Dr Andrew Wettenhall

@drkeithsiau Exorcism?

What treatment is being delivered here?

@drpablocorral @alavallecobo @nicolasrennamd @lschreier1 @matias_fer @magabrielama83 x axis labelling looks off on the skewed distributions

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@hjluks Beautifully put, well done! No doubt other non medical professionals will also relate but it does feel like medical practice exposes us to the full rawness of unfiltered humanity. An addictive simultaneous privilege and burden.

@lowcarbGP @PHCukorg @rcgp @drericwestman @DoctorChrisVT @drchatterjeeuk @ExpressGilo @ClareWilsonMed @lowcarb_aus @keto_live @timspector good to see another Australian collaboration - not quite a Gila monster

Why have I got a giant lizard on my shoulder ?? She is helping with my Public Health Collaboration lecture May 31 in central London And this year my talk is (mostly) not about low carb!! phcuk.org/phc-conference… @PHCukorg @rcgp @drericwestman @DoctorChrisVT Her name is Saphira !!

@MohammedAlo @Drlipid @garytaubes Before treating meat as causal of diabetes or anything else I would want to know if the association stands when controlled for known causal variables like total energy content, sucrose/hfcs, refined carbohydrates as well as looking at lean vs fatty meat.

I agree. I read Taubes book and find it useful. Even tried to follow that diet previously. But the claimed health benefits are exaggerated. With regards to the claims regarding keto, is mostly about red meat intake. I posted the studies. A great study was fine by Harvard that was a prospective study with 5.7 million person years of follow up that showed that those in the highest quintile of red meat intake had 62% higher incidence of diabetes compared to the lowest quintile. It was also validated by food logs, not just food recall questionnaires. I agree that maybe it was a bit over the top and hysterical response, but it seems that people won't read the studies or data unless they are confronted with outcomes that sound horrific. Diabetes is the leading cause of blindness, amputations, kidney failure worldwide and we need to combat this. We have some of these issues in the United States as well, especially in underserved populations.

I have to strongly disagree with my friend’s declaration. I think there is no data to support those seemingly hysterical claims. Also @garytaubes book “Why we get fat” should not be described as nonsense. I found it to be incredibly insightful and impactful. I know Gary and although not always agreeing with all if his current beliefs, he does his investigative homework and deserves respect.

@tednaiman @where_im_at This is one of the most useful metabolism learning points Ive got from you over recent years - explains why its not just carbs. Thanks

@where_im_at Nice work! My only pushback is that when you did have high glucose, the apple would raise your glucose immediately but having a fatty sausage for dinner would raise your glucose the next morning — the area under the curve is nearly identical, only the timescale is different.

Highest: 180 lbs, A1c 5.9% Current: 160 lbs, A1c 4.6% No, I was not born at the finish line. 😅

@tednaiman 👊🏻

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@DrAliceHod @DrEenfeldt Hava promotes mid range satiety scores to ensure adequate calories . No possibility of rabbit starvation unless misused

@DrEenfeldt No. That just promotes “rabbit starvation” with all protein and no energy.

Controversial, but it shouldn't be: Type 2 diabetes is not a disease of carbohydrate toxicity. Type 2 diabetes is a disease of *energy* toxicity. About 99% of the toxic energy is stored as fat in the body. Drastically limiting carbohydrates works because it results in eating fewer calories. This is likely due to higher protein & almost complete elimination of addictive ultra-processed foods. However, our data demonstrate that there's something even more effective. Even zero carb is a "local maximum;" it's effective but not the most effective approach. Most likely, a high-SPC approach will be far more flexible and sustainable. Our data (to be shared soon) indicates it's also significantly more effective at reducing caloric intake. We aim to collect data on results for weight and then blood glucose too. Most likely, those will point in the same direction as data on caloric intake. Bottom line: Type 2 diabetes is not just about carbohydrate toxicity. I used to believe so myself, but it's not the whole story. Type 2 diabetes is about overall energy toxicity. In the body, this toxic energy is overwhelmingly stored as fat, not carbohydrates.

@ViralRNA @ViralRNA is the issue with the current vaccine just the unit cost?

Open for applications: fully funded PhD on the Development of a novel and affordable vaccine for worldwide elimination of hepatitis A virus. Project focuses on molecular virology and viral immunology to generate HAV Virus-Like Particles in tobacco plants mrc-lid.lshtm.ac.uk/2025-26-projec…

@jrkdenison @docmilanfar although with both our eyes pointing forward the other eye compensates unlike in the octopus

@docmilanfar Indeed. Another evolutionary bodge job is that the nerve fibres from the rod and cone cells in our retinas pass through from the front of our retina into the optic nerve, causing a blind spot, rather than passing behind the retina, like they do in (for example) octopuses.

My meager education in biology and evolution gave me the mistaken impression that evolution optimized everything. But it didn't. One example is the recurrent laryngeal nerve (RLN). It goes from behind your ear, loops down below your aorta, and then back up to the voice-box 1/2

@drkeithsiau Apparent Neutrophilia that is really demargination, Dysglycaemia, atrophy of nearly everything except adipose tissue, Na/fluid retention

What am I missing? 😅

@IsgittJohn @hufcm @Drlipid “Normal” LDL-C/ApoB is still easily enough to promote atherosclerosis

@hufcm @Drlipid Except that he won’t explain why half of all heart attack victims have normal LDL levels.

Well other than my official portrait above in the little circle above here is my coolest photo update (cataracts fixed - no need for glasses) - Sent to me by my friend Ohio Cardiologist Chris Huff @hufcm Great shirt and hoping my heart is as strong as the one in the graphic. The Reverse has a logo - "Premier Cardiovascular Health and Performance" @nationallipid @society_eas @lipiddoc @FamilyHeartFdn @DrEveHenry1 @DrRalphEsposito @PeterAttiaMD

@tednaiman @NutritionMadeS3 Awesome Ted! but labour intensive for the nearly everyone on earth that use mmol/L for lipid panel and nmol/L for Apo B. No chance of either showing both or choosing units before you enter data ? I believe ApoB conversion is 1mg/dL=18.18 nmol/L (based on 550,000 g/mol for ApoB)

@NutritionMadeS3 For those with a plain boring ordinary lipid panel but no ApoB [i.e. maybe not literally everyone, but statistically speaking everyone you know and everyone on earth] I am inserting a shameless plug here for: 😁 ApoBCalc.com

Updated summary of ApoB recommendations by the NLA treatment threshold = 90mg/dL for borderline/intermediate risk, 70 for high, 60 for very high lipid.org/sites/default/…

@Drlipid Thankyou!

Lipidaholics - The finale is here - for part 9 of "Understanding the complexities of hepatic sterol homeostasis." Add these graphics to your archives as you will never find them elsewhere. Here I explain the ABCB4 efflux transporter that sends phospholipids to the bile which act as an emulsifier - phosphatidyl choline joins with bile acids (from ABCB11) and cholesterol from ABCG5/ABCG8 to form mixed micelles. Hope all have mastered much described in the multi-part series. I hope it helps the deniers realize that truly understanding cholesterol takes a little study 😁🧐🤐@nationallipid @society_eas @escardio @atherosociety @FamilyHeartFdn

@NutritionMadeS3 @Sixtyminutes23 If only COVID how long would you expect the dip to last. Surely insulin resistance related pathology is at least part of the plateauing.

@Sixtyminutes23 covid

"everyone's sicker so all science must be wrong" this is an internet trope obesity & diabetes are up heart disease death was cut in half over the last 50y. life expectancy shot up cholesterol and BP are down some things are worse, some are better beware the story-telling

Excellent Dementia piece in mainstream media this morning. abc.net.au/news/2024-09-1…

@BenBikmanPhD IBS & IBD are different things Ben. IBS frequently attributed to plant food triggering. For IBD its less clear but it would be pretty unlikely food has nothing to do with it of course.

The impact and relevance of this case study shouldn't be overlooked. IBS (inflammatory bowel disease) is often a lifelong struggle, filled with various failed attempts to improve the disease. Most people would never think that a primary trigger for their IBS is the plants they eat. As indicated in the report, the more the patients removed plants and focused on animal-sourced nutrition, the better they got. @nicknorwitz @AdrianSotoMota @SBakerMD @reverohealth frontiersin.org/journals/nutri…

@drkeithsiau An e on the end of large intestine

Length of the GI tract 📏 - Are there any edits you would suggest?

@BenBikmanPhD Doesnt hyperinsulinaemia directly induce leptin resistance in the hypothalamus independent of circulating leptin levels?

Leptin is an important metabolic hormone. We need it to work well. When it doesn’t, we fall into leptin resistance. One cause of leptin resistance is too much leptin! But what is responsible for the excess levels of leptin? Let’s discuss. #leptin #leptinresistance #metabolism #insulin #insulinresistance #lowcarb #lowcarbbrasil #ketoweightloss #keto

@tednaiman Well its made in the liver so if you choke the cells with triglyceride it shouldn't be a total surprise if hepatic synthetic function takes a hit

🤔