Cris

Super interested in early biotech startups in NYC. Would love to chat with others about it / DM me! Scientists , business folks or otherwise encouraged!

We didn't win against Iran but at least it didn't cost us 300 billion USD. 🤷‍♂️

Published in the Journal of the American Chemical Society, a Mount Sinai study has identified a previously hidden druggable site in a cancer-related protein that could open the door toward a new generation of more precise cancer drugs. The study focused on PKMYT1, a kinase that helps control how cells grow and divide. Using a combination of AI-based protein prediction tools and laboratory experiments, researchers discovered an entirely new "hidden" pocket in PKMYT1 where a molecule could bind — a site that current state-of-the-art AI systems missed. The findings suggest that proteins such as PKMYT1 are far more flexible than previously appreciated, constantly shifting between different shapes rather than existing in a single fixed form. This could eventually help scientists develop more selective drugs that avoid some of the toxicity and specificity challenges associated with traditional kinase inhibitors — and may also help improve future AI systems by teaching them to better recognize hidden and dynamic protein states. To read more about the research, visit: mshs.co/4fzuO8f #ArtificialIntelligence #Cancer #Research @TischCancer

Look, I get it, a lot of you aren't enthusiastic this week because it's the Men's World Cup, not the actual World Cup -- but give it a chance. Boys play soccer, too!

Extraordinary advances #ASCO2026 in deadliest cancers show that cancer cures are increasingly within reach. Biggest limitation now is not science, but funding. We need a stronger NIH to remain at the forefront of discovery and keep fighting for US lives. #doubleNIHBUDGET

This one is hard to see. The NIH Early Independence Award, one of the most competitive grants in the country for young scientists, will not go forward in FY2026. NIH says this is due to “administrative changes to funding opportunity processing and delays in approvals.”

Wooooahh!!!

@highbrow_nobrow Was your flagpole damaged from beating a police officer on January 6? You may be entitled to compensation.

The Trump administration has authorized the continued use of cancer-causing pesticide atrazine. Atrazine is banned in more than 60 countries.

Expanding the CRISPR genome editing toolkit: A flip from RNA-guided DNA targeting to DNA-guided RNA targeting @NatureBiotech nature.com/articles/s4158… nature.com/articles/s4158… nature.com/articles/s4158…

@BravoCorderoLab @cris_megino @SinaiBrain @TischCancer @CoRESinai Felicidades !

Congratulations to our postdoc @cris_megino for winning the #ArtOfTheBrain image contest at the @SinaiBrain 18th Annual Neuroscience Retreat with this beautiful image. 🧠✨ 🏆 1st Place – Best Image Contest ❤️ 2nd Place – Most “Liked” Social Media Image @TischCancer @CoRESinai

Breaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. scim.ag/4u133d3

I vote it bird picture of the year !

Nothing says Make America Healthy Again like appointing a tobacco executive to be a leader at the CDC

U.S. President Donald Trump has fired all 24 members of the National Science Board, the body that oversees the National Science Foundation. Many science advocates see it as the latest step by his administration to erode—some would say destroy—the independence of the 76-year-old research agency. scim.ag/4eGM0YS

Excited to share our latest review on cancer #dormancy with my colleagues at @EinsteinMed @WenjunGuoLab @soledadsosa80 Gregoire lauvau and Julio Aguirre-Ghiso in @NatureRevCancer. @IcahnMountSinai @TischCancer

Vinay Prasad forced FDA scientists to withdraw a paper from Vaccine, the journal I am co-EIC of, because it showed that COVID vaccines work for everyone 6 months+. This is Gold Standard Science at Marty Makary’s FDA. Setting the Gold Standard in corruption & graft

I am very happy to share that our paper is now published in @Nature 😊 Cell-type-targeted mitochondrial transplantation rescues cell degeneration. nature.com/articles/s4158… @IOB_ch (1/6)

🤔How do you design a promoter for stable titration of expression? 💡Try programmable promoter editing with DIAL! 📰Now published at @NatureBiotech 🧵 [1/n] 🔗 below

BREAKING: In response to huge cuts in Trump's budget request, NSF is closing its social sciences directorate. Staff will be transferred elsewhere in NSF, and "grants that align with Administration priorities" will be kept. W/ @dangaristo for @Nature nature.com/articles/d4158…

We are deeply disappointed by President Trump's Fiscal Year 2027 budget request to Congress today. The president's proposal would be a giant step backward for American health and innovation. "From cutting biomedical research at NIH to slashing other STEM funding at NSF, this budget would make our 250th year one of restricting, rather than realizing, our full potential." - Research!America President and CEO Mary Woolley Read our full statement for more details. researchamerica.org/press-releases…