Aeon

@IterIntellectus AI will see to it that we get dumber because we farm out intelligence work to our favorite LLM.

this is why AI and humanoid robots are the only way for humanity to survive we are getting much dumber and it’s never going to get better

@Jainadave_ Sure. Start with 5 minutes per day, if that, and work your way up from there, while listening to your body.

Is running every day healthy?

@drmikehart Metamucil anyone?

Every 10 grams of fiber is associated with an 11% decrease in all-cause mortality. Those in the highest group had a 23% decrease in all-cause mortality compared to those in the lowest group.

@AlpacaAurelius Can you give some examples?

most health trends are just cortisolmaxxxxing and sabotaging your health cold plunging, keto, fasting, blood filtration, injecting yourself, HIIT.... you can't heal when your body is in fight or flight... most people need to be parasympathetic maxxxing instead

@Save_A_Man Can you please check your crystal ball and let me know if pharmacists are safe? Please and thank you.

Jobs that AI will eliminate in 5-10 years: Taxis Actors Writers Doctors Soldiers Lawyers Cashiers Teachers Surgeons Sales reps Truck drivers Accountants Food delivery Customer service Construction workers Are you paying attention yet?

@drdenwalker Gotta get walnuts into the rotation.

Walnuts are often regarded as the healthiest nut. They boast some of the highest levels of antioxidants and omega-3 fatty acids. Consuming 3 servings of nuts each week can lead to a 67% reduction in overall mortality, a 40% decrease in cancer risk, and a 60% lower chance of heart attacks. pmc.ncbi.nlm.nih.gov/articles/PMC39…

@SBakerMD That’s a crazy statistic. I blame cheap dopamine

70% of Americans do no strength training ! Strength training helps your brain to function better!

@dr_ericberg Morning walk once it becomes a habit.

What is one healthy routine that feels the easiest for you to maintain?

@bryan_johnson I’m sorry for your loss Bryan.

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

@louisanicola_ Nothing like a good laugh. Highly underrated if you ask me.

@TimeproofRx Definitely, laughter boosts endorphins and lowers stress even more, so it’s like upgrading that daily reset.

A recent study found something important for brain health. Just one real conversation a day can boost your mood and lower stress. It doesn’t have to be deep. Talking, laughing, or simply listening all help your brain feel better. Connection is not extra. It is part of staying healthy. Social connection is essential for mental and physical health. Source: Hall, J. A., Holmstrom, A. J., Pennington, N., Perrault, E. K., & Totzkay, D. (2025). Quality Conversation Can Increase Daily Well-Being. Communication Research, 52(3), 291-315.

@yoursimmo11 Nice take. I think it’s also about tackling your biggest problem first which is deferent for everyone.

Every man I work with over 40 is doing more on his health than 99% of the population. Training 5-6 days a week, tracking everything, taking 20+ supplements, and seeing multiple doctors. But he’s still exhausted, still gaining weight and still can’t sleep. The problem was never effort, it was interference. Most of my work involves removing things, not adding them.

@MasalaFry69 @davidasinclair How does that help fasting blood glucose though?

@TimeproofRx @davidasinclair The best way is to cut the carbs

High fasting glucose predicts cardiovascular disease. Stabilize blood sugar.

@winston_zin Love this. Sitting is torture if you ask me.

Sitting for 8+ hours a day increases all-cause mortality risk by 60%... Even if you exercise. It compresses your spine, spikes blood sugar, and weakens your glutes. 7 simple desk habits to counteract the damage in under 2 minutes: 1. Seated calf raises

@smithhmackenzie 100%. Popularity of alcohol is a big conspiracy, if you ask me, meant to benefit ‘Big Alcohol’.

I get asked a lot why I don’t drink It's because I don't see the point It's not enjoyable, it's empty calories, and I end up feeling like shit My sleep, training, and productivity will be impacted There's just no value to me personally Anyone else relate to this?

@CoachDanGo @rand_longevity Great. I was thinking 15. I like 5 for minimum effective dose. 20 is painful! 😣

@TimeproofRx @rand_longevity At the very least 5. Sweet spot is 20 minutes.

morning routine checklist: - coffee - creatine - 10 mins of sunlight - 16oz of water - long walk what would you add?

@DrSuneelDhand 💯 I’d prefer that my life not be in the hands of a disgruntled cashier at my local corporate pharmacy chain.

I’m a physician, and I would literally do anything to avoid being on a prescription drug. My nightmare is to have to show up at the pharmacy every month and pick up drugs. Absolute last resort only. Will exhaust every other possibility before that happens.

@ted_ryce We are a nation of people looking for a quick fix.

The real reason TRT is so popular over 40: It lets you live like crap without feeling like crap. Too fat. Eat poorly. Sleep poorly. Train too hard. Testosterone still looks “great.” Because it’s artificial. No lifestyle change required.

@joeyyochheim I think the mental component is also under appreciated. Even being slightly overweight can impact your vitality.

Being overweight or obese is one of the worst things you can do to your health. It increases your risk for: • Type 2 diabetes • Certain cancers • Joint problems • Heart disease • Sleep apnea • Stroke Generally, only smoking and alcoholism have a more significant negative impact on long-term health outcomes. This isn't moral judgment. It's a medical reality.

@ChamberofFit Interesting. Appreciate the input.

@TimeproofRx No I wouldn’t unless it’s something you enjoy and that makes you feel good

Stop overcomplicating nutrition. If 90-95% of your diet is: - potatoes - eggs - egg whites - honey or maple syrup - salmon - greek yogurt - lean steak - lean ground beef - veggies - oysters - shrimp - rice - berries - variety of other fruit You’re basically guaranteed to be a healthy human while thoroughly enjoying what you eat.

@JohnnyAGI @Nithya_Shrii Agree 100%. I think Elon would agree also.

@Nithya_Shrii Almost all of these jobs are easily replaceable once consumer robotics come out, which is within 5-7 years. Our current economical model isn't built to sustain AI's ability to replace human skill. Big changes coming soon

10 jobs that are 100% safe from AI: 1. Dentist 2. Construction worker 3. Plumbing 4. Farming 5. Gardening 6. Carpentry 7. Cooking 8. Gardening 9. Welder 10. Electrician Did I miss any?!