Linghua Wang, MD, PhD

@Cancer_Cell review out—led by @liuyunho @Yibo_Dai #SpatialOmics advances (tech, analytics, applications). Single cells → niches/communities → tumor ecosystems + a roadmap to translation. Grateful to editors, reviewers, support from @MDAndersonNews @break_cancer @NIH @theNCI

@aadel_chaudhuri @yuanjamesrao @MayoRadOnc @AaronNewmanLab @StanfordCancer @NIH Incredible🌟huge congratulations, Aadel and Aaron! 🎉🎊👏

Humbled to share that our latest R01 from @MayoRadOnc, in close collaboration with @AaronNewmanLab @StanfordCancer, was scored at the 1st percentile by @NIH study section. Grateful to an outstanding team and collaborators who made this possible, and excited for the work ahead!

Looking forward to a fantastic meeting led by an outstanding scientific committee @Aiims1742, Giulia Biffi and Dieter Saur and a stellar lineup of speakers. Incredibly honored to speak. Don’t miss this exciting opportunity. Sunday, Mar 15, is the last day to submit your abstract!

2. Although most work and attention has been on engineering T cells, macrophages are the most abundant immune cells in tumors and many strategies are now emerging to target these cells Reviewed here sciencedirect.com/science/articl…

Online Now: Macrophages: Targets for next-generation cancer immunotherapy dlvr.it/TRB5tg

#AGBTGM26 just kicked off! 🚀 So excited to be here with an amazing community pushing the frontiers of genome biology, spatial omics, and AI-driven discovery. So much to learn, and I’ll be giving a talk tomorrow evening😁Looking forward to great discussions and exchanging ideas✨

Grateful to @GarryPNolan @NinaBhardwaj and Toni for the opportunity to speak at #AACRIO26 and thanks to the audience for the fantastic questions. This has been an absolutely incredible meeting, and I’ve learned so much🤩. Wonderful to reconnect with friends and colleagues.

New Online! Subcellular localization as a driver of protein function dlvr.it/TR2D3c

An imaging-free spatial transcriptomics method facilitates high-throughput barcode array generation up to centimeter scale go.nature.com/3QYfSDd rdcu.be/e4Db0

🌟Out today in Nature Cancer, two automated tools to analyze prognostic spatial features of TNBC @MikeAngeloLab @JoleneRanek @NoahGreenwald 🔗nature.com/articles/s4301… 🔗nature.com/articles/s4301… And read the associated News & Views from @hartjackson nature.com/articles/s4301…

Online Now: Knowledge-enhanced pretraining for vision-language pathology foundation model on cancer diagnosis dlvr.it/TR3bcr

Thrilled to share our first iteration of IL-12–armored CAR T cells targeting tumor associated macrophages (TAM) to treat metastatic cancer. Led by the fantastic @jaimemateustique as a collaboration between @brown_lab1 and my lab @sinaiimmunology. authors.elsevier.com/a/1mUUD5TA51lD… (1/4)

Now online in @CD_AACR: Single-Cell Spatial Atlas of High-Grade Serous Ovarian Cancer Uncovers MHC Class II as a Key Predictor of Spatial Tumor Ecosystems & Clinical Outcomes - by @FrandoPV, Hugo Horlings, @afarkkila, et al. doi.org/10.1158/2159-8… @SystemTumor @iCAN_Finland

In case you missed it, check out our study showing the crucial and contextual role of inflammation via IL1b/IL1R1 signaling in progression of lung premalignant lesions and alveolar progenitors

Huge congrats, Anirban @Aiims1742 🎉! So well deserved — a visionary leader! 🌟Excited for you and @Perlmutter_CC. 🎉

An update to the Hallmarks of Cancer framework for understanding (and researching) what causes human cancers. spkl.io/6010Aqwbi Douglas Hanahan @CellCellPress

Metastasis is the infiltrator. It is the means by which cancers start in one part of the body and suddenly end up elsewhere-- spreading destruction, and by simple statistics, enabling the genomic diversity that promotes drug resistance for the cancer. How does this happen? Well, it appears part of the problem starts, at least for head and neck cancer, with tumor cells initiating organizational changes in the lymph node wherein cancer has established itself, and initiated pro-cancer environments both locally and at a distance. Myeloid cells and cancer-associated fibroblasts are somehow instructed by distant cancer to "open the door" for seeding of the originating cancer-- which then further enables spread to nearby locales. In layman's terms... they prepare the ground elsewhere for their own defense. Cancer uses your own immune system against you. Congratulations to MH in my lab and to the many others from the collaborative University of Heidelberg & Mainz German Cancer Network who worked this out. The work offers new avenues of attack against such cancers by targeting cell-cell interactions beyond the current therapeutic framework. It also means we might be able to see, in non-metastatic lymph nodes, niche rearrangements that indicate cancer is nearby. It is now an open-source article online and in press at Cancer Cell. sciencedirect.com/science/articl…

AlphaGenome is out in @nature today along with model weights! 🧬 📄 Paper: nature.com/articles/s4158… 💻 Weights: github.com/google-deepmin… Getting here wasn’t a straight path. We sat down @googledeepmind to discuss the story behind the model, paper & API: youtu.be/V8lhUqKqzUc

Critical role for a high-plasticity cell state in lung cancer @Nature @TuomasTammela @MSKCancerCenter nature.com/articles/s4158…

CRISPRi/a-based Perturb-seq screen in patient-derived fibroblasts identifies an IFN-I-responsive program that antagonizes the TGF-β-dependent myofibroblast program via ADAM12 @Cancer_Cell cell.com/cancer-cell/fu… 🇨🇳

SpatialZ generates virtual single-cell transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues. @Forestlin030 @Zachary_Zhikang @Y4nCu1 @qizou97 @CS_HCY nature.com/articles/s4159…