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Want to add spatial coordinates to your single cell data?
Check out Slide-tags, out today in @Nature!
nature.com/articles/s4158…
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Jackson Weir
230 posts
Jackson Weir
@jacksonweir4
PhD candidate in Fei Chen's lab @insitubiology @BBS_Harvard @broadinstitute | spatial omics, tumor evolution, tissue dynamics | prev: @UNB
Cambridge, MA Katılım Şubat 2016
2.5K Takip Edilen780 Takipçiler
Great to see this out, congrats @Vignesh_Shan! I had a lot of fun thinking about Hodgkin lymphoma during my rotation with you at the start of grad school.
Vignesh Shanmugam@Vignesh_Shan
1/ It has long been known that microenvironmental signals can drive tumor growth, particularly in tumors that are rich in non-malignant cells — yet the specific signals have remained a mystery. Hodgkin lymphoma is the exemplar, with rare tumor cells (<1%!) reliant on such signals. We set out to define these signals 🧵 Paper: rdcu.be/e2KuZ
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Jackson Weir retweetledi
I am excited to share our latest preprint, in which we demonstrate that systemic hypoxia suppresses solid tumor growth.
This has been a tremendous collaborative effort in the labs of @IshaHJain and @Genophoria at @GladstoneInst, @ArcInstitute, and @UCSF.
biorxiv.org/content/10.648…
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Jackson Weir retweetledi
Excited to share our study @CellCellPress introducing a novel class of macrophage-targeted immunocytokines (MiTEs) that engage myeloid, T and NK cells to boost anti-tumor immunity in solid tumors. Led by @MVLocquenghien, @PascaleZwicky & @CuriousKX (1/16)
cell.com/cell/abstract/…
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Excited to share our study covering an extensive examination of genetic dependencies and cell surface targets datasets for PDAC is out! Long road to my first first-author publication! Grateful for the great team and amazing support through this process. Congrats to all involved!
Cell Reports@CellReports
Integrative genomic identification of therapeutic targets for pancreatic cancer dlvr.it/TMdKH2
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Still lots to learn about clonal T cell proliferation in the post-CAR-T setting.
Very cool experience to work closely with the clinical team @DanaFarber on this one. Big thanks to @Dr_KatieM, Caron Jacobson, Cathy Wu, @insitubiology and the rest of the team!
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Check out our new paper on a potential secondary malignancy following CAR-T therapy! Histopathology was consistent with a T cell lymphoma but the sample was CAR negative and spontaneously resolved without treatment.
nature.com/articles/s4146…
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Thrilled to share that I’m joining @MGHPathology, @harvardmed & @broadinstitute as an Assistant Professor! 🚀 The Xia Lab is entering a new chapter at both MGH and Broad - building biologically informed ML/AI models to decode genome regulation & engineer cell fates. Stay tuned for some exciting works to come soon! #GenomicsAI We are also hiring at all levels!
Our mission:
🤖 Predictive AI models + high-throughput in silico screens
🧬 Unravel the foundational programs of gene & genome regulation
🧫 Scalable cell fate engineering & de novo cell design for regeneration & healthy aging
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@MattG_Jones @MITBiology @kochinstitute @MIT_IMES Huge congrats!! Looking forward to seeing you around in the fall!
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It's official - I am thrilled to share that I am joining @MITBiology, the @kochinstitute, and @MIT_IMES as an Assistant Professor this fall! We will be a hybrid lab combining new technologies and computation to study ecDNA and tumor evolution.
thejoneslaboratory.com
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Our work is now online in the new Neuron issue @NeuroCellPress, alongside other labs from the BRAIN Armamentarium Consortium! We have developed enhancer-AAVs to target diverse cortical interneuron subtypes: cell.com/neuron/fulltex…
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Incredibly inspiring
David R. Liu@davidrliu
In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe, rapidly progressing genetic disease... all in an astounding 7 months. Best of all, the infant patient shows apparent benefit. Congratulations to @kiranmusunuru, Rebecca Ahrens-Nicklas, and other team members for this heroic and inspiring effort, which has implications for the hundreds of millions of patients that suffer from thousands of genetic diseases. drive.google.com/file/d/1Jfku5j…
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Our work on 3D genome organization in human cancer is out! In collaboration with @ZYanding @HowardYChang @WJGreenleaf and TCGA we used HiChIP to profile enhancer connectivity and rewiring in primary tumors.
nature.com/articles/s4158…
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Very cool
Systems_Immunology_WIS@Sys_Immunology
Congrats our @Sys_Immunology lab @YMerbl for a new masterpiece study @Nature highlighting the existence of multiple endogenous proteosome-cleaved peptides featuring an anti-microbial activity! A fantastic read and a fascinating finding, way to go guys! nature.com/articles/s4158…
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Congrats @TyMillerLab, @CouturierMDPhD and team! Super awesome to see this out.
Ty Miller Lab@TyMillerLab
Proud to share our latest work in @nature, co-led by @chadi_elfarran, @CouturierMDPhD & @BradEBernstein! We developed a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies🧵 nature.com/articles/s4158…
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Check out this great paper led by @rumya_r and @mircoscopy!
Rumya@rumya_r
1/ Thrilled to share an advancement in gene therapy from my PhD in @NatureComms! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to @zhangf & @mircoscopy! bit.ly/redicas9
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Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵
This was an incredible team effort w/ @jenngarrison @Tammyinlab @davidsebfischer AlisonKochersberger @RuthRaichur @sophiamszady
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@hattaca @jenngarrison @Tammyinlab @davidsebfischer @RuthRaichur @sophiamszady Congrats Hattie and the rest of the team!
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Great time presenting our work with @Dr_KatieM, Cathy Wu, and Caron Jacobson at ASH today on secondary T cell malignancies following CAR-T therapy!
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