;23(3):12–23. 99. Sheppard L, Shaffer RM. Re: Glyphosate Use and Cancer Incidence in the Agricultural Health Study. J Natl Cancer Inst. 2019;111(2):214–5. 100. Spulber S, Reis L, Alexe P, Ceccatelli S. Decreased activity in zebrafish larvae exposed to glyphosate-based herbicides during development-potential mediation by glucocorticoid receptor. Front Toxicol. 2024;6:1397477. 101. Tang P, Wang Y, Liao Q, Zhou Y, Huang H, Liang J, et al. Relationship of urinary glyphosate concentrations with glycosylated hemoglobin and diabetes in US adults: a cross-sectional study. BMC Public Health. 2024;24(1):1644. 102. Thiel KL, da Silva J, Wolfarth M, Vanini J, Henriques JAP, de Oliveira IM, et al. Assessment of cytotoxic and genotoxic effects of glyphosate-based herbicide on glioblastoma cell lines: Role of p53 in cellular response and network analysis. Toxicology. 2024;508:153902. 103. Valente LC, de Matos Manoel B, Reis ACC, Stein J, Jorge BC, Barbisan LF, et al. A mixture of glyphosate and 2,4-D herbicides enhances the deleterious reproductive outcomes induced by Western diet in obese male mice. Environ Toxicol. 2024;39(1):31–43. 104. Vazquez DE, Verellen F, Farina WM. Early exposure to glyphosate during larval development induces late behavioural effects on adult honey bees. Environ Pollut. 2024;360:124674. 105. Villeneuve PJ, Harris SA. Re: exposure to phenoxyacetic acids and glyphosate as risk factors for non-Hodgkin lymphoma. Leuk Lymphoma. 2024;65(1):138–40. 106. Ward MH, Madrigal JM, Jones RR, Friesen MC, Falk RT, Koebel D, et al. Glyphosate in house dust and risk of childhood acute lymphoblastic leukemia in California. Environ Int. 2023;172:107777. 107. Weisenburger DD. An Update of Evidence that the Herbicide Glyphosate (Roundup) is a Cause of Non-Hodgkin Lymphoma. Clin Lymphoma Myeloma Leuk. 2025. 108. Yildirim EA, Laptev GY, Tiurina DG, Gorfunkel EP, Ilina LA, Filippova VA, et al. Investigating adverse effects of chronic dietary exposure to herbicide glyphosate on zootechnical characteristics and clinical, biochemical and immunological blood parameters in broiler chickens. Vet Res Commun. 2024;48(1):153–64. 109. Zhu Y, Hu Y, Zhou Q, Ruan L, Zhou S, Xia B, et al. Association of glyphosate exposure with kidney function impairment in the adolescents and young adults' population in the U.S. National Health and Nutrition Examination Survey, 2013 to 2016. Paediatr Child Health. 2025;30(7):560–7.
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