E.S.

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E.S.

E.S.

@iseethepacific

I kept learning more and more about less and less until I knew absolutely everything about nothing at all. And for that, they gave me a PhD.

Southern California Katılım Aralık 2013
1.5K Takip Edilen191 Takipçiler
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E.S.
E.S.@iseethepacific·
Taught my kid basic principles of genetic engineering. Still trying to teach her how to smile for the camera. #futurenerd
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Mgoes (bio/acc 🤖💉)
Mgoes (bio/acc 🤖💉)@m_goes_distance·
I met a biotech founder who was raising a Series A he said he was building Palantir for biotech "what does that mean exactly?" "we aggregate clinical trial data and surface insights for pharma" "so a dashboard?" "a very sophisticated dashboard" "with AI" "obviously" he raised $12M I still don't know what bro is building.
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E.S.
E.S.@iseethepacific·
@nikillinit my understanding is VSP is both my insurance… and the owner of the 👁️ shops (visionworks, etc) I take my insurance too and get a “discount” at. It seems like I’m basically buying a vision-subscription, branded as “insurance”.
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Nikhil Krishnan
Nikhil Krishnan@nikillinit·
Dental and vision insurance are pretty obviously bad deals - even the employers know when I ask brokers, the consensus answer seems to be "it's cheap for the employer to offer and having it gives the perception of good benefits to employees"
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E.S.
E.S.@iseethepacific·
@DallasAptGP @_contraryan can i get access to this map? really interested in the locations of WA and OR states.
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Barrett Linburg
Barrett Linburg@DallasAptGP·
@_contraryan OZ requires the property to be used in a business, like a rental. A home you live in is personal use, which doesn't qualify. Build it and rent it out and you're back in the game.
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Barrett Linburg
Barrett Linburg@DallasAptGP·
You can build or renovate real estate in any of these shaded areas and never pay tax on the appreciation Also never recapture the depreciation losses you take during the hold period Amazed that I am the only one on Twitter yelling about this
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E.S. retweetledi
Avi Roy
Avi Roy@agingroy·
A weekly jab in the belly is generating more revenue than the entire AI industry. Ozempic + Mounjaro: $71B in 2025. OpenAI + Anthropic: $29B. And they've barely started. ~2% of the 800 million eligible patients can currently access them. h/t @DrSamuelBHume
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Alex Cohen
Alex Cohen@anothercohen·
I bought a smart toilet device that tracks your gut health and I’ve never been so excited to take shits
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Patrick McKenzie
Patrick McKenzie@patio11·
@ankurnagpal Yes, various private banks run funds which do this. Contribute stock to fund, receive shares in fashion everyone hopes will be taxless, fund picks up grab bag of tech stocks and rounds out with easily liquid ones. (Heard about it from Matt Levine IIRC; have not ever used one.)
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Ankur Nagpal
Ankur Nagpal@ankurnagpal·
Are there any financial products to diversify large single company exposure in the private markets? i.e. if I own $10M of SpaceX, and I want to exchange part of it for a diversified basket of other high quality startups Could be a useful product for lots of people
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E.S.@iseethepacific·
@patio11 @ankurnagpal yes this. And then so same banks will give you a line of credit, collateralized by this now less-risk diversified basket of equity made by you and others like you. It’s a nice idea actually.
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Camus
Camus@newstart_2024·
Richard Feynman’s savage takedown of pseudo-science still burns in 2026: “Social science is an example of a science which is not a science. They follow the forms… but they don’t get any laws. They haven’t found out anything.” He goes harder: Experts who “sit at a typewriter and make up” claims — “organic food is better,” “this diet cures everything” — as if it’s settled science, when no rigorous experiments or checks have been done. Feynman: “I know what it means to really know something. How careful you have to be. How easy it is to fool yourself. I see how they get their information… and I can’t believe that they know.” The Nobel physicist calls it straight: most of what passes for “expert” opinion is noise dressed up as knowledge. In an age drowning in TikTok “science,” influencers, and clickbait studies — Feynman’s 1:52 rant feels more relevant than ever. Who’s the biggest pseudo-expert that grinds your gears right now? Clip is timeless fire — watch it and feel the clarity.
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E.S.
E.S.@iseethepacific·
@KYRRadio @bhargreaves stay. Help fund/advocate the challenge to this nonsense. State Constitution and case law will result in a challenge. Income Tax is a failed argument, they might try to call this an excise tax on the privilege of income… but that’s transparent nonsense.
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Zach Abraham
Zach Abraham@KYRRadio·
@bhargreaves You're dead on the money. We are leaving WA state. I cannot tell you how many are doing the same or have already left. It will be a hellscape in years. Pushes our overall tax rate north of CA and NY!
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NBC News
NBC News@NBCNews·
ChatGPT Health — OpenAI’s new health-focused chatbot — frequently underestimated the severity of medical emergencies, according to a study published in the journal Nature Medicine. nbcnews.com/health/health-…
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E.S.
E.S.@iseethepacific·
@EricTopol could one (do they?) weight the HR effect onto the prevalence of each and estimate the burden per 100,000? i.e. a greater absolute effect from CRC vs pancreatic.
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BuccoCapital Bloke
BuccoCapital Bloke@buccocapital·
@AJButton2 Will get wrapped in a UI. And advisors will use it to scale. Fee compression. Low end eaten
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BuccoCapital Bloke
BuccoCapital Bloke@buccocapital·
Unless you have $5M+, AI is already good enough to be your financial advisor. Even then it’s probably good enough Try it. Share net worth, where/how you’ve allocated assets, what your goals are. Ask it to analyze and identify opportunities for improvement. Stress test different scenarios It gets basically everything right. Which tax advantaged accounts to use. Whether and which trusts to set up based on federal and state variables. Yup, estate planning advice too Really remarkable. And speaks to the fact that even if the models don’t improve, what we have today is going to totally transform white collar work
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E.S.
E.S.@iseethepacific·
@themoviedadsc but the last 15 of those 20 have been the wildest anomaly of the broadest and longest bill run in history. Random unmanaged of course can win in such a thing. What does it look like in a truly typical 20yr window?
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Sean Cranston
Sean Cranston@themoviedadsc·
Extra context on "beating the S&P 500 over the long-term consistently is very difficult." 91% of *professional* fund managers failed to beat the S&P 500 over the last 20 years. Stock investing is a game you ironically win BIG by not trying too hard (just use index funds/ETFs).
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The Money Cruncher, CPA@money_cruncher

Beating the S&P 500 is not impossible. Beating the S&P 500 over the long term consistently is very difficult. Buying the market (e.g $VTI or $VOO) is one of the best ways to invest for the 99% of people. Simple and effective.

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E.S.@iseethepacific·
@ErikKaiser @trevizo_gabe Rocking chair test: Imagine yourself as an old man, sitting in a rocking chair on the front porch of your house and thinking about this moment you are in. If there’s any chance that in that rocking chair, you’ll wish you had made the hard choice… then make the hard choice today.
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Erik Kaiser
Erik Kaiser@ErikKaiser·
@trevizo_gabe The question is not what of it doesn’t work. It’s what happens if you don’t try.
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Gabe Trevizo
Gabe Trevizo@trevizo_gabe·
My son and I were talking about an idea he had. He asked "What if it doesn’t work?” That question never goes away. You just get older when you ask it. The answer stays the same: Try anyway.
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E.S.
E.S.@iseethepacific·
@NWischoff possibly Debut Bio in San Diego.
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Nichole Wischoff
Nichole Wischoff@NWischoff·
Very interested in peptides/US manufacturing of them. Who is working on this?
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E.S.@iseethepacific·
@Ronalfa evidence: Calico the king of software can’t even find much luck in lifesci, nearly 15yrs of effort.
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Mark
Mark@Marksg1lz·
Can COINBASE just settle WLUNA? You guys were a custodian, and middle man for this criminal, froze our assets “”temporarily”” , kept us out the loop, pocketed airdrops, gave inaccurate prices, tethered it to the wrong coin, didn’t honor the smart contract. There’s much more too
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Ran.Withit
Ran.Withit@wavedawgyy·
Absolutely! Cannot wait out the clock when you knowingly committed fraud against investors in violating an immutable contract. Compounded by the fact holders were proactively trying to recover their asset. Worst defense strategy ever. C’mon Brian- make it right! @coinbase @brian_armstrong $Wluna $Luna
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Dos Commas ,, ♦️♦️♦️♦️
Can't believe we thought @coinbase was working behind the scenes to help their customers in the Wrapped LUNA Token situation. Only to find out they were perfectly happy to let us believe this and then have the audacity to mention the statute of limitations. $wLUNA = $wLUNA
GIF
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♦️♦️♦️@tdub285·
Hey Coinbase when are you gonna pay us $wluna
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🏴‍☠️@calvinfroedge·
An hour off the coast of LA by boat with no gangs and no pollution. How is Catalina Island so cheap? Are we in a recession?
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