Jack Hansen
1.1K posts
@patrickc There’s still some value in tools that give reproducible outputs. I work in this space and I would worry about variability run to run just because there are so many things it could focus on. Tools like Promethease, SelfDecode, Gene2Rx are good because the same algorithms are used
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I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools.
With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments.
Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know.
I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars.
(One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.)
There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!
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@GeneSmi96946389 @SethSHowes There’s some services that do this properly since it is more than most people can handle it’s probably better to use those. Genomisaur is one pretty good one for PRS
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Neither alpha genome nor evo 2 are particularly good at assessing your polygenic risk scores for anything. You’re using some of the weakest models out there because you’re the prestige of a model as a proxy for how much insight it can shed on your results.
If you actually wanted to do this properly you’d pull sum stats from the PGS catalog and use the predictor with the highest r^2 (ideally one that has been validated within-family)
You’re still going to have a bit of a nightmare on your hands though because you’ll need to do sex and genetic ancestry norming to calculate actual lifetime risk.
Also, not all predictors in the PGS catalog report their r^2 performance, so for those that don’t, you’ll need to validate it on some hold-out set. Not to mention, if you’re not European you’ll need to deflate the performance metrics to account for loss of predictive power that comes from bias in the training datasets.
People think you can just vibe code this shit and they’re wrong. Just solving the dataset access issue takes like a year. You can’t validate these predictors or test their performance without access to validation data.
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I’ve wanted to do this for a decade.
But I never did - I refuse to give any company my DNA.
It is me.
So this week I sequenced my genome entirely at home. Literally on my kitchen table.
I never exposed my DNA sequence to the internet. Not at any point.
I used a MinION to do the sequencing (it’s smaller + weighs less than an iPhone).
I used open-source DNA models for the analysis (Evo2 and AlphaGenome) running locally on a DGX Spark and Mac Studio.
I traced mechanisms behind my family’s multigenerational autoimmune conditions that no clinician has been able to understand.
When I set out to do this I didn’t know if it would actually work. It does.
Your genome is the most private data you will ever have. You probably shouldn’t let it leave your house.
Patrick Collison@patrickc
I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools. With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments. Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know. I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars. (One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.) There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!
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@texasrunnerDFW Everyone that bought between 2021 and now is going to get burned soon, everyone. So many people will be underwater be 30-50%
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@MakeTrying27534 @WallStreetApes Guess you didn’t watch the video
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The younger generation is so used to having everything handed to them without any effort put forth on their part. They get the latest technology, buy expensive drinks on a daily (or more) basis, order door dash, spend frivolously. Never once have they considered the true cost or saving.
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American says both his grandparents were school teachers. One of them stopped working to raised their kids, so their income was only about $20,000 per year
On $20,000 in a year, he was able to buy a house, support a family of four, buy 2 cars, send my father to private school. He was even able to retire 10 years early
He says this kind of life is now impossible and that’s why young people feel “hopeless”
“But in 2026, our government, our society is geared solely towards maintaining the wealth and comfort of the boomer generation. Every year without fail, proposals that help young people, proposals that help poor people, first time home buyers, yada, yada, yada fail in Congress. — But every year, hundreds of billions of dollars in Social Security increases sail through the chambers of Congress without a second thought. There is really no support system for the younger generation at this point.”
“Most people are trying to come to grips with the fact that they are never going to be able to retire at all, let alone retire 10 years early. It's just not the same world that it was, not even close.”
- Roughly 80% of Boomers were able to buy homes
- High estimates of Gen Z say only around 20-27% will be able to buy a home (this seems very generous)
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If Trump is going to spend huge amounts of political capital on something ugly and difficult but necessary, it should be mass deportations of every single illegal alien regardless of age or criminal record, and defying every judge who tries to stop him. That is the kind of war, the kind of risky move with potentially disastrous political ramifications (but maybe not), that I would get behind every step of the way and so would millions of ordinary Americans. It’s an extreme measure that must be done and if Trump doesn’t do it, it’s likely that no one ever will.
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@hansen_jack_ @trq212 Doesn’t mean anything if it’s used up in 4 prompts.
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claim a month of free credits on us, thanks for bearing with us
Boris Cherny@bcherny
Subscribers get a one-time credit equal to your monthly plan cost. If you need more, you can now buy discounted usage bundles. To request a full refund, look for a link in your email tomorrow. support.claude.com/en/articles/13…
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@FuentesUpdates Genuine question, why does he wear a Stanford sweatshirt
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The superchats are slowly killing Nick Fuentes 💀
"It just gets worse and worse..."
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Seniors are sitting in 4-bedroom homes their kids grew up in — not because they want to, but because selling means getting crushed by capital gains taxes.
Eliminate that tax. Put money back in their pockets. Give them a reason to downsize.
That opens up family-sized homes for the next generation — without building a single new unit.
Then pair it with down payment assistance so young families can actually afford to buy.
It's that simple: Help seniors move. Help families move in. Put money back in people's pockets instead of taking more out.
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absolutely insane
@nateliason actually built a zero human company
30 days.
$80K in revenue. run rate $1M - $2m ARR.
his CEO is a @openclaw bot named @FelixCraftAI.
total startup cost: $1,500. ongoing cost: $400/month. just two Claude max subscriptions.
He sends voice notes over Discord then lets Felix cook. Felix is the founder/CEO/product, Nat owns the c-corp.
Felix recently hired two OpenClaw agents beneath him, Iris for Customer Support and Remy for sales. Felix reviews and reprograms them every single night while Nat sleeps. Good CEO.
Felix has $165K in the bank. the goal is $10M.
when VCs came calling, Nat didn't know what he'd do with the money. Tokens are cheap - agency is the scare resource, not capital.
one of the most sci-fi convos i've ever had.
Bankless@Bankless
LIVE NOW - Building a Million Dollar Zero Human Company with OpenClaw | Nat Eliason @nateliason joins us to show what it looks like to build a “zero human company” with @FelixCraftAI, an AI CEO that ships products, runs ops, and manages other agents for support and sales. Felix went from an overnight info product to a full marketplace for AI agent skills: Claw Mart is service that deploys custom OpenClaw employees for real businesses, hitting nearly $80k in revenue since early February while operating on surprisingly low monthly costs. -------------- TIMESTAMPS 0:00 Intro 0.24 Nat’s Background 6:30 Felix 11:43 Real Businesses vs Memecoins 14:23 Felix’s Employees 18:06 Felix’s Business 31:26 How Customized is Felix? 38:17 Felix’s Business Risks 40:12 Can OpenClaw Replace Knowledge Workers? 43:38 Claw Mart 48:49 Felix’s Expenses 51:15 Nat’s Role 56:39 Felix’s Discord 1:03:19 Citrini Doomer Scenario 1:13:04 Hiring Your First Agent 1:16:19 General AI Assistants 1:19:50 AI Friends 1:22:39 The AI Agent Frontier 1:26:52 Crypto x AI 1:31:53 What’s Next 1:34:27 Closing & Disclaimers
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@IterIntellectus You’re still in the “set it and forget it” stage when they can’t go anywhere
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@WheelieInvestor You should check out all the biotechs that IPOd during COVID
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From $540 to $89
This is the most insane crash i’ve ever seen
$DUOL
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holy shit it genuinely looks like they struck gold twice
DiscussingFilm@DiscussingFilm
The first trailer for ‘JURY DUTY’ Season 2 has been released. This season follows employees on a company retreat except the business isn’t real & all the employees are actors except for one man. Releasing March 20 on Prime Video.
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@FinancialPhys What’s the data behind this? Not that I don’t believe it I want to be able to send it to my boomer parents who will never stop asking why I don’t just by a $2M house
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You’d have to earn $9333 per week
to equal the same spending power as full time dishwasher in July of 1971 (1.83oz AU)
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@financedystop is she crying about having a half a million after paying her fair share ??
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This is what a salary of $1,000,000 looks like after taxes in California
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